Discrete Symmetries of Off-Shell Electromagnetism

We discuss the discrete symmetries of the Stueckelberg-Schrodinger relativistic quantum theory and its associated 5D local gauge theory, a dynamical description of particle/antiparticle interactions, with monotonically increasing Poincare-invariant parameter. In this framework, worldlines are traced out through the parameterized evolution of spacetime events, advancing or retreating with respect to the laboratory clock, with negative energy trajectories appearing as antiparticles when the observer describes the evolution using the laboratory clock. The associated gauge theory describes local interactions between events (correlated by the invariant parameter) mediated by five off-shell gauge fields. These gauge fields are shown to transform tensorially under under space and time reflections, unlike the standard Maxwell fields, and the interacting quantum theory therefore remains manifestly Lorentz covariant. Charge conjugation symmetry in the quantum theory is achieved by simultaneous reflection of the sense of evolution and the fifth scalar field. Applying this procedure to the classical gauge theory leads to a purely classical manifestation of charge conjugation, placing the CPT symmetries on the same footing in the classical and quantum domains. In the resulting picture, interactions do not distinguish between particle and antiparticle trajectories -- charge conjugation merely describes the interpretation of observed negative energy trajectories according to the laboratory clock.Comment: 26 page

Methodology for urban rail and construction technology research and development planning

A series of transit system visits, organized by the American Public Transit Association (APTA), was conducted in which the system operators identified the most pressing development needs. These varied by property and were reformulated into a series of potential projects. To assist in the evaluation, a data base useful for estimating the present capital and operating costs of various transit system elements was generated from published data. An evaluation model was developed which considered the rate of deployment of the research and development project, potential benefits, development time and cost. An outline of an evaluation methodology that considered benefits other than capital and operating cost savings was also presented. During the course of the study, five candidate projects were selected for detailed investigation; (1) air comfort systems; (2) solid state auxiliary power conditioners; (3) door systems; (4) escalators; and (5) fare collection systems. Application of the evaluation model to these five examples showed the usefulness of modeling deployment rates and indicated a need to increase the scope of the model to quantitatively consider reliability impacts

Engaging and empowering first-year students through curriculum design: perspectives from the literature

There is an increasing value being placed on engaging and empowering first-year students and first-year curriculum design is a key driver and opportunity to ensure early enculturation into successful learning at university. This paper summarises the literature on first-year curriculum design linked to student engagement and empowerment. We present conceptualisations of ‘curriculum’ and examples from first-year curriculum design. We also note the limited literature where students have been involved in designing first-year curricula. The results of the literature review suggest that key characteristics of engaging first-year curricula include active learning, timely feedback, relevance and challenge. The literature also points to the importance of identifying students' abilities on entry to university as well as being clear about desired graduate attributes and developmental goals. Acknowledging realities and constraints, we present a framework for the first-year curriculum design process based on the literature

Metabolic and hormonal studies of Type 1 (insulin-dependent) diabetic patients after successful pancreas and kidney transplantation

Long-term normalization of glucose metabolism is necessary to prevent or ameliorate diabetic complications. Although pancreatic grafting is able to restore normal blood glucose and glycated haemoglobin, the degree of normalization of the deranged diabetic metabolism after pancreas transplantation is still questionable. Consequently glucose, insulin, C-peptide, glucagon, and pancreatic polypeptide responses to oral glucose and i.v. arginine were measured in 36 Type 1 (insulin-dependent) diabetic recipients of pancreas and kidney allografts and compared to ten healthy control subjects. Despite normal HbA1 (7.2±0.2%; normal <8%) glucose disposal was normal only in 44% and impaired in 56% of the graft recipients. Normalization of glucose tolerance was achieved at the expense of hyperinsulinaemia in 52% of the subjects. C-peptide and glucagon were normal, while pancreatic polypeptide was significantly higher in the graft recipients. Intravenous glucose tolerance (n=21) was normal in 67% and borderline in 23%. Biphasic insulin release was seen in patients with normal glucose tolerance. Glucose tolerance did not deteriorate up to 7 years post-transplant. In addition, stress hormone release (cortisol, growth hormone, prolactin, glucagon, catecholamines) to insulin-induced hypoglycaemia was examined in 20 graft recipients and compared to eight healthy subjects. Reduced blood glucose decline indicates insulin resistance, but glucose recovery was normal, despite markedly reduced catecholamine and glucagon release. These data demonstrate the effectiveness of pancreatic grafting in normalizing glucose metabolism, although hyperinsulinaemia and deranged counterregulatory hormone response are observed frequently

Footprints of Statistical Anisotropies

We propose and develop a formalism to describe and constrain statistically anisotropic primordial perturbations. Starting from a decomposition of the primordial power spectrum in spherical harmonics, we find how the temperature fluctuations observed in the CMB sky are directly related to the coefficients in this harmonic expansion. Although the angular power spectrum does not discriminate between statistically isotropic and anisotropic perturbations, it is possible to define analogous quadratic estimators that are direct measures of statistical anisotropy. As a simple illustration of our formalism we test for the existence of a preferred direction in the primordial perturbations using full-sky CMB maps. We do not find significant evidence supporting the existence of a dipole component in the primordial spectrum.Comment: 26 pages, 5 double figures. Uses RevTeX

