The relation between solar cell flight performance data and materials and manufacturing data Final report

Flight performance data for solar cell power systems in satellites and correlation with manufacturing methods and material

Circumnuclear Star Clusters in the Galaxy Merger NGC 6240, Observed with Keck Adaptive Optics and HST

We discuss images of the central ~10 kpc (in projection) of the galaxy merger NGC 6240 at H and K' bands, taken with the NIRC2 narrow camera on Keck II using natural guide star adaptive optics. We detect 28 star clusters in the NIRC2 images, of which only 7 can be seen in the similar-spatial-resolution, archival WFPC2 Planetary Camera data at either B or I bands. Combining the NIRC2 narrow camera pointings with wider NICMOS NIC2 images taken with the F110W, F160W, and F222M filters, we identify a total of 32 clusters that are detected in at least one of these 5 infrared (lambda > 1 micron) bandpasses. By comparing to instantaneous burst, stellar population synthesis models (Bruzual & Charlot 2003), we estimate that most of the clusters are consistent with being ~15 Myr old and have photometric masses ranging from 7E5 M_sun to 4E7 M_sun. The total contribution to the star formation rate (SFR) from these clusters is approximately 10 M_sun/year, or ~10% of the total SFR in the nuclear region. We use these newly discovered clusters to estimate the extinction toward NGC 6240's double nuclei, and find values of A_V as high as 14 magnitudes along some sightlines, with an average extinction of A_V~7 mag toward sightlines within ~3 arcsec of the double nuclei.Comment: 37 pages, 9 figures; Accepted for publication by Ap

VLBI Polarimetry of 177 Sources from the Caltech-Jodrell Bank Flat-spectrum Survey

We present VLBA observations and a statistical analysis of 5 GHz VLBI polarimetry data from 177 sources in the Caltech-Jodrell Bank flat-spectrum (CJF) survey. The CJF survey, a complete, flux-density-limited sample of 293 extragalactic radio sources, gives us the unique opportunity to compare a broad range of source properties for quasars, galaxies and BL Lacertae objects. We focus primarily on jet properties, specifically the correlation between the jet axis angle and the polarization angle in the core and jet. A strong correlation is found for the electric vector polarization angle in the cores of quasars to be perpendicular to the jet axis. Contrary to previous claims, no correlation is found between the jet polarization angle and the jet axis in either quasars or BL Lac objects. With this large, homogeneous sample we are also able to investigate cosmological issues and AGN evolution.Comment: Accepted to the Astrophysical Journal: 37 pages, 14 figure

Collective excitation of a Bose-Einstein condensate by modulation of the atomic scattering length

We excite the lowest-lying quadrupole mode of a Bose-Einstein condensate by modulating the atomic scattering length via a Feshbach resonance. Excitation occurs at various modulation frequencies, and resonances located at the natural quadrupole frequency of the condensate and at the first harmonic are observed. We also investigate the amplitude of the excited mode as a function of modulation depth. Numerical simulations based on a variational calculation agree with our experimental results and provide insight into the observed behavior.Comment: Submitted to PR

Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers.

BACKGROUND: Ticagrelor is an oral P2Y12 inhibitor that is used with aspirin to reduce the risk of ischemic events among patients with acute coronary syndromes or previous myocardial infarction. Spontaneous major bleeding and bleeding associated with urgent invasive procedures are concerns with ticagrelor, as with other antiplatelet drugs. The antiplatelet effects of ticagrelor cannot be reversed with platelet transfusion. A rapid-acting reversal agent would be useful. METHODS: In this randomized, double-blind, placebo-controlled, phase 1 trial, we evaluated intravenous PB2452, a monoclonal antibody fragment that binds ticagrelor with high affinity, as a ticagrelor reversal agent. We assessed platelet function in healthy volunteers before and after 48 hours of ticagrelor pretreatment and again after the administration of PB2452 or placebo. Platelet function was assessed with the use of light transmission aggregometry, a point-of-care P2Y12 platelet-reactivity test, and a vasodilator-stimulated phosphoprotein assay. RESULTS: Of the 64 volunteers who underwent randomization, 48 were assigned to receive PB2452 and 16 to receive placebo. After 48 hours of ticagrelor pretreatment, platelet aggregation was suppressed by approximately 80%. PB2452 administered as an initial intravenous bolus followed by a prolonged infusion (8, 12, or 16 hours) was associated with a significantly greater increase in platelet function than placebo, as measured by multiple assays. Ticagrelor reversal occurred within 5 minutes after the initiation of PB2452 and was sustained for more than 20 hours (P\u3c0.001 after Bonferroni adjustment across all time points for all assays). There was no evidence of a rebound in platelet activity after drug cessation. Adverse events related to the trial drug were limited mainly to issues involving the infusion site. CONCLUSIONS: In healthy volunteers, the administration of PB2452, a specific reversal agent for ticagrelor, provided immediate and sustained reversal of the antiplatelet effects of ticagrelor, as measured by multiple assays. (Funded by PhaseBio Pharmaceuticals; ClinicalTrials.gov number, NCT03492385.)

