Rheology and porosity effect on the proliferation of preosteoblast on zirconia ceramics

It has been studied ZrO2(MexOy) based porous ceramics, obtained from the powders consisting of hollow spherical particles. It was shown that the structure is represented as a cellular carcass with a bimodal porosity, formed of a large pore close to a spherical shape and the pores that were not filled with the powder particles during the compaction. For such ceramics the increase of pore volume is accompanied by an increase in strain in an elastic area. It was also shown that the porous ZrO2 ceramics had no acute or chronic cytotoxicity. At the same time, ceramics possess the osteoconductive properties: adhesion support, spreading, proliferation and osteogenic differentiation of MSCs

Certain features of using modified collagen-containing raw materials with prolonged shelf life in food technology

In the current circumstances, trends in nutrition of a person striving to lead a healthy life-style require intake of meat products with the reduced energy value, minimal amounts of fat, increased protein mass fraction, presence of substances improving homeostasis of the body. The synergism of the modern nutrition science and meat industry enables creating food products that satisfy consumers’ demand. Today, in the Russian Federation, a theoretical and practical base of the technology development has been collected to the full extent in the field of rational processing of secondary raw materials in the food industry, optimal use of animal secondary raw materials, study of the protein ingredients of animal and plant origin and their deep scientifically substantiated processing, improvement of technological processes and equipment, and correspondently, product range extension. The paper broadens the information about the modified collagen-containing raw materials (cattle rumen), examines physico-chemical characteristics of the collagen-containing raw material and its changes in the process of freeze-drying with a special attention paid to the study of changes in the histological structure. The presence of the relatively uniform fibrillar structure was determined, which facilitated discovering the functional potential of proteinoids that form the fibrillar matrix in the composition of products from different groups. Analysis of IR-spectra revealed several significant absorption bands linked with the state of peptide bonds. The character of bands is linked with the complex of valence and deformation vibrations of the N- and С- types. It is believed that IR-spectra reflect conformations in the protein secondary structure, which suggests preserving properties of the tropocollagen particle or collagen molecule. Freeze-dried modified collagen-containing cattle rumen was tested by the example of jellies. The obtained databank broadens information about physico-chemical properties of modified collagen-containing raw materials (cattle rumen).In the current circumstances, trends in nutrition of a person striving to lead a healthy life-style require intake of meat products with the reduced energy value, minimal amounts of fat, increased protein mass fraction, presence of substances improving homeostasis of the body. The synergism of the modern nutrition science and meat industry enables creating food products that satisfy consumers’ demand. Today, in the Russian Federation, a theoretical and practical base of the technology development has been collected to the full extent in the field of rational processing of secondary raw materials in the food industry, optimal use of animal secondary raw materials, study of the protein ingredients of animal and plant origin and their deep scientifically substantiated processing, improvement of technological processes and equipment, and correspondently, product range extension. The paper broadens the information about the modified collagen-containing raw materials (cattle rumen), examines physico-chemical characteristics of the collagen-containing raw material and its changes in the process of freeze-drying with a special attention paid to the study of changes in the histological structure. The presence of the relatively uniform fibrillar structure was determined, which facilitated discovering the functional potential of proteinoids that form the fibrillar matrix in the composition of products from different groups. Analysis of IR-spectra revealed several significant absorption bands linked with the state of peptide bonds. The character of bands is linked with the complex of valence and deformation vibrations of the N- and С- types. It is believed that IR-spectra reflect conformations in the protein secondary structure, which suggests preserving properties of the tropocollagen particle or collagen molecule. Freeze-dried modified collagen-containing cattle rumen was tested by the example of jellies. The obtained databank broadens information about physico-chemical properties of modified collagen-containing raw materials (cattle rumen)

Myocardial remodeling and fibroblast growth factor in patients with resistant hypertension

