10 research outputs found
Methods to actively modify the dynamic response of cm-scale FWMAV designs
- Author
- Publication venue
- 'IOP Publishing'
- Publication date
- Field of study
Zusammensetzung von schwebstoffen im Elbe aestuar: Bedeutung fĂĽr biologische prozesse und transportverhalten
- Author
- A. Meister
- Arge Elbe (Arbeitsgemeinschaft fĂĽr die Reinhaltung der Elbe)
- Arge Elbe (Arbeitsgemeinschaft fĂĽr die Reinhaltung der Elbe)
- Arge Elbe (Arbeitsgemeinschaft zur Reinhaltung der Elbe)
- B. Köpcke
- C. Moon
- D. Eisma
- D. V. Subba Rao
- H. Kausch
- H. Reincke
- H. Zimmermann-Timm
- J. C Riedel-Lorjé
- J. Ortega
- K. H. Wiltshire
- K. H. Wiltshire
- K. Wolfstein
- K. Wolfstein
- K. Wolfstein
- Kirsten Wolfstein
- L Kies
- Ludwig Kies
- M. Kerner
- M. Kerner
- N. Bernát
- N. Goosen
- N. Greiser
- P. K. Björnsen
- P. M. J. Herman
- R. F. C. Mantoura
- S. Gasparini
- T. Fast
- U. Irmer
- V.N. Jonge De
- X. Irigorien
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Unravelling cell wall formation in the woody dicot stem
- Author
- A-M. Boudet
- A-M. Catesson
- A. Faik
- A. Hejnowicz
- A. Kawaoka
- A. Yoshinaga
- A.-M. Catesson
- A.C.E. Gregory
- A.H. Valster
- A.L.K. Bentum
- A.M. Catesson
- A.M. Catesson
- A.R. Miller
- B. Grimmig
- B. Monties
- B. Seitz
- B. Sundberg
- B. Vian
- B.E. Frewen
- B.J. Fergus
- C. Chen
- C. Domingo
- C. Feuillet
- C. Halpin
- C. Lapierre
- C. Plomion
- C. Ren
- C. Uggla
- C. Uggla
- C. Wulff
- C.-J. Tsai
- C.C.S. Chapple
- C.G. Smith
- C.H. Haigler
- C.H.A. Little
- C.P. Darley
- C.T. Brett
- D. Reis
- D. W. Sheriff
- D.A Bell-Lelong
- D.A.I. Goring
- D.H. Northcote
- D.H. Northcote
- D.J. Cosgrove
- D.J. Cosgrove
- D.M. Gibeaut
- D.P. Delmer
- E. Benjavongku1chai
- E. Campillo
- E. Chen
- E. Ingold
- E. Koopmann
- E. Martz
- E. Zablackis
- E.A. Loewus
- E.J. Klekowski
- E.W. Sinnott
- F. Sitbon
- F.F. Ermel
- F.W. Whitmore
- F.Y. Bib
- G. Dalessandro
- G. Piro
- G. Thskan
- G.F. Zhang
- G.J. McDougall
- G.P. Bolwell
- G.P. Bolwell
- G.P. Bolwell
- G.P. Bolwell
- H. Abe
- H. Fukuda
- H. Fukuda
- H. Fukuda
- H. Kim
- H. Meng
- H. Meyermans
- H. Tuominen
- H. Tuominen
- H. Winter
- H.-J.G. Jung
- H.D. Bradshaw
- H.D. Bradshaw
- H.J. Klee
- I. Couchy
- I.J.W. Bisset
- I.M. Saxena
- I.M. Sussex
- J. Benayoun
- J. Benayoun
- J. Digby
- J. Doorsselaere
- J. Grima-Pettenati
- J. Hafren
- J. Nakashima
- J. Piquemal
- J. Puhlmann
- J. Rajagopal
- J. Ralph
- J. Samaj
- J. Sheen
- J. Zakrzewski
- J.-P. Joseleau
- J.E. Thompson
- J.G. Taylor
- J.G. Torrey
- J.H. Christensen
- J.K.N. Jones
- J.M. Humphreys
- J.M. Marita
- J.P. Knox
- J.P. Knox
- J.R. Barnett
- J.R. Barnett
- J.W. Blount
- K Nishitani
- K-H. Han
- K-H. Han
- K-H. Im
- K. Inoue
- K. Kakegawa
- K. Meyer
- K. Nishitani
- K. Osakabe
- K. Suzuki
- K. Takabe
- K. Vander Mijnsbrugge
- K.-i. Baba
- K.C. Vaughn
- K.S. Dhugga
- L. Eklund
- L. Goosen-de Rao
- L. He
- L. Jones
