83 research outputs found
Exposure to animals and risk of oligoarticular juvenile idiopathic arthritis: a multicenter case-control study
<p>Abstract</p> <p>Background</p> <p>An inverse association between early contact with microbial compounds and respiratory allergies is well established. The protective effect of infant contact with animals was also shown for inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE). We aimed to test the association between animal contact in infancy and oligoarticular juvenile idiopathic arthritis (OA JIA).</p> <p>Methods</p> <p>Parents of children with OA JIA registered at the Hospital for Pediatric Rheumatology in Garmisch-Partenkirchen were asked to complete a questionnaire. Children who underwent strabismus surgery at six referral centers for ophthalmology served as controls. Children age 6 to 18 years born in Germany without malformations were included (238 cases; response 89% and 832 controls; response 86%). Data were analyzed using logistic regression models after adjusting for potential confounders.</p> <p>Results</p> <p>Neither place of living (urban vs. rural area), living on a farm, nor regular farm animal (adjusted odds ratio 0.79; 95% confidence interval 0.42-1.47) or pet contact (0.79; 0.55-1.14) during infancy were clearly related to case status. Allergic rhinitis was inversely related to OA JIA (0.57; 0.34-0.95).</p> <p>Neither place of living (urban vs. rural area), living on a farm, nor regular farm animal (adjusted odds ratio 0.79; 95% confidence interval 0.42-1.47) or pet contact (0.79; 0.55-1.14) during infancy were related to case status. Allergic rhinitis was inversely related to OA JIA (0.57; 0.34-0.95).</p> <p>Conclusions</p> <p>Contact with farm environments in infancy might not be associated with OA JIA. This finding is consistent with previous findings for diabetes mellitus type 1 but contradicts results for IBD and SLE.</p
Measurement of the 8B solar neutrino flux in SNO+ with very low backgrounds
A measurement of the 8B solar neutrino flux has been made using a 69.2 kt-day dataset acquired with the SNO+ detector during its water commissioning phase. At energies above 6 MeV the dataset is an extremely pure sample of solar neutrino elastic scattering events, owing primarily to the detector’s deep location, allowing an accurate measurement with relatively little exposure. In that energy region the best fit background rate is 0.25+0.09−0.07  events/kt−day, significantly lower than the measured solar neutrino event rate in that energy range, which is 1.03+0.13−0.12  events/kt−day. Also using data below this threshold, down to 5 MeV, fits of the solar neutrino event direction yielded an observed flux of 2.53+0.31−0.28(stat)+0.13−0.10(syst)×106  cm−2 s−1, assuming no neutrino oscillations. This rate is consistent with matter enhanced neutrino oscillations and measurements from other experiments
Measurement of neutron-proton capture in the SNO+ water phase
The SNO+ experiment collected data as a low-threshold water Cherenkov
detector from September 2017 to July 2019. Measurements of the 2.2-MeV
produced by neutron capture on hydrogen have been made using an Am-Be
calibration source, for which a large fraction of emitted neutrons are produced
simultaneously with a 4.4-MeV . Analysis of the delayed coincidence
between the 4.4-MeV and the 2.2-MeV capture revealed a
neutron detection efficiency that is centered around 50% and varies at the
level of 1% across the inner region of the detector, which to our knowledge is
the highest efficiency achieved among pure water Cherenkov detectors. In
addition, the neutron capture time constant was measured and converted to a
thermal neutron-proton capture cross section of mb
Observation of Antineutrinos from Distant Reactors using Pure Water at SNO+
The SNO+ collaboration reports the first observation of reactor antineutrinos
in a Cherenkov detector. The nearest nuclear reactors are located 240 km away
in Ontario, Canada. This analysis used events with energies lower than in any
previous analysis with a large water Cherenkov detector. Two analytical methods
were used to distinguish reactor antineutrinos from background events in 190
days of data and yielded consistent observations of antineutrinos with a
combined significance of 3.5 .Comment: v2: add missing author, add link to supplemental materia
Improved search for invisible modes of nucleon decay in water with the SNO+ detector
This paper reports results from a search for single and multi-nucleon
disappearance from the O nucleus in water within the \snoplus{} detector
using all of the available data. These so-called "invisible" decays do not
directly deposit energy within the detector but are instead detected through
their subsequent nuclear de-excitation and gamma-ray emission. New limits are
given for the partial lifetimes:
years, years, years,
years, and years at 90\% Bayesian
credibility level (with a prior uniform in rate). All but the () results improve on existing limits by a factor of about 3.info:eu-repo/semantics/publishedVersio
Intra-peritoneal administration of Ecballium elaterium diminishes postoperative adhesions
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