Aim. To study the prevalence and severity of left ventricular hypertrophy (LVH), its relationship with fibroblast growth factor (FGF23) in patients with resistant hypertension (RH) depending on the effectiveness of multiagent antihypertensive therapy.Material and methods. The study included 92 patients diagnosed with RH. All patients underwent 24-hour ambulatory blood pressure monitoring (ABPM), echocardiography, general laboratory tests, and the serum FGF23 level was determined.Results. According to ABPM results, patients were divided into following groups: 1st — controlled RH (n=44) and 2nd — uncontrolled (n=48) RH. The groups were comparable in sex, age, main clinical and anthropometric parameters. In group 2, the main parameters of ABPM were higher. There were no differences in general laboratory tests, In the group of uncontrolled RH, the level of FGF23 was higher — 11,7 [8,5; 15,4] pmol/ml vs 9,2 [7,1; 11,6] pmol/ml in the 1st group (p=0,0036). According to echocardiography, a comparable violation of left ventricular (LV) diastolic function, an increase in left atrial size, LV mass (LVM) and LVM index were found. In patients of the 2nd group, large values of interventricular septal thickness were revealed — 1,3 [1,2; 1,4] cm vs 1,2 [1,1; 1,3] cm in the 1st group (p=0, 0043) and relative LV wall thickness (LVWT) — 0,50 [0,48; 0,53] vs, 0,45 [0,43; 0,50] in the 1st group (p<0,0001). In the 1st and 2nd groups, concentric LVH was more common (18 (41%) patients in the 1st and 26 (54,1%) in the 2nd (p=0,044) groups) than eccentric LVH (15 (34,1%) and 13 (27,1%) patients in the 1st and 2nd groups, respectively). Correlation analysis revealed a positive relationship between pulse pressure and HTN duration (r=48, p=0,02) and FGF23 level (r=0,62, p=0,004). The LVM index was positively associated with the diastolic pressure-time index (BP) (r=51, p=0,02). A positive correlation was found between relative LVWT and pulse pressure (r=0,64, p=0,02) and a negative relationship with the duration of regular antihypertensive therapy (r=47, p=0,04), A strong relationship was found between LVEF and FGF23 levels (r=0,75, p=0,005).Conclusion. For patients with uncontrolled resistant hypertension, an increase in pulse pressure and myocardial remodeling in the form of concentric hypertrophy are more characteristic. FGF23 is significantly higher in uncontrolled RH and is positively associated with pulse pressure and relative LVWT

Systematic study of the low-lying electric dipole strength in Sn isotopes and its astrophysical implications

The $\gamma$-ray strength functions (GSF) and nuclear level densities (NLD) below the neutron threshold have been extracted for $^{111-113,116-122,124}$Sn from particle-$\gamma$ coincidence data with the Oslo method. The evolution of bulk properties of the low-lying electric dipole response has been investigated on the basis of the Oslo GSF data and results of a recent systematic study of electric and magnetic dipole strengths in even-even Sn isotopes with relativistic Coulomb excitation. The obtained GSFs reveal a resonance-like peak on top of the tail of the isovector giant dipole resonance, centered at $\approx$8 MeV and exhausting $\approx$2\% of the classical Thomas-Reiche-Kuhn (TRK) sum. In contrast to predictions of the relativistic quasiparticle random-phase and time-blocking approximation calculations (RQRPA and RQTBA), no monotonous increase in the total low-lying $E1$ strength was observed in the experimental data from $^{111}$Sn to $^{124}$Sn, demonstrating rather similar strength distributions in these nuclei. The Oslo GSFs and NLDs were further used as inputs to constrain the cross sections and Maxwellian-averaged cross sections of $(n,\gamma)$ reactions in the Sn isotopic chain using TALYS. The obtained results agree well with other available experimental data and the recommended values from the JINA REACLIB, BRUSLIB, and KADoNiS libraries. Despite relatively small exhausted fractions of the TRK sum rule, the low-lying electric dipole strength makes a noticeable impact on the radiative neutron-capture cross sections in stable Sn isotopes. Moreover, the experimental Oslo inputs for the $^{121,123}$Sn$(n,\gamma)$$^{122,124}$Sn reactions were found to affect the production of Sb in the astrophysical $i$-process, providing new constraints on the uncertainties of the resulting chemical abundances from multi-zone low-metallicity Asymptotic Giant Branch stellar models.Comment: 27 pages, 14 pages. Submitted to Physical Review C journal on 13 November 202

