Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency

Coinfections are common in natural populations, and the literature suggests that helminth coinfection readily affects how the immune system manages malaria. For example, type 1–dependent control of malaria parasitemia might be impaired by the type 2 milieu of preexisting helminth infection. Alternatively, immunomodulatory effects of helminths might affect the likelihood of malarial immunopathology. Using rodent models of lymphatic filariasis (Litomosoides sigmodontis) and noncerebral malaria (clone AS Plasmodium chabaudi chabaudi), we quantified disease severity, parasitemia, and polyclonal splenic immune responses in BALB/c mice. We found that coinfected mice, particularly those that did not have microfilaremia (Mf), had more severe anemia and loss of body mass than did mice with malaria alone. Even when controlling for parasitemia, malaria was most severe in Mf coinfected mice, and this was associated with increased interferon-g responsiveness. Thus, in Mf mice, filariasis upset a delicate immunological balance in malaria infection and exacerbated malaria-induced immunopathology. Helminth infections are prevalent throughout tropical regions where malaria is transmitted [1–5]. Interactions among infections commonly alter disease severity [6, 7], and malaria-helminth coinfection can either exac

Prospects for the Standard Model Higgs Boson Search in the LEP 2000 Run

A study has been performed of the discovery and exclusion potential of LEP expected in 2000 for the Higgs bosonpredicted by the Standard Model. The tradeoff factors betweenincreasing the luminosity at $\sqrt{s}=204$ GeV and reduced integrated luminosity at $\sqrt{s}=206$ GeVwere studied. It was shown that only in case some evidencefor a signal is observed it might be worth to increase the integratedluminosity at the lower center-of-mass energy, otherwise,LEP should aim at the highest possible center-of-mass energy.The ultimate expected exclusion limit (at the 95\%\ confidence level)of LEP (with $\sqrt{s}=206$ GeV) is estimated to be $m_H\sim$114 GeV

‘We are all working toward one goal. We want people to become well’: A visual exploration of what promotes successful collaboration between community mental health workers and healers in Ghana

The practices of traditional and faith-based healers in low- and middle-income countries in Africa and elsewhere have come under intense scrutiny in recent years owing to allegations of human rights abuses. To mitigate these, there have been calls to develop collaborations between healers and formal health services to optimise available mental health interventions in poorly resourced contexts. For various reasons, attempts to establish such partnerships in a sustainable manner in different countries have not always been successful. In this article, we present findings from the Together for Mental Health visual research project to showcase examples of healer–health worker collaborations in Ghana that have been largely successful and discuss the barriers and facilitators to establishing these partnerships. Data reported in this article were collected using visual ethnography and filmed individual interviews with eight community mental health workers, six traditional and faith-based healers and two local philanthropists in the Bono East Region. The findings suggest that successful collaborations were built through mutually respectful interpersonal relationships, support from the health system and access to community resources. Although these facilitated collaboration, resource constraints, distrust and ethical dilemmas had to be overcome to build stronger partnerships. These findings highlight the importance of dedicated institutional and logistic support for ensuring the successful integration of the different health systems in pluralistic settings

Dense loops, supersymmetry, and Goldstone phases in two dimensions

Loop models in two dimensions can be related to O(N) models. The low-temperature dense-loops phase of such a model, or of its reformulation using a supergroup as symmetry, can have a Goldstone broken-symmetry phase for N<2. We argue that this phase is generic for -2< N <2 when crossings of loops are allowed, and distinct from the model of non-crossing dense loops first studied by Nienhuis [Phys. Rev. Lett. 49, 1062 (1982)]. Our arguments are supported by our numerical results, and by a lattice model solved exactly by Martins et al. [Phys. Rev. Lett. 81, 504 (1998)].Comment: RevTeX, 5 pages, 3 postscript figure

Inferring the neutron star equation of state from binary inspiral waveforms

The properties of neutron star matter above nuclear density are not precisely known. Gravitational waves emitted from binary neutron stars during their late stages of inspiral and merger contain imprints of the neutron-star equation of state. Measuring departures from the point-particle limit of the late inspiral waveform allows one to measure properties of the equation of state via gravitational wave observations. This and a companion talk by J. S. Read reports a comparison of numerical waveforms from simulations of inspiraling neutron-star binaries, computed for equations of state with varying stiffness. We calculate the signal strength of the difference between waveforms for various commissioned and proposed interferometric gravitational wave detectors and show that observations at frequencies around 1 kHz will be able to measure a compactness parameter and constrain the possible neutron-star equations of state.Comment: Talk given at the 12th Marcel Grossman Meeting, Paris, France, 12-18 Jul 200

Spin-Peierls states of quantum antiferromagnets on the CaV4O9Ca V_4 O_9 lattice

We discuss the quantum paramagnetic phases of Heisenberg antiferromagnets on the 1/5-depleted square lattice found in $Ca V_4 O_9$. The possible phases of the quantum dimer model on this lattice are obtained by a mapping to a quantum-mechanical height model. In addition to the ``decoupled'' phases found earlier, we find a possible intermediate spin-Peierls phase with spontaneously-broken lattice symmetry. Experimental signatures of the different quantum paramagnetic phases are discussed.Comment: 9 pages; 2 eps figure

Non-abelian statistics of half-quantum vortices in p-wave superconductors

Excitation spectrum of a half-quantum vortex in a p-wave superconductor contains a zero-energy Majorana fermion. This results in a degeneracy of the ground state of the system of several vortices. From the properties of the solutions to Bogoliubov-de-Gennes equations in the vortex core we derive the non-abelian statistics of vortices identical to that for the Moore-Read (Pfaffian) quantum Hall state.Comment: 5 pages, 3 figures, REVTeX, epsf. Reference adde