Novel duplex vapor-electrochemical method for silicon solar cells

Silicon obtained by the SiF4-Na reaction was analyzed by spark source mass spectrometry (SSMS). Silicon samples prepared from induction melted powder were evaluated for electrical properties using four point probe conductivity and thermoelectric methods. SiF4-Na reaction under P sub SiF4 greater than 1 atmosphere. The amount of silicon produced was increased from 25 g per batch (in the glass reactor) to greater than 70 g per batch in the stainless steel reactor. The study of the effects of reaction variables such as P sub SiF4 and maximum temperature attained on the particle size of silicon powder showed that the silicon particle size tends to grow larger with increasing pressure of the SiF4 gas in the reaction system

Novel duplex vapor-electrochemical method for silicon solar cells

Silicon was produced by alternate pulse feeding of the reactants SiF4 gas and liquid sodium. The average temperature in the reactor could be controlled, by regulating the amount of reactant in each pulse. Silicon tetrafluoride gas was analyzed by mass spectrometry to determine the nature and amount of contained volatile impurities which included silicon oxyfluorides, sulfur oxyfluorides, and sulfur dioxide. Sodium metal was analyzed by emission spectrography, and it was found to contain only calcium and copper as impurities

Indian psychiatric interview schedule (IPIS)

The paper discusses the advantages of the structured interview in psychiatric research and goes on to describe the details of development of a structured interview Schedule (IPIS) suitable for an Indian setting. The Schedule is described, as well as the results of interinvestigator reliability tests. Possible uses of the instrument and the necessary further developments are outlined

Factors affecting the reporting of mental disorder in others

The paper describes a study demonstrating that the screening of a few members of the population and asking them about the distribution of psychiatric symptoms in total population is a very inadequate way of discovering the real prevalence rates. The analysis shows that people report symptoms more amongst those who are socially and geographically close to them and amongst the members of their own sex. The characteristics of the 'reporters' are analysed and the results show that the young, the rich, the highly educated and those belonging to more advanced sections of the society are more prone to reporting symptoms in others. The most interesting finding is that those who have psychiatric symptoms themselves report symptoms in others more than those who are symptom-free

Indian psychiatric survey schedule (IPSS)

The paper describes the development of Indian Psychiatric Survey Schedule (IPSS) which is designed to inquire about the presence of 124 psychiatric symptoms and 10 items of historical information in the general population. The symptoms as well as the items of historical information are the same as those in IPIS (Kapur et al., 1974) but because of a multi-stage procedure adopted with IPSS, the inquiry takes much less time than that for IPIS. - A "preliminary interview schedule" which is meant for all members of the population can be used by a nonpsychiatrist after a short period of training. The other sections in IPSS, that is "detailed inquiry with the subject", "detailed inquiry with an informant" and "observations during interview" are completed when necessary by a trained psychiatrist who also gives a physical examination when somatic symptoms are reported. - The paper describes the reasons why a multi-stage procedure was designed, a pilot study which helped reach certain decisions regarding the construction of the schedule and the results of a study carried out to test the level of agreement obtained when three non-psychiatrists (after a short period of training) and a psychiatrist used the preliminary interview schedule with 40 hospital patients and 40 members of the general population

Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells.

Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML). Inhibitors to FLT3 have already been tested in clinical trials, however, drug resistance limits clinical efficacy. Mutant receptor tyrosine kinases are mislocalized in the endoplasmic reticulum (ER) of AML and play an important role in the non-canonical activation of signal transducer and activator of transcription 5 (STAT5). Here, we have tested a potent new drug called imipramine blue (IB), which is a chimeric molecule with a dual mechanism of action. At 200-300 nM concentrations, IB is a potent inhibitor of STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhibition. However, at 75-150 nM concentrations, IB was highly effective at killing mutant FLT3-driven AML cells through a similar mechanism as thapsigargin (TG), involving increased cytosolic calcium. IB also potently inhibited survival of primary human FLT3/ITD+ AML cells compared to FLT3/ITDneg cells and spared normal umbilical cord blood cells. Therefore, IB functions through a mechanism involving vulnerability to dysregulated calcium metabolism and the combination of fusing a lipophilic amine to a NOX inhibiting dye shows promise for further pre-clinical development for targeting high risk AML

Characterization and expression analysis of Staphylococcus aureus pathogenicity island 3 - Implications for the evolution of staphylococcal pathogenicity islands

We describe the complete sequence of the 15.9-kb staphylococcal pathogenicity island 3 encoding staphylococcal enterotoxin serotypes B, K, and Q. The island, which meets the generally accepted definition of pathogenicity islands, contains 24 open reading frames potentially encoding proteins of more than 50 amino acids, including an apparently functional integrase. The element is bordered by two 17-bp direct repeats identical to those found flanking staphylococcal pathogenicity island 1. The island has extensive regions of homology to previously described pathogenicity islands, particularly staphylococcal pathogenicity islands 1 and bov. The expression of 22 of the 24 open reading frames contained on staphylococcal pathogenicity island 3 was detected either in vitro during growth in a laboratory medium or serum or in vivo in a rabbit model of toxic shock syndrome using DNA microarrays. The effect of oxygen tension on staphylococcal pathogenicity island 3 gene expression was also examined. By comparison with the known staphylococcal pathogenicity islands in the context of gene expression described here, we propose a model of pathogenicity island origin and evolution involving specialized transduction events and addition, deletion, or recombination of pathogenicity island "modules.