A Parameter Study of Type II Supernova Light Curves Using 6 M_odot He Cores

Results of numerical calculations of Type II supernova light curves are presented. The model progenitor stars have 6 $M{_\odot}$ cores and various envelopes, originating from a numerically evolved 20 $M{_\odot}$ star. Five parameters that affect the light curves are examined: the ejected mass, the progenitor radius, the explosion energy, the $^{56}$Ni mass, and the extent of $^{56}$Ni mixing. The following affects have been found: 1) the larger the progenitor radius the brighter the early--time light curve, with little affect on the late--time light curve, 2) the larger the envelope mass the fainter the early light curve and the flatter the slope of the late light curve, 3) the larger the explosion energy the brighter the early light curve and the steeper the slope of the late light curve, 4) the larger the $^{56}$Ni mass the brighter the overall light curve after 20 to 50 days, with no affect on the early light curve, 5) the more extensive the $^{56}$Ni mixing the brighter the early light curve and the steeper the late light curve. The primary parameters affecting the light curve shape are the progenitor radius and the ejected mass. The secondary parameters are the explosion energy, $^{56}$Ni mass and $^{56}$Ni mixing. I find that while in principle the general shape and absolute magnitude of a light curve indicate a unique set of parameters, in practice it is difficult to avoid some ambiguity in the parameters. I find that the nickel--powered diffusion wave and the recombination of helium produce a prominent secondary peak in all our calculations. The feature is less prominent when compositional mixing, both $^{56}$Ni mixing and mixing between the hydrogen and helium layers, occurs. The model photospheric temperatures and velocities are presented, for comparison to observation.Comment: 39 pages, 15 figures. Astrophysical Journal (Accepted, Dec. 20, 2004

Isospin Character of the Pygmy Dipole Resonance in 124Sn

The pygmy dipole resonance has been studied in the proton-magic nucleus 124Sn with the (a,a'g) coincidence method at E=136 MeV. The comparison with results of photon-scattering experiments reveals a splitting into two components with different structure: one group of states which is excited in (a,a'g) as well as in (g,g') reactions and a group of states at higher energies which is only excited in (g,g') reactions. Calculations with the self-consistent relativistic quasiparticle time-blocking approximation and the quasiparticle phonon model are in qualitative agreement with the experimental results and predict a low-lying isoscalar component dominated by neutron-skin oscillations and a higher-lying more isovector component on the tail of the giant dipole resonance

