El nuevo modelo de operación del Infonavit en el sexenio 2001-2006: hacia la búsqueda de un nuevo modelo de innovación gubernamental

El objeto de estudio de este trabajo de investigación es hacer un análisis para determinar si efectivamente el nuevo modelo de operación que se diseñó e implementó en el Instituto del Fondo Nacional de la Vivienda para los Trabajadores (Infonavit) en el sexenio 2001-2006 fue eficiente y si en realidad significó una transformación institucional profunda que le permitirá a esta institución estar a la altura de los retos y necesidades del sector de la vivienda del país. Se revisa la importancia y el papel que juega el Infonavit en la puesta en marcha de las políticas de desarrollo humano, social y económico del país y se describe el origen y el impulsor del nuevo modelo de operación del Infonavit y las implicaciones en sus procesos sustantivos

La humanización del “oficio de defender los Derechos Humanos” desde la práctica de las defensoras

El presente artículo analiza la problemática en torno al género y al debate sobre los principios masculinos y femeninos como fuentes de construcción de lo humano. Examina también las alianzas y oposiciones entre los diferentes feminismos y masculinidades. Finalmente expone, desde una perspectiva de género, la cuestión de la vulnerabilidad de los/as defensores de derechos humanos. La tesis principal versa sobre la posibilidad de humanizar la defensa de los derechos humanos al incorporar los principios masculinos y femeninos en la práctica del oficio

Reporte del proyecto: Planeación jurídica para prevención de riesgos de empresas tecnológicas

Documento que describe el trabajo