17 research outputs found
Numerical Solution of a Complete Formulation of Flow in a Perfusion Bone-Tissue Bioreactor Using Lattice Boltzmann Equation Method
We report the key findings from numerical solutions of a model of transport
within an established perfusion bioreactor design. The model includes a
complete formulation of transport with fully coupled convection-diffusion and
scaffold cell attachment. It also includes the experimentally determined
internal (Poly-L-Lactic Acid (PLLA)) scaffold boundary, together with the
external vessel and flow-port boundaries. Our findings, obtained using parallel
lattice Boltzmann equation method, relate to (i) whole-device, steady-state
flow and species distribution and (ii) the properties of the scaffold. In
particular the results identify which elements of the problem may be addressed
by coarse grained methods such as the Darcy approximation and those which
require a more complete description. The work demonstrates that appropriate
numerical modelling will make a key contribution to the design and development
of large scale bioreactors.Comment: 9 pages, 3 figure
Fluid shear stress induces differential gene expression of leukemia inhibitory factor in human mesenchymal stem cells
Modeling and design of optimal flow perfusion bioreactors for tissue engineering applications
Mechanical modulation of nascent stem cell lineage commitment in tissue engineering scaffolds
Thin films of functionalized multiwalled carbon nanotubes as suitable scaffold materials for stem cells proliferation and bone formation
10.1021/nn102738cACS Nano4127717-772