Joint Learning of Intrinsic Images and Semantic Segmentation

Semantic segmentation of outdoor scenes is problematic when there are variations in imaging conditions. It is known that albedo (reflectance) is invariant to all kinds of illumination effects. Thus, using reflectance images for semantic segmentation task can be favorable. Additionally, not only segmentation may benefit from reflectance, but also segmentation may be useful for reflectance computation. Therefore, in this paper, the tasks of semantic segmentation and intrinsic image decomposition are considered as a combined process by exploring their mutual relationship in a joint fashion. To that end, we propose a supervised end-to-end CNN architecture to jointly learn intrinsic image decomposition and semantic segmentation. We analyze the gains of addressing those two problems jointly. Moreover, new cascade CNN architectures for intrinsic-for-segmentation and segmentation-for-intrinsic are proposed as single tasks. Furthermore, a dataset of 35K synthetic images of natural environments is created with corresponding albedo and shading (intrinsics), as well as semantic labels (segmentation) assigned to each object/scene. The experiments show that joint learning of intrinsic image decomposition and semantic segmentation is beneficial for both tasks for natural scenes. Dataset and models are available at: https://ivi.fnwi.uva.nl/cv/intrinsegComment: ECCV 201

The evolution of eyes and visually guided behaviour

The morphology and molecular mechanisms of animal photoreceptor cells and eyes reveal a complex pattern of duplications and co-option of genetic modules, leading to a number of different light-sensitive systems that share many components, in which clear-cut homologies are rare. On the basis of molecular and morphological findings, I discuss the functional requirements for vision and how these have constrained the evolution of eyes. The fact that natural selection on eyes acts through the consequences of visually guided behaviour leads to a concept of task-punctuated evolution, where sensory systems evolve by a sequential acquisition of sensory tasks. I identify four key innovations that, one after the other, paved the way for the evolution of efficient eyes. These innovations are (i) efficient photopigments, (ii) directionality through screening pigment, (iii) photoreceptor membrane folding, and (iv) focusing optics. A corresponding evolutionary sequence is suggested, starting at non-directional monitoring of ambient luminance and leading to comparisons of luminances within a scene, first by a scanning mode and later by parallel spatial channels in imaging eyes

Cosmic Microwave Background, Accelerating Universe and Inhomogeneous Cosmology

We consider a cosmology in which a spherically symmetric large scale inhomogeneous enhancement or a void are described by an inhomogeneous metric and Einstein's gravitational equations. For a flat matter dominated universe the inhomogeneous equations lead to luminosity distance and Hubble constant formulas that depend on the location of the observer. For a general inhomogeneous solution, it is possible for the deceleration parameter to differ significantly from the FLRW result. The deceleration parameter $q_0$ can be interpreted as $q_0 > 0$ ($q_0=1/2$ for a flat matter dominated universe) in a FLRW universe and be $q_0 < 0$ as inferred from the inhomogeneous enhancement that is embedded in a FLRW universe. A spatial volume averaging of local regions in the backward light cone has to be performed for the inhomogeneous solution at late times to decide whether the decelerating parameter $q$ can be negative for a positive energy condition. The CMB temperature fluctuations across the sky can be unevenly distributed in the northern and southern hemispheres in the inhomogeneous matter dominated solution, in agreement with the analysis of the WMAP power spectrum data by several authors. The model can possibly explain the anomalous alignment of the quadrupole and octopole moments observed in the WMAP data.Comment: 20 pages, no figures, LaTex file. Equations and typos corrected and references added. Additional material and some conclusions changed. Final published versio

The programming of sequences of saccades

Saccadic eye movements move the high-resolution fovea to point at regions of interest. Saccades can only be generated serially (i.e., one at a time). However, what remains unclear is the extent to which saccades are programmed in parallel (i.e., a series of such moments can be planned together) and how far ahead such planning occurs. In the current experiment, we investigate this issue with a saccade contingent preview paradigm. Participants were asked to execute saccadic eye movements in response to seven small circles presented on a screen. The extent to which participants were given prior information about target locations was varied on a trial-by-trial basis: participants were aware of the location of the next target only, the next three, five, or all seven targets. The addition of new targets to the display was made during the saccade to the next target in the sequence. The overall time taken to complete the sequence was decreased as more targets were available up to all seven targets. This was a result of a reduction in the number of saccades being executed and a reduction in their saccade latencies. Surprisingly, these results suggest that, when faced with a demand to saccade to a large number of target locations, saccade preparation about all target locations is carried out in paralle

Complete genome sequence of the Medicago microsymbiont Ensifer (Sinorhizobium) medicae strain WSM419

Ensifer (Sinorhizobium) medicae is an effective nitrogen fixing microsymbiont of a diverse range of annual Medicago (medic) species. Strain WSM419 is an aerobic, motile, non-spore forming, Gram-negative rod isolated from a M. murex root nodule collected in Sardinia, Italy in 1981. WSM419 was manufactured commercially in Australia as an inoculant for annual medics during 1985 to 1993 due to its nitrogen fixation, saprophytic competence and acid tolerance properties. Here we describe the basic features of this organism, together with the complete genome sequence, and annotation. This is the first report of a complete genome se-quence for a microsymbiont of the group of annual medic species adapted to acid soils. We reveal that its genome size is 6,817,576 bp encoding 6,518 protein-coding genes and 81 RNA only encoding genes. The genome contains a chromosome of size 3,781,904 bp and 3 plasmids of size 1,570,951 bp, 1,245,408 bp and 219,313 bp. The smallest plasmid is a fea-ture unique to this medic microsymbiont