Spitzer Observations of Gamma-Ray Burst Host Galaxies: A Unique Window into High Redshift Chemical Evolution and Star-formation

We present deep Spitzer 3.6 micron observations of three z~5 GRB host galaxies. Our observations reveal that z~5 GRB hosts are a factor of 3 less luminous than the median rest-frame V-band luminosity of spectroscopically confirmed z~5 galaxies in the GOODS fields and the UDF. The strong connection between GRBs and massive star formation implies that not all star-forming galaxies at these redshifts are currently being accounted for in deep surveys and GRBs provide a unique way to measure the contribution to the star-formation rate density from galaxies at the faint end of the galaxy luminosity function. By correlating the co-moving star-formation rate density with co-moving GRB rates at lower redshifts, we estimate a lower limit to the star-formation rate density of 0.12+/-0.09 and 0.09+/-0.05 M_sun/yr/Mpc^3 at z~4.5 and z~6, respectively. Finally, we provide evidence that the average metallicity of star-forming galaxies evolves as (stellar mass density)^(0.69+/-0.17) between $z\sim5$ and $z\sim0$, probably indicative of the loss of a significant fraction of metals to the intergalactic medium, particularly in low-mass galaxies.Comment: ApJ, in pres

Using Spaced Learning Principles to Translate Knowledge into Behavior: Evidence from Investigative Interviews of Alleged Child Abuse Victims

The present study assessed the progress of 13 investigative interviewers (child protection workers and police officers) before, during, and after an intensive training program (n = 132 interviews). Training began with a 2-day workshop covering the principles of child development and child-friendly interviewing. Interviewers then submitted interviews on a bi-weekly basis to which they received written and verbal feedback over an 8-month period. A refresher session took place two months into training. Interestingly, improvements were observed only after the refresher session. Interviews conducted post-refresher training contained proportionally more open-ended questions, more child details in response to open-ended questions, and proportionally fewer closed questions than interviews conducted prior to training and in the first half of the training program. The need for ‘spaced learning’ may underlie why so many training programs have had little effect on practice

Track and capture of the orbiter with the space station remote manipulator system

Results of the first study using the real-time, man-in-the-loop Systems Engineering Simulator (SES) for track and capture of the Space Shuttle Orbiter with the space station manipulator are presented. The objectives include evaluation of the operational coordination required between the orbiter pilot and the space station manipulator operator, evaluation of the locations and required number of closed-circuit television cameras, and evaluation of the orbiter grapple fixture clearance geometry. The SES is a premium quality real-time facility with full fidelity orbiter and space station crew workstations and cockpits

Discovery Potential for New Phenomena

We examine the ability of future facilities to discover and interpret non-supersymmetric new phenomena. We first explore explicit manifestations of new physics, including extended gauge sectors, leptoquarks, exotic fermions, and technicolor models. We then take a more general approach where new physics only reveals itself through the existence of effective interactions at lower energy scales. [Summary Report of the New Phenomena Working Group. To appear in the Proceedings of the 1996 DPF/DPB Summer Study on New Directions for High Energy Physics - Snowmass96, Snowmass, CO, 25 June - 12 July 1996.]Comment: 18 pages, LaTex2

Turbulence in Three-Dimensional Simulations of Magnetopause Reconnection

We present detailed analysis of the turbulence observed in three-dimensional particle-in-cell simulations of magnetic reconnection at the magnetopause. The parameters are representative of an electron diffusion region encounter of the Magnetospheric Multiscale (MMS) mission. The turbulence is found to develop around both the magnetic X line and separatrices, is electromagnetic in nature, is characterized by a wave vector $k$ given by $k\rho_e\sim(m_eT_e/m_iT_i)^{0.25}$ with $\rho_e$ the electron Larmor radius, and appears to have the ion pressure gradient as its source of free energy. Taken together, these results suggest the instability is a variant of the lower hybrid drift instability. The turbulence produces electric field fluctuations in the out-of-plane direction (the direction of the reconnection electric field) with an amplitude of around $\pm 10$~mV/m, which is much greater than the reconnection electric field of around $0.1$~mV/m. Such large values of the out-of-plane electric field have been identified in the MMS data. The turbulence in the simulations controls the scale lengths of the density profile and current layers in asymmetric reconnection, driving them closer to $\sqrt{\rho_e\rho_i}$ than the $\rho_e$ or $d_e$ scalings seen in 2-D reconnection simulations, and produces significant anomalous resistivity and viscosity in the electron diffusion region.Comment: 11 pages, 10 figure

Reflections On Contributing To “Big Discoveries” About The Fly Clock: Our Fortunate Paths As Post-Docs With 2017 Nobel Laureates Jeff Hall, Michael Rosbash, And Mike Young