ПИТАННЯ КОМУНІКАТИВНИХ КОМПЕТЕНЦІЙ У ПІДГОТОВЦІ ФАХІВЦІВ ГРОМАДСЬКОГО ЗДОРОВ’Я

The aim of the work – to find out the role and the place of communication issues in the training programs of public health specialists at European and other world-class universities in order to substantiate the relevant educational regulations in Ukraine.The main body. Communication skills in public health are used in such fields as education, medical journalism, outreach in the media, the show business, interpersonal communication, communication within organizations and between them, information dissemination on risks, crises and emergencies, social communication and social marketing.Possible forms of communication are multimedia, interactive, traditional. The choice of communication form should take into account target audiences, cultural assumptions, etc., and should include interpersonal communication, the coverage of a small population base, mass-communication channels, considering television, radio, newspapers. Current forms of communication are the usage of blogs, video sharing, mobile phone service, online forums. Herewith, the communication process should be preceded by the adaptation of information about wide range of public health issues to the specifics of concrete consuming publics.Public health specialist should know and master communication technologies as it is a guarantee of effective counteraction to unhealthy behavior pattern and unwholesome products, including alcohol and tobacco.The feedback receipt is critical to successful implementation of communication in public health and it requires the ability to listen, receive and analyze information about people’s perceptions of messages for improving communication processes.The study of Bachelors’ and Masters’ Public Health Training Programs revealed that a considerable amount of time was spent on studying communication in Poland, Bulgaria, Hungary, and in the USA.Conclusions. Mastering of communicative competence is essential for the effective performance of public health specialists, as evidenced by the conceptual conditions of a number of world-class strategic documents and manifestos.As the Association of Public Health Schools of the European Region listed communicative competences on the main competences of public health, it indicates the need to ensure the communicative competence acquisition in the process of public health staff training.Formation of curricula and training programs for Bachelors and Masters in Public Health in Ukraine should be carried out taking into account the national context, international organizations recommendations and best foreign experience.Мета роботи – з’ясувати роль і місце питань комунікації в навчальних планах та програмах підготовки фахівців громадського здоров’я у вищих навчальних закладах країн Європи і світу для обґрунтування відповідних освітніх нормативних документів в Україні.Основна частина. Сфери застосування комунікаційних навичок у питаннях громадського здоров’я включають освіту, медичну журналістику, інформаційно-роз’яснювальну діяльність у засобах масової інформації, індустрію розваг, міжособистісне спілкування, комунікацію всередині організацій і між ними, поширення інформації про ризики, кризи і надзвичайні події, соціальну комунікацію і соціальний маркетинг.Можливими формами комунікації є мультимедійні, інтерактивні, традиційні. Вибір форми комунікації повинен враховувати цільові аудиторії, культурні особливості тощо і включати міжособистісне спілкування, охоплення незначної чисельності населення, масові канали, включаючи телебачення, радіо, газети. Сучасними формами комунікації є використання блогів, обмін відеоматеріалами, мобільний телефонний зв’язок, онлайнові форуми. При цьому процесу комунікації повинна передувати адаптація інформації з різнобічних питань громадського здоров’я до особливостей конкретних груп споживачів.Знання фахівцями громадського здоров’я комунікаційних технологій та володіння ними є запорукою ефективної протидії нездоровим формам поведінки і шкідливої для здоров’я продукції, зокрема алкоголю, тютюну. Вагомою умовою для успішної  реалізації комунікацій у громадському здоров’ї є отримання зворотного зв’язку, що потребує вміння слухати, отримувати й аналізувати інформацію про сприйняття людьми меседжів для удосконалення комунікаційних процесів.Дослідження планів підготовки бакалаврів та магістрів громадського здоров’я виявило, що вивченню питань комунікації відведено значний обсяг часу в Польщі, болгарії, угорщині, США.Висновки. Володіння комунікативними компетенціями має важливе значення для забезпечення ефективної діяльності фахівців громадського здоров’я, що підтверджено концептуальними положеннями низки стратегічних та програмних документів міжнародного рівня.Включення Асоціацією шкіл громадського здоров’я Європейського регіону комунікаційних компетенцій до основних компетенцій громадського здоров’я свідчить про необхідність забезпечення їх набуття в процесі навчання кадрів для громадського здоров’я.Формування навчальних планів та програм підготовки бакалаврів і магістрів громадського здоров’я в Україні доцільно здійснювати з урахуванням національного контексту, рекомендацій міжнародних організацій та кращого зарубіжного досвіду

GLAUCOMA PROGRESSION. IMPACT OF RISK FACTORS ON THE DISEASE

The aim of the study is to assess the effect of systemic and local risk factors on the rate of glaucoma progression, the specificity and informative nature of ophthalmological studies for assessment of the rate of glaucoma progression.Material and methods. A retrospective analysis of the medical case histories and outpatient charts of 217 patients (268 eyes) for the period from 2014 to 2017 was conducted. The patients with primary open-angle glaucoma having at least 5 Humphrey field-of-view (24-2) studies and optic coherence tomography of the optic nerve disk and retina with a guided progression analysis (GPA) function (SD-OCT) were included in the study. The patients were divided into 2 groups: with rapid progression (more than 1 dB per year, 144 eyes (103 patients)) and slow progression (less than 1 dB per year, 124 eyes (114 patients)). The data of standard ophthalmological methods of investigation (visometry, ophthalmoscopy, biomicroscopy, measurement of intraocular pressure (IOP) according to Maklakov) were additionally analyzed. Demographic and clinical data were assessed: gender, age, cornea central thickness, refraction, IOP, glucocorticosteroid intake, cardiovascular diseases presence, arterial hypertension, arterial hypotension, local hypotensive therapy. Results and discussion. The analysis revealed the main risk factors in glaucoma progression, which include age, cardiovascular diseases presence, high initial IOP values, pronounced functional changes in thevisual fields (lower mean deviation), pseudoexfoliation syndrome

