Reaction of Cr+, Mn+, Fe+, Co+, and Ni+ with O2 and N2O. Examination of the translational energy dependence of the cross sections of endothermic reactions

Journal ArticleReactions of Cr+, Mn+, Fe+, Co+, and Ni+ with 02 and N20 to yield metal oxide ions are examined using an ion beam apparatus. Reaction cross sections a as a function of ion translational energy E are reported. With one exception, Fe+ + N20, the cross sections exhibit an energy threshold E0

Reaction of Cr + , Mn + , Fe + , Co + , and Ni + with O2 and N2O. Examination of the translational energy dependence of the cross sections of endothermic reactions

Reactions of Cr + , Mn + , Fe + , Co + , and Ni + with O2 and N2O to yield metal oxide ions are examined using an ion beam apparatus. Reaction cross sections sigma as a function of ion translational energy E are reported. With one exception, Fe + +N2O, the cross sections exhibit an energy threshold Eo. Several models are used to interpret the excitation functions for the O2 reactions and it is concluded that the classical line-of-centers form sigma alpha (1–Eo/E) is most useful. Bond energies derived in this manner are D°(CrO + ) = 3.45±0.1 eV, D°(MnO + ) = 2.48±0.1 eV, D°(FeO + ) = 3.01±0.1 eV, D°(CoO + ) = 2.76±0.1 eV, and D°(NiO + ) = 1.95±0.1 eV. Since these bond energies are all greater than D°(N2–O) = 1.7 eV, the observation of energy thresholds for the reactions with N2O are surprising. These results are explained in terms of a qualitative view of the electronic potential energy surfaces involved

Linguistics

Contains research objectives and summary of research on one research project.National Institute of Mental Health (Grant 3 P01 MH13390-08S1)National Institutes of Health (Grant 5 TOl HD00111-10)National Institute of Mental Health (Grant HD 05168-01, 02, 03)M.I.T. Sloan Fund for Basic ResearchGrant Foundatio

Speech Communication

Contains research objectives and summary of research.National Institutes of Health (Grant 2 RO1 NS04332-11)National Institutes of Health (Grant 5 RO1 NS04332-11)U. S. Navy Office of Naval Research (Contract ONR N00014-67-A-0204-0069

Vision Screening in Children Aged 6 Months to 5 Years: Evidence Report and Systematic Review for the US Preventive Services Task Force

Importance: Preschool vision screening could allow detection and treatment of vision abnormalities during a critical developmental stage, preserving function and quality of life. Objective: To review the evidence on screening for and treatment of amblyopia, its risk factors, and refractive error in children aged 6 months to 5 years to inform the US Preventive Services Task Force. Data Sources: MEDLINE, Cochrane Library, CINAHL, and trial registries through June 2016; references; and experts, with surveillance of the literature through June 7, 2017. Study Selection: English-language randomized clinical trials (RCTs) or prospective cohort studies that evaluated screening, studies evaluating test accuracy, RCTs of treatment vs inactive controls, and cohort studies or case-control studies assessing harms. Data Extraction and Synthesis: Dual review of abstracts, full-text articles, and study quality; qualitative synthesis of findings. Studies were not quantitatively pooled because of clinical and methodological heterogeneity. Main Outcomes and Measures: Visual acuity, amblyopia, school performance, functioning, quality of life, test accuracy, testability, and harms. Results: Forty studies were included (N = 34 709); 34 evaluated test accuracy. No RCTs compared screening with no screening, and no studies evaluated school performance, function, or quality of life. Studies directly assessing earlier or more intensive screening were limited by high attrition. Positive likelihood ratios were between 5 and 10 for amblyopia risk factors or nonamblyogenic refractive error in most studies of test accuracy and were greater than 10 in most studies evaluating combinations of clinical tests. Inability to cooperate may limit use of some tests in children younger than 3 years. Studies with low prevalence (75%). Among children with amblyopia risk factors (eg, strabismus or anisometropia), patching improved visual acuity of the amblyopic eye by a mean of less than 1 line on a standard chart after 5 to 12 weeks for children pretreated with glasses (2 RCTs, 240 participants); more children treated with patching than with no patching experienced improvement of at least 2 lines (45% vs 21%; P = .003; 1 RCT, 180 participants). Patching plus glasses improved visual acuity by about 1 line after 1 year (0.11 logMAR [95% CI, 0.05-0.17]) for children not pretreated with glasses (1 RCT, 177 participants). Glasses alone improved visual acuity by less than 1 line after 1 year (0.08 logMAR [95% CI, 0.02-0.15], 1 RCT, 177 participants). Conclusions and Relevance: Studies directly evaluating the effectiveness of screening were limited and do not establish whether vision screening in preschool children is better than no screening. Indirect evidence supports the utility of multiple screening tests for identifying preschool children at higher risk for vision problems and the effectiveness of some treatments for improving visual acuity outcomes

