10,249 research outputs found

    RSRM-11 (36OW011) ballistics mass properties (STS-35)

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    The propulsion performance and reconstructed mass properties data from Thiolol's RSRM-11 motors which were assigned to the STS-35 launch are contained. The Thiokol manufacturing designations for the motors were 360W011A/360W011B, which are referred to as RSRM-11A and RSRM-B, respectively. The launch of STS-35 occurred on 2 December 1990 at the Eastern Test Range (ETR). The data contained herein was input to the STS-35 Flight Evaluation Report. The SRM propellant, TP-H1148, is a composite type solid propellants, formulated of polybutediene acrylic acid, acryonitrile terpolymer binder, epoxy curing agent, ammonium perchlorate oxidizer, and aluminum powder fuel. A small amount of burning rate catalyst (iron oxide) was added to achieve the desired propellant burn rate. The propellant evaluation and raw material information for the RSRM-11 are included. The ballistic performance presented was based on the Operational Flight Instrumentation (OFI) 12.5 sample per second pressure data for the steady state and tail off portion of the pressure trace. Recent studies have shown that the transducers are affected by the measuring system at KSC and temperature gradients created by the igniter heaters. Therefore, an adjustment to the data from each transducer is made to make the initial reading match the atmospheric pressure at the time of launch

    Morphine activates neuroinflammation in a manner parallel to endotoxin

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    Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors. Herein, we provide direct evidence that morphine creates neuroinflammation via the activation of an innate immune receptor and not via classic opioid receptors. We demonstrate that morphine binds to an accessory protein of Toll-like receptor 4 (TLR4), myeloid differentiation protein 2 (MD-2), thereby inducing TLR4 oligomerization and triggering proinflammation. Small-molecule inhibitors, RNA interference, and genetic knockout validate the TLR4/MD-2 complex as a feasible target for beneficially modifying morphine actions. Disrupting TLR4/MD-2 protein–protein association potentiated morphine analgesia in vivo and abolished morphine-induced proinflammation in vitro, the latter demonstrating that morphine-induced proinflammation only depends on TLR4, despite the presence of opioid receptors. These results provide an exciting, nonconventional avenue to improving the clinical efficacy of opioids.Xiaohui Wang, Lisa C. Loram, Khara Ramos, Armando J. de Jesus, Jacob Thomas, Kui Cheng, Anireddy Reddy, Andrew A. Somogyi, Mark R. Hutchinson, Linda R. Watkins and Hang Yi

    Electron Temperature of Ultracold Plasmas

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    We study the evolution of ultracold plasmas by measuring the electron temperature. Shortly after plasma formation, competition between heating and cooling mechanisms drives the electron temperature to a value within a narrow range regardless of the initial energy imparted to the electrons. In agreement with theory predictions, plasmas exhibit values of the Coulomb coupling parameter Γ\Gamma less than 1.Comment: 4 pages, plus four figure

    Territorial Issues, Audience Costs, and the Democratic Peace: The Importance of Issue Salience

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    Democratic leaders are more prone to domestic sanction following defeats, and these audience costs allow democracies to signal their intentions during public disputes. Empirical tests strongly support this relationship; however, recent criticisms have questioned whether the causal mechanisms of audience costs are responsible for these findings. We provide a unified rationale for why both arguments are correct: democracies rarely contend over territorial issues, a consistently salient and contentious issue. Without these issues, leaders are unable to generate audience costs but are able to choose easy conflicts. Our reexaminations of threat-based and reciprocation-based studies support this argument. We also present tests of within-dispute behavior using MID incident data, which confirms that the salience of territory matters more than regime type when predicting militarized behavior. Any regime differences suggest a disadvantage for democratic challengers over territorial issues, and any peace between democracies results from the dearth of salient issues involving these regimes

    Human Factors Engineering at Marshall Space Flight Center

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    The mission of NASA Marshall Space Flight Center (MSFC) is to develop, implement, and maintain systems for space transportation and microgravity research. Factors impacting the MSFC position as a leader in advancing science and technology include: (1) heightened emphasis on safety; (2) increased interest in effective resource utilization; and (3) growing importance of employing systems and procedures that pragmatically support mission science. In light of these factors, MSFC is integrating human factors engineering (HFE) into the systems engineering process. This paper describes the HFE program, applications of HFE in MSFC projects, and the future of HFE at MSFC

    A statistical approach for predicting grassland degradation in disturbance-driven landscapes

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    Maintaining a land base that supports safe and realistic training operations is a significant challenge for military land managers which can be informed by frequent monitoring of land condition in relation to management practices. This study explores the relationship between fire and trends in tallgrass prairie vegetation at military and non -military sites in the Kansas Flint Hills. The response variable was the longterm linear trend (2001-2010) of surface greenness measured by MODIS NDVI using BFAST time series trend analysis. Explanatory variables included fire regime (frequency and seasonality) and spatial strata based on existing management unit boundaries. Several non-spatial generalized linear models (GLM) were computed to explain trends by fire regime and/or stratification. Spatialized versions of the GLMs were also constructed. For non-spatial models at the military site, fire regime explained little (4%) of the observed surface greenness trend compared to strata alone (7% - 26%). The non-spatial and spatial models for the non -military site performed better for each explanatory variable and combination tested with fire regime. Existing stratifications contained much of the spatial structure in model residuals. Fire had only a marginal effect on surface greenness trends at the military site despite the use of burning as a grassland management tool. Interestingly, fire explained more of the trend at the nonmilitary site and models including strata improved explanatory power. Analysis of spatial model predictors based on management unit stratification suggested ways to reduce the number of strata while achieving similar performance and may benefit managers of other public areas lacking sound data regarding land usage

    POLICY IMPLICATIONS OF RESTRICTED ACCESS STRATEGIES FOR MULTISPECIES FISHERIES

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    The commercial fishery that primarily targets king mackerel, stone crab, snappers, groupers and spiny lobster in Monroe and Collier counties is one of the most important commercial fisheries in Florida. These species currently face problems of overfishing and/or over capitalization. A dual-based restricted profit function is used to estimate the economic and technical interactions that exist in this multi-species fishery, primarily using own-price and cross-price elasticities of supply. It is found that the production technology does not exhibit input-output separability and nonjointness-in-inputs over all species groups. This result suggests that these key species may be more efficiently managed as a group, rather than with the use of existing single species regulations. Spiny lobster and stone crab, the dominant value species in the fishery, are shown to have very elastic substitution relationships with king mackerel.Resource /Energy Economics and Policy,

    A qualitative study of men’s recollections of growing up with father absence: childhood father figures and family resilience

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    © 2017 Informa UK Limited, trading as Taylor & Francis Group. Background: Families come in many forms and single parent women headed households are common with nurses being well positioned to provide support for these women and their children. For children growing up in lone parent households, the nature of family relationships and the availability of a social support network are important factors in reducing developmental risks. Aim: The aim of this study was to explore adult men’s recollections of growing up in a father-absent home. Design: This study utilised a qualitative methodology. Methods: Semi-structured interviews were conducted with 21 adult men who grew up in a father-absent home due to family discord. Interview transcripts were thematically analysed using an inductive approach. Findings: Analysis of the interview transcripts revealed two themes relating to childhood father figures and family relational networks. For some men, ambivalent, violent or unavailable father figures stepped into the void created by the absent father. Others experienced positive father figures or multigenerational relationships, which provided positive relational supports and attachments. Conclusion: The findings illuminate the dynamics of family resilience and provide important insights for nurses and other family healthcare workers
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