НЕОБХІДНІСТЬ РОЗВИТКУ УКРАЇНСЬКОЇ ТЕЛЕМЕДИЦИНИ ЗА СУЧАСНИХ УМОВ

Purpose: to analyze the degree and necessity of development of telemedicine in modern conditions. Materials and Methods. Using the method of system analysis, the study of the state and necessity of the use of telemedicine in the leading countries of the world and Ukraine was carried out. Results. This article analyzes the degree and need for the development of telemedicine in modern conditions. The main types of telemedicine services, the main directions of telemedicine centers are considered. The introduction of telemedicine in the regions of Ukraine and in foreign countries is estimated. It is optimal to create regional centers around which the telemedicine infrastructure of the region is formed and the system extends to outpatient clinics and medical and obstetric points. Telemedicine centers can be established on the basis of medical institutions, educational or research centers, or as independent commercial or non-commercial organizations. In military medicine, telemedicine technologies are able to simplify the work of doctors, perform effective management during the evacuation stages, systematize and standardize the quality of medical care. The use of telemedicine gives positive results for both patients and healthcare professionals. Patients have the opportunity to conduct remote consultations, consultations (teleconferences) by narrow specialists in remote medical institutions, reduce the time of examination, speed up the transfer of information about the results of examinations between different specialized clinics without the need to transport the patient (especially in emergencies). Telemedicine technologies can be used in almost any medical field: in pediatrics, psychotherapy, dermatology, neurology or resuscitation. In the context of the fight against COVID-19, more and more medical institutions in Ukraine are joining the format of remote video consultations, which allows to preserve the health of doctors and patients, as well as to interact with doctors and colleagues in particularly difficult cases. Conclusions. The use of telemedicine in modern realities has become widespread in many countries around the world, regardless of their economic development. The introduction of telemedicine in Ukraine requires regulatory support, staff training, information support, and its material support falls on public authorities and united territorial communities.Мета: проаналізувати ступінь  і необхідність розвитку телемедицини за сучасних умов. Матеріали і методи. Використовуючи метод системного аналізу, проведено вивчення стану та необхідності використання телемедицини в провідних країнах світу та Україні. Результати. Проаналізовано ступінь і необхідність розвитку телемедицини за сучасних умов. Розглянуто основні види телемедичних послуг, основні напрямки роботи телемедичних центрів. Оцінено впровадження телемедицини в областях України та в зарубіжних країнах. Оптимальним є створення регіональних центрів, навколо яких формується телемедична інфраструктура регіону і система поширюється до лікарських амбулаторій та фельдшерсько-акушерських пунктів. Телемедичні центри можуть створюватися на базі медичних закладів, навчальних чи наукових центрів, або як самостійні комерційні чи некомерційні організації. У військовій медицині телемедичні технології здатні спростити роботу лікарів, виконати ефективний менеджмент на етапах евакуації, систематизувати та стандартизувати якість надання медичної допомоги. Використання телемедицини дає позитивні результати як для пацієнтів, так і для медичних працівників. Для пацієнтів з’являється можливість проведення дистанційних консультацій, консиліумів (телеконференцій) вузькими спеціалістами в територіально віддалених медичних установах, зменшення термінів обстеження, прискорення передачі інформації про результати обстежень між різними спеціалізованими клініками без необхідності транс­портування хворого (особливо в невідкладних станах). Телемедичні технології можна застосовувати майже в будь-якій медичній сфері: в педіатрії, психотерапії, дерматології, неврології або реаніматології. За умов боротьби з COVID-19 все більше медзакладів України долучаються до формату дистанційних відеоконсультацій, що дозволяє зберегти здоров’я лікарів і пацієнтів, а також взаємодіяти лікарям із колегами в особливо складних випадках. Висновки. Використання телемедицини в сучасних реаліях набуло значного поширення у багатьох країнах світу незалежно від їх економічного розвитку. Запровадження телемедицини в Україні потребує нормативно-правової підтримки, навчання персоналу, інфор­ма­ційного забезпечення, а її матеріальне забезпечення лягає на державні органи влади та об’єднані територіальні громади

Antioxidants of Belgorod State University Botanical Garden Plants: Ribes Aureum Fruits Anthocyanins

According to the results of the study, it was found that currant berries of this species contain four main anthocyanins: delfinidin-3-glucoside, delfinidin-3-rutinroside, cyanidin-3-glucoside and cyanidin-3-rutinosid