- L. Jouanin
- L. Li
- L. Li
- L. Tamagnone
- L. Wu
- L.M. Lagrimini
- L.M. Lagrimini
- L.R. Wu
- M. Baucher
- M. Baucher
- M. Baucher
- M. BaĂŻer
- M. Fagard
- M. Fujita
- M. Goto
- M. Kaeiser
- M. Kaeiser
- M. Kaeiser
- M. Torki
- M.-T. Cervera
- M.C. McCann
- M.E. Eriksson
- M.J. Chalmers
- M.M. Campbell
- M.W. Wenham
- N. Chaffey
- N. Holland
- N. Matsui
- N. Terashima
- N. Yahiaoui
- N.C. Carpita
- N.G. Taylor
- N.J. Bate
- N.J. Stacey
- P. Wojtaszek
- P.H. Norberg
- P.R. Larson
- Q. Wang
- R. Aloni
- R. Aloni
- R. Franke
- R. Funada
- R. Goldberg
- R. Perri
- R. Phillips
- R. Tenhaken
- R. Wu
- R. Wu
- R. Wu
- R. Wu
- R. Zhong
- R. Zhong
- R.A. Gregory
- R.E. Kroll
- R.F. Evert
- R.F. Evert
- R.F. Sultze
- R.J. Vietor
- R.M. Perrin
- R.R. Sederoff
- R.S. Dodd
- R.T. Riding
- R.W. Whetten
- S. Abel
- S. Baima
- S. Hauch
- S. Hawkins
- S. Kawamata
- S. Kimura
- S. Maury
- S. McQueen-Mason
- S. Ohta
- S. Rasmussen
- S. Sonobe
- S.C. Mueller
- S.E.C. Whitney
- S.G. Boyce
- S.M. Allina
- S.R. Thrner
- T. Arioli
- T. Awano
- T. Awano
- T. Fujii
- T. Fujii
- T. Fujino
- T. Fukuda
- T. Hayashi
- T. Hibino
- T. Imai
- T. Matsumoto
- T. Moritz
- T. Nobushi
- T. Takeda
- T.A. Gorshkova
- T.S. Potikha
- T.V. Bragina
- V.J.H. Sewalt
- W-J. Hu
- W. Liese
- W. Wloch
- W.-J. Hu
- W.G.T. Willats
- W.G.T. Willats
- Y. Elkind
- Y. Murakami
- Y. Ohmiya
- Y. Shimizu
- Y. Watanabe
- Z.-H. Ye
- Z.-L. Zheng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2001
- Field of study
Unravelling cell wall formation in the woody dicot stem
- Author
- A-M. Boudet
- A-M. Catesson
- A. Faik
- A. Hejnowicz
- A. Kawaoka
- A. Yoshinaga
- A.-M. Catesson
- A.C.E. Gregory
- A.H. Valster
- A.L.K. Bentum
- A.M. Catesson
- A.M. Catesson
- A.R. Miller
- B. Grimmig
- B. Monties
- B. Seitz
- B. Sundberg
- B. Vian
- B.E. Frewen
- B.J. Fergus
- C. Chen
- C. Domingo
- C. Feuillet
- C. Halpin
- C. Lapierre
- C. Plomion
- C. Ren
- C. Uggla
- C. Uggla
- C. Wulff
- C.-J. Tsai
- C.C.S. Chapple
- C.G. Smith
- C.H. Haigler
- C.H.A. Little
- C.P. Darley
- C.T. Brett
- D. Reis
- D. W. Sheriff
- D.A Bell-Lelong
- D.A.I. Goring
- D.H. Northcote
- D.H. Northcote
- D.J. Cosgrove
- D.J. Cosgrove
- D.M. Gibeaut
- D.P. Delmer
- E. Benjavongku1chai
- E. Campillo
- E. Chen
- E. Ingold
- E. Koopmann
- E. Martz
- E. Zablackis
- E.A. Loewus
- E.J. Klekowski
- E.W. Sinnott
- F. Sitbon
- F.F. Ermel
- F.W. Whitmore
- F.Y. Bib
- G. Dalessandro
- G. Piro
- G. Thskan
- G.F. Zhang
- G.J. McDougall
- G.P. Bolwell
- G.P. Bolwell
- G.P. Bolwell
- G.P. Bolwell
- H. Abe
- H. Fukuda
- H. Fukuda
- H. Fukuda
- H. Kim
- H. Meng
- H. Meyermans
- H. Tuominen
- H. Tuominen
- H. Winter
- H.-J.G. Jung
- H.D. Bradshaw
- H.D. Bradshaw
- H.J. Klee
- I. Couchy
- I.J.W. Bisset
- I.M. Saxena
- I.M. Sussex
- J. Benayoun
- J. Benayoun
- J. Digby
- J. Doorsselaere
- J. Grima-Pettenati
- J. Hafren
- J. Nakashima
- J. Piquemal
- J. Puhlmann
- J. Rajagopal