In the early 1980s Jeff Hall and Michael Rosbash at Brandeis University and Mike Young at Rockefeller University set out to isolate the period (per) gene, which was recovered in a revolutionary genetic screen by Ron Konopka and Seymour Benzer for mutants that altered circadian behavioral rhythms. Over the next 15 years the Hall, Rosbash and Young labs made a series of groundbreaking discoveries that defined the molecular timekeeping mechanism and formed the basis for them being awarded the 2017 Nobel Prize in Physiology or Medicine. Here the authors recount their experiences as post-docs in the Hall, Rosbash and Young labs from the mid-1980s to the mid-1990s, and provide a perspective of how basic research conducted on a simple model system during that era profoundly influenced the direction of the clocks field and established novel approaches that are now standard operating procedure for studying complex behavior

Burden of podoconiosis in poor rural communities in Guliso woreda, western Ethiopia

Background. Podoconiosis is an environmental lymphoedema affecting people living and working barefoot on irritant red clay soil. Podoconiosis is relatively well described in southern Ethiopia, but remains neglected in other parts of the Ethiopian highlands. This study aimed to assess the burden of podoconiosis in rural communities in western Ethiopia. Methodology/Principal Findings. A cross-sectional study was conducted in Gulliso woreda (district), west Ethiopia. A household survey in the 26 rural kebeles (villages) of this district was conducted to identify podoconiosis patients and to measure disease prevalence. A more detailed study was done in six randomly selected kebeles to describe clinical features of the disease, patients’ experiences of foot hygiene, and shoe wearing practice. 1,935 cases of podoconiosis were registered, giving a prevalence of 2.8%. The prevalence was higher in those aged 15 – 64 years (5.2%) and in females than males (prevalence ratio 2.6:1). 90.3% of patients were in the 15 – 64 year age group. In the detailed study, 335 cases were interviewed and their feet assessed. The majority of patients were farmers, uneducated, and poor. Two-third of patients developed the disease before the age of thirty. Almost all patients (97.0%) had experienced adenolymphangitis (ALA - red, hot legs, swollen and painful groin) at least once during the previous year. Patients experienced an average of 5.5 ALA episodes annually, each of average 4.4 days, thus 24 working days were lost annually. The incidence of ALA in podoconiosis patients was higher than that reported for filariasis in other countries. Shoe wearing was limited mainly due to financial problems. Conclusions. We have documented high podoconiosis prevalence, frequent adenolymphangitis and high disease-related morbidity in west Ethiopia. Interventions must be developed to prevent, treat and control podoconiosis, one of the core neglected tropical diseases in Ethiopia

The Effects of Turbulence on Three-Dimensional Magnetic Reconnection at the Magnetopause

Two- and three-dimensional particle-in-cell simulations of a recent encounter of the Magnetospheric Multiscale Mission (MMS) with an electron diffusion region at the magnetopause are presented. While the two-dimensional simulation is laminar, turbulence develops at both the x-line and along the magnetic separatrices in the three-dimensional simulation. The turbulence is strong enough to make the magnetic field around the reconnection island chaotic and produces both anomalous resistivity and anomalous viscosity. Each contribute significantly to breaking the frozen-in condition in the electron diffusion region. A surprise is that the crescent-shaped features in velocity space seen both in MMS observations and in two-dimensional simulations survive, even in the turbulent environment of the three-dimensional system. This suggests that MMS's measurements of crescent distributions do not exclude the possibility that turbulence plays an important role in magnetopause reconnection.Comment: Revised version accepted by GR

Ultrasound-guided trans-rectal high-intensity focused ultrasound (HIFU) for advanced cervical cancer ablation is feasible: a case report.

High-intensity focused ultrasound (HIFU) is an ablative treatment undergoing assessment for the treatment of benign and malignant disease. We describe the first reported intracavitary HIFU ablation for recurrent, unresectable and symptomatic cervical cancer.A 38 year old woman receiving palliative chemotherapy for metastatic cervical adenocarcinoma was offered ablative treatment from an intracavitary trans-rectal HIFU device (Sonablate® 500). Pre-treatment symptoms included vaginal bleeding and discharge that were sufficient to impede her quality of life. No peri-procedural adverse events occurred. Symptoms resolved completely immediately post-procedure, reappeared at 7 days, increasing to pre-procedural levels by day 30.This first time experience of intracavitary cervical HIFU suggests that it is feasible for palliation of advanced cervical cancer, with no early evidence of unexpected toxicity. Ethical approval had also been granted for the use of per-vaginal access if appropriate. This route, alone or in combination with the rectal route, may provide increased accessibility in future patients with a redesigned device more suited to trans-vaginal ablations.Intracavitary HIFU is a potentially safe procedure for the treatment of cervical cancer and able to provide symptomatic improvement in the palliative setting

A smoothing algorithm using cubic spline functions

Two algorithms are presented for smoothing arbitrary sets of data. They are the explicit variable algorithm and the parametric variable algorithm. The former would be used where large gradients are not encountered because of the smaller amount of calculation required. The latter would be used if the data being smoothed were double valued or experienced large gradients. Both algorithms use a least-squares technique to obtain a cubic spline fit to the data. The advantage of the spline fit is that the first and second derivatives are continuous. This method is best used in an interactive graphics environment so that the junction values for the spline curve can be manipulated to improve the fit