Management of diarrhea in patients with HER2-positive breast cancer treated with neratinib: A case series and summary of the literature

INTRODUCTION: Neratinib and neratinib-based combinations have demonstrated efficacy for treatment of human epidermal growth factor receptor 2-positive (HER2+) early-stage and metastatic breast cancers. However, diarrhea has been reported as a common adverse event leading to neratinib discontinuation. Results from the CONTROL trial suggest that proactive diarrhea management with antidiarrheal prophylaxis or dose escalation of neratinib from a lower starting dose to the full FDA-approved dose of 240 mg/day can reduce the incidence, duration, and severity of neratinib-associated diarrhea in patients with early-stage breast cancer. Dose escalation has been included in the FDA-approved label for both early-stage and metastatic HER2+ breast cancer since June 2021. CASE SERIES: This series of five cases details real-world clinical implementation of strategies for management of neratinib-induced diarrhea in patients with early-stage and metastatic HER2+ breast cancer, including a patient with a pre-existing gastrointestinal disorder. MANAGEMENT AND OUTCOME: In four of five cases, diarrhea was managed with neratinib dose escalation, and antidiarrheal prophylaxis with loperamide plus colestipol was used in the remaining case. Management of diarrhea allowed all patients to remain on therapy. DISCUSSION: This case series shows that neratinib-associated diarrhea can be managed effectively with neratinib dose escalation from a lower initial starting dose and/or prophylactic antidiarrheal medications in a real-world clinical setting. The findings highlight the importance of patient-provider communication in proactive management of adverse events. Widespread implementation of the strategies described here may improve adherence and thereby clinical outcomes for patients with HER2+ breast cancer treated with neratinib

Does shade improve light interception efficiency? A comparison among seedlings from shade-tolerant and -intolerant temperate deciduous tree species

• Here, we tested two hypotheses: shading increases light interception efficiency (LIE) of broadleaved tree seedlings, and shade-tolerant species exhibit larger LIEs than do shade-intolerant ones. The impact of seedling size was taken into account to detect potential size-independent effects on LIE. LIE was defined as the ratio of mean light intercepted by leaves to light intercepted by a horizontal surface of equal area. • Seedlings from five species differing in shade tolerance (Acer saccharum, Betula alleghaniensis, A. pseudoplatanus, B. pendula, Fagus sylvatica) were grown under neutral shading nets providing 36, 16 and 4% of external irradiance. Seedlings (1- and 2-year-old) were three-dimensionally digitized, allowing calculation of LIE. • Shading induced dramatic reduction in total leaf area, which was lowest in shade-tolerant species in all irradiance regimes. Irradiance reduced LIE through increasing leaf overlap with increasing leaf area. There was very little evidence of significant size-independent plasticity of LIE. • No relationship was found between the known shade tolerance of species and LIE at equivalent size and irradiance

Milky Way potentials in CDM and MOND. Is the Large Magellanic Cloud on a bound orbit?

We compute the Milky Way potential in different cold dark matter (CDM) based models, and compare these with the modified Newtonian dynamics (MOND) framework. We calculate the axis ratio of the potential in various models, and find that isopotentials are less spherical in MOND than in CDM potentials. As an application of these models, we predict the escape velocity as a function of the position in the Galaxy. This could be useful in comparing with future data from planned or already-underway kinematic surveys (RAVE, SDSS, SEGUE, SIM, GAIA or the hypervelocity stars survey). In addition, the predicted escape velocity is compared with the recently measured high proper motion velocity of the Large Magellanic Cloud (LMC). To bind the LMC to the Galaxy in a MOND model, while still being compatible with the RAVE-measured local escape speed at the Sun's position, we show that an external field modulus of less than $0.03 a_0$ is needed.Comment: Accepted for publication in MNRAS, 13 pages, 7 figures, 3 table

Reconciling MOND and dark matter?

Observations of galaxies suggest a one-to-one analytic relation between the inferred gravity of dark matter at any radius and the enclosed baryonic mass, a relation summarized by Milgrom's law of modified Newtonian dynamics (MOND). However, present-day covariant versions of MOND usually require some additional fields contributing to the geometry, as well as an additional hot dark matter component to explain cluster dynamics and cosmology. Here, we envisage a slightly more mundane explanation, suggesting that dark matter does exist but is the source of MOND-like phenomenology in galaxies. We assume a canonical action for dark matter, but also add an interaction term between baryonic matter, gravity, and dark matter, such that standard matter effectively obeys the MOND field equation in galaxies. We show that even the simplest realization of the framework leads to a model which reproduces some phenomenological predictions of cold dark matter (CDM) and MOND at those scales where these are most successful. We also devise a more general form of the interaction term, introducing the medium density as a new order parameter. This allows for new physical effects which should be amenable to observational tests in the near future. Hence, this very general framework, which can be furthermore related to a generalized scalar-tensor theory, opens the way to a possible unification of the successes of CDM and MOND at different scales.Comment: 9 page