- J. Ralph
- J. Samaj
- J. Sheen
- J. Zakrzewski
- J.-P. Joseleau
- J.E. Thompson
- J.G. Taylor
- J.G. Torrey
- J.H. Christensen
- J.K.N. Jones
- J.M. Humphreys
- J.M. Marita
- J.P. Knox
- J.P. Knox
- J.R. Barnett
- J.R. Barnett
- J.W. Blount
- K Nishitani
- K-H. Han
- K-H. Han
- K-H. Im
- K. Inoue
- K. Kakegawa
- K. Meyer
- K. Nishitani
- K. Osakabe
- K. Suzuki
- K. Takabe
- K. Vander Mijnsbrugge
- K.-i. Baba
- K.C. Vaughn
- K.S. Dhugga
- L. Eklund
- L. Goosen-de Rao
- L. He
- L. Jones
- L. Jouanin
- L. Li
- L. Li
- L. Tamagnone
- L. Wu
- L.M. Lagrimini
- L.M. Lagrimini
- L.R. Wu
- M. Baucher
- M. Baucher
- M. Baucher
- M. BaĂŻer
- M. Fagard
- M. Fujita
- M. Goto
- M. Kaeiser
- M. Kaeiser
- M. Kaeiser
- M. Torki
- M.-T. Cervera
- M.C. McCann
- M.E. Eriksson
- M.J. Chalmers
- M.M. Campbell
- M.W. Wenham
- N. Chaffey
- N. Holland
- N. Matsui
- N. Terashima
- N. Yahiaoui
- N.C. Carpita
- N.G. Taylor
- N.J. Bate
- N.J. Stacey
- P. Wojtaszek
- P.H. Norberg
- P.R. Larson
- Q. Wang
- R. Aloni
- R. Aloni
- R. Franke
- R. Funada
- R. Goldberg
- R. Perri
- R. Phillips
- R. Tenhaken
- R. Wu
- R. Wu
- R. Wu
- R. Wu
- R. Zhong
- R. Zhong
- R.A. Gregory
- R.E. Kroll
- R.F. Evert
- R.F. Evert
- R.F. Sultze
- R.J. Vietor
- R.M. Perrin
- R.R. Sederoff
- R.S. Dodd
- R.T. Riding
- R.W. Whetten
- S. Abel
- S. Baima
- S. Hauch
- S. Hawkins
- S. Kawamata
- S. Kimura
- S. Maury
- S. McQueen-Mason
- S. Ohta
- S. Rasmussen
- S. Sonobe
- S.C. Mueller
- S.E.C. Whitney
- S.G. Boyce
- S.M. Allina
- S.R. Thrner
- T. Arioli
- T. Awano
- T. Awano
- T. Fujii
- T. Fujii
- T. Fujino
- T. Fukuda
- T. Hayashi
- T. Hibino
- T. Imai
- T. Matsumoto
- T. Moritz
- T. Nobushi
- T. Takeda
- T.A. Gorshkova
- T.S. Potikha
- T.V. Bragina
- V.J.H. Sewalt
- W-J. Hu
- W. Liese
- W. Wloch
- W.-J. Hu
- W.G.T. Willats
- W.G.T. Willats
- Y. Elkind
- Y. Murakami
- Y. Ohmiya
- Y. Shimizu
- Y. Watanabe
- Z.-H. Ye
- Z.-L. Zheng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2001
- Field of study
Populus is presented as a model system for the study of wood formation (xylogenesis). The formation of wood (secondary xylem) is an ordered developmental process involving cell division, cell expansion, secondary wall deposition, lignification and programmed cell death. Because wood is formed in a variable environment and subject to developmental control, xylem cells are produced that differ in size, shape, cell wall structure, texture and composition. Hormones mediate some of the variability observed and control the process of xylogenesis. High-resolution analysis of auxin distribution across cambial region tissues, combined with the analysis of transgenic plants with modified auxin distribution, suggests that auxin provides positional information for the exit of cells from the meristem and probably also for the duration of cell expansion. Poplar sequencing projects have provided access to genes involved in cell wall