Multipole structure and coordinate systems

Multipole expansions depend on the coordinate system, so that coefficients of multipole moments can be set equal to zero by an appropriate choice of coordinates. Therefore, it is meaningless to say that a physical system has a nonvanishing quadrupole moment, say, without specifying which coordinate system is used. (Except if this moment is the lowest non-vanishing one.) This result is demonstrated for the case of two equal like electric charges. Specifically, an adapted coordinate system in which the potential is given by a monopole term only is explicitly found, the coefficients of all higher multipoles vanish identically. It is suggested that this result can be generalized to other potential problems, by making equal coordinate surfaces coincide with the potential problem's equipotential surfaces.Comment: 2 figure

A Compact Supermassive Binary Black Hole System

We report on the discovery of a supermassive binary black hole system in the radio galaxy 0402+379, with a projected separation between the two black holes of just 7.3 pc. This is the closest black hole pair yet found by more than two orders of magnitude. These results are based upon recent multi-frequency observations using the Very Long Baseline Array (VLBA) which reveal two compact, variable, flat-spectrum, active nuclei within the elliptical host galaxy of 0402+379. Multi-epoch observations from the VLBA also provide constraints on the total mass and dynamics of the system. Low spectral resolution spectroscopy using the Hobby-Eberly Telescope indicates two velocity systems with a combined mass of the two black holes of ~1.5 x 10^8 solar masses. The two nuclei appear stationary while the jets emanating from the weaker of the two nuclei appear to move out and terminate in bright hot spots. The discovery of this system has implications for the number of close binary black holes that might be sources of gravitational radiation. Green Bank Telescope observations at 22 GHz to search for water masers in this interesting system are also presented.Comment: 34 pages, 7 figures, Accepted to The Astrophysical Journa

Effect of Albumin on the Biliary Clearance of Compounds in Sandwich-Cultured Rat Hepatocytes

The purpose of the present study was to evaluate the effects of bovine serum albumin (BSA) and essentially fatty acid-free BSA (BSA-FAF) on the biliary clearance of compounds in sandwich-cultured rat hepatocytes. Unbound fraction (fu), biliary excretion index (BEI), and unbound intrinsic biliary clearance (intrinsic Cl’biliary) were determined for digoxin, pravastatin, and taurocholate in the absence or presence of BSA or BSA-FAF. BSA had little effect on the BEI or intrinsic Cl’biliary of these compounds. Surprisingly, BSA-FAF decreased both BEI and intrinsic Cl’biliary for digoxin and pravastatin, which represent low and moderately-bound compounds, respectively. The BEI and intrinsic Cl’biliary of taurocholate, a highly-bound compound, were not altered significantly by BSA-FAF. Neither BSA nor BSA-FAF had a discernable effect on the bile canalicular networks, based on carboxydichlorofluorescein (CDF) retention. The addition of physiological concentrations of calcium, or the addition of fatty acids to BSA-FAF, was unable to restore the BEI or intrinsic Cl’biliary of the model compounds to similar values in the absence or presence of BSA. Careful consideration is warranted when selecting the type of BSA for addition to in vitro systems such as sandwich-cultured rat hepatocytes

Quantum simulations of the superfluid-insulator transition for two-dimensional, disordered, hard-core bosons

We introduce two novel quantum Monte Carlo methods and employ them to study the superfluid-insulator transition in a two-dimensional system of hard-core bosons. One of the methods is appropriate for zero temperature and is based upon Green's function Monte Carlo; the other is a finite-temperature world-line cluster algorithm. In each case we find that the dynamical exponent is consistent with the theoretical prediction of $z=2$ by Fisher and co-workers.Comment: Revtex, 10 pages, 3 figures (postscript files attached at end, separated by %%%%%% Fig # %%%%%, where # is 1-3). LA-UR-94-270