formation. Genes involved in the biosynthesis of the carbohydrate skeleton of the cell wall are briefly reviewed. Most progress has been made in characterizing pectin methyl esterases that modify pectins in the cambial region. Specific expression patterns have also been found for expansins, xyloglucan endotransglycosylases and cellulose synthases, pointing to their role in wood cell wall formation and modification. Finally, by studying transgenic plants modified in various steps of the monolignol biosynthetic pathway and by localizing the expression of various enzymes, new insight into the lignin biosynthesis in planta has been gained.Journal ArticleResearch Support, Non-U.S. Gov'tReviewinfo:eu-repo/semantics/publishe
Genetic Manipulation of Fungi by DNA-Mediated Transformation
- Author
- A Aufauvre-Brown
- A Burmester
- A Burmester
- A Herrera-Estrella
- A Hinnen
- A Hino
- A Jimenez
- A Munoz-Rivas
- A Radford
- A Reddy
- A Sivan
- A Upshall
- A Vian
- AC Ward
- AH Wright
- AJ Kingsman
- AK Bej
- AL Churchill
- AL Pilgeram
- AM Ashby
- AM Bailey
- AW Murray
- AW Smith
- B Austin
- B Austin
- B Bruckner
- B Turcq
- B Turcq
- BG Turgeon
- BG Turgeon
- BG Turgeon
- BG Turgeon
- BL Miller
- BR Oakley
- C Cantwell
- C Connelly
- C Goyon
- C Guthrie
- C Mezard
- C Roitgrund
- C Russell
- CA Specht
- CE Oakley
- CJ Ulhoa
- CL Soliday
- CM Hondel
- CM Hondel
- CM Lazarus
- CM Tang
- CP Woloshuck
- CR Mcclung
- D Armeleo
- D Beach
- D Burke
- D Cullen
- D Cullen
- D Cullen
- D Cullen
- D Gems
- D Gietz
- D Huang
- D Rozman
- D Schlesinger
- D Shortle
- DA Barnes
- DA Samac
- DB Finkelstein
- DE Barnes
- DG Panaccione
- DH Williamson
- DI Gwynne
- DJ Ballance
- DJ Ballance
- DJ Ballance
- DJ Ballance
- DJ Cove
- DK Asch
- DL Toffaletti
- DM Becker
- DM Binninger
- DM Burrows
- DM Grant
- DR Smith
- DS Allison
- DT Moir
- DT Stinchcomb
- DT Stinchcomb
- DV Renno
- DW Holden
- E Alani
- E Laing
- E Nyyssonen
- E Sanchez
- E Southern
- EA Blackmore
- EB Cambareri
- EH Blackburn
- EH Froelinger
- EI Campbell
- EJ Mullaney
- EP Benito
- ET Marek
- ET Marek
- EU Selker
- EU Selker
- F Engelenburg
- F Iborra
- F Nara
- F Whendt
- FD Smith
- FM Mellon
- FP Buxton
- FP Buxton
- FR Murray
- G Banks
- G Faugeron
- G Mohr
- G Reipen
- G Richard
- G Szalo
- GA Payne
- GD Frederick
- GD Hunter
- GG Hermanson
- GH Choi
- GH Choi
- GH Goldman
- GH Nonet
- GH Thomas
- GJ Bunkers
- GL Mcknight
- GR Banks
- GR Banks
- GS May
- H Durand
- H Durand
- H Fujimura
- H Hashimoto
- H Ito
- H Singh
- H Yamamoto
- HA Fujimura
- HC Kistler
- HC Kistler
- HC Riethman
- HD Osiewacz
- HF Tsai
- HS Judelson
- IE Mattem
- IE Mattem
- IF Connerton
- IG Jones
- IG Jones
- IL Johnstone
- IL Johnstone
- IN Roberts
- J Arnau
- J Arnau
- J Arnau
- J Arnau
- J Begueret
- J Hill
- J Hinrichs
- J Maundrell
- J Tilburn
- J Wang
- JA Hargreaves
- JA Kinsey
- JB Hicks
- JB Rasmussen
- JC Royer
- JD Beggs
- JD Boeke
- JF Hamer
- JF Peberdy
- JF Peberdy
- JH Bull
- JL Armstrong
- JL Edman
- JL Revuelta
- JM Cantoral
- JM Cregg
- JM Henson
- JM Kelly
- JN Arsdell
- JP Javerzat
- JP Woods
- JP Woods
- JR Cameron
- JR Perfect
- JS Fincham
- JS Fincham
- JS Fincham
- JS Horng
- JS Williams
- JV Paietta
- JW Bennett
- JW Kronstad
- JW Szostak
- JW Szostak
- K Esser
- K Esser
- K Gomi
- K Gomi
- K Sreekrishna
- K Struhl
- K Toyota
- K Wernars
- K Wernars
- K Wernars
- KA Parsons
- KR Folger
- KR Kaster
- KR Kaster
- L Bernier
- L Carramolino
- L Clarke
- L Giasson
- L Graaff
- L Gritz
- L Lechevanton
- L Malardier
- L Ventura
- LC Haas
- LL Stohl
- LP Tikhomirova
- LP Woudt
- LS Davidow
- M Alic
- M Alic
- M Baron
- M Baron
- M Botchan
- M Casadaban
- M Daboussi
- M Kolar
- M Lorito
- M Meselson
- M Nakajima
- M Peng
- M Peng
- M Peng
- M Perrot
- M Picard
- M Walz
- M Ward
- M Ward
- M Ward
- M Ward
- M Ward
- MA Davis
- MA Innis
- MA John
- MA Romanos
- MA Romanos
- MB Dickman
- MB Dickman
- MD Thomas
- ME Case
- ME Case
- ME Penttilla
- MG Richey
- MG Roncero
- MG Schechtman
- MH Perlin
- MJ Hynes
- MJ Hynes
- MJ Orbach
- ML Farman
- MM Yelton
- MO Byun
- MP Whitehead
- MR Kuiper
- MT Boylan
- MW Gutai
- N Glab
- N Gunge
- N Kiuchi
- NC Mishra
- NN Pandit
- NO Khanh
- NY Ho
- P Bullock
- P Durrens
- PA Lemke
- PA Lemke
- PJ Punt
- PJ Punt
- PL Bolen
- PL Skatrud
- PL Skatrud
- PL Worsham
- PW Dunne
- PW Tooley
- Q Laing
- R Bauer
- R Debuchy
- R Geisen
- R Heeswijck
- R Heeswijck
- R Marmeisse
- R Ridder
- R Rothstein
- R Smit
- RA Akins
- RA Sandeman
- RB Waring
- RD Gietz
- RG Upchurch
- RH Schiestl
- RJ Dohmen
- RJ Gouka
- RJ Rodriguez
- RJ Rothstein
- RK Beni
- RK Beni
- RL Weiss
- RM Berka
- RM Gorcom
- RM Gorcom
- RM Gorcom
- RN Cooley
- RN Cooley
- RN Cooley
- RN Crowhurst
- RO Roggenkamp
- RP Moerschell
- RP Oliver
- S Arnaise
- S Das
- S Das
- S Fotheringham
- S Jain
- S Johnston
- S Scherer
- S Yagi
- SA Leong
- SA Leong
- SA Osmani
- SE Unkles
- SE Unkles
- SJ Vollmer
- SM Bhairi
- SS Dhawale
- SY Kim
- T Berges
- T Berges
- T Christiansen
- T Goosen
- T Goosen
- T Goosen
- T Igarashi
- T Kudo
- T Randall
- T Randall
- T Som
- T Suarez
- T Takahashi
- T Tsuge
- T Tsukuda
- T Yamamoto
- TA Pfeifer
- TA Randall
- TE Shockley
- TG Burland
- TI Koshy
- TL Orr-Weaver
- TL Orr-Weaver
- TL Orr-Weaver
- TL Orr-Weaver
- TL Rohrer
- TM Picknett
- TR Rao
- TT Eckdahl
- U Stahl
- U Stahl
- UA Ochsner
- V Barrett
- V Barrett
- V Glumoff
- V Lauremann
- V Razanamparany
- V Razanamparany
- VJ Ganeva
- WA Powell
- WE Timberlake
- WJ Pavan
- WL Fangman
- XJ Chen
- Y Brygoo
- Y Couteaudier
- Y Iimura
- Y Iimura
- Y Sakai
- Y Sakai
- Y Yui
- YJ DeRuiter-Jacobs
- YP Salch
- Z Feher
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1995
- Field of study
Chemical Characterization of Hydrolyzed Protein Meal Obtained from Trout (Oncorynchus My kiss) By-products Silage
- Author
- Adler-Nissen J.
- Adler-Nissen J.
- Anderson JS Higgs DA, Beames RM, Rowshandeli M.
- Beaulieu L Thibodeau J, Bonnet C, Bryl P, Carbonneau M-E.
- Castillo M Rojas A, WinChing R.
- Chalamaiah M Dinesh Kumar B, Hemalatha R, Jyothirmayi T.
- Chalamaiah M Rao GN, Rao DG, Jyothirmayi T.
- Cheng X Tang X, Wang Q, Mao XY.
- Choi YJ Hur S, Choi BD, Konno K, Park JW.
- Di Gioia L Guilbert S.
- Diniz FM Martin AM.
- Domingos AK Saad EB, Vechiatto WWD, Wilhelm HM, Ramos LP.
- Dumas A de Lange CFM, France J, Bureau DP
- Ferraz DAL Borghesi R, Oetterer M.
- Foh MBK Amadou I, Kamara MT, Foh BM, Xia W.
- Garces Y Perea C, Valencia NF, Hoyos JL, Gomez JA.
- Gbogouri GA Linder M, Fanni J, Parmentier M.
- Gildberg A.
- Goosen NJ Wet LF, Gorgens JF.
- Guerard F Guimas L, Binet A.
- Gutierrez O Savon L, Toledo J, Llanes J.
- Kageyama T.
- Klomklao S Kishimura H, Benjakul S.
- Kristinsson HG Rasco BA.
- Lanes J Borquez A, Alcaino J, Toledo J.
- Liang Y Hultin HO.
- Llanes J Toledo J, Fernandez I, Lazo J.
- Luckstadts C.
- Malicki A Zawadzki W, Bruzewicz S, Graczyk S, Czerski A.
- Maqsood S Benjakul S.
- Mazorra MA Pacheco R, Ram�rez JC, Garcia G, Lugo ME.
- Munoz A Bucheli J, Bonilla R, Hoyos JL.
- Nakayama T Hayase F, Kato H.
- Nguyen HTM Sylla KSB, Randriamahatody Z, Donnay- Moreno C, Moreau J, Tran LT.
- Oliveira IS de Lourenco L de FH, Sousa CL, Peixoto Joele MRS, Ribeiro S da C do A.
- Oterhals A Samuelsen TA.
- Ovissipour M Rasco B, Shiroodi SG, Modanlow M, Gholami S, Nemati M.
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- Samuelsen TA Mjos SA, Oterhals A.
- Samuelsen TA Mjos SA, Oterhals A.
- Samuelsen TA Oterhals A.
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- Publication venue
- 'Indian Society for Education and Environment'
- Publication date
- Field of study
Edoxaban versus warfarin in patients with atrial fibrillation
- Author
- Abdullakutty J
- Abi-Mansour P
- Abril SB
- Accini J
- Accini M
- Acikel M
- Acikel M
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- Ahmadpour H
- Ahuad Guerrero R
- Ajioka M
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- Akihisa U
- Akilli H
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- Albert L. Waldo
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- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
Contains fulltext :
125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)
Proven and potential involvement of vitamins in interactions of plants with plant growth-promoting bacteria—an overview
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- AA Aver’yanov
- AA El-Essawy
- AG Smith
- AG Vitreschak
- AH Jenkins
- AH Osmani
- AM Baya
- B Blume
- B Drigo
- B Rodelas
- B Schippers
- BG Kang
- BJ Schie Van
- BJJ Lugtenberg
- C Barth
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- CA Roessner
- CC Delwiche
- CH McBurney
- CM Burgess
- CR Smidt
- CT Jurgenson
- CY Lee
- D Faure
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- DA Primerano
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- SA Alen’kina
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- SH Lim
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- Publication venue
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- Publication date
- Field of study
GEL ENTRAPMENT AND MICRO-ENCAPSULATION: METHODS, APPLICATIONS AND ENGINEERING PRINCIPLES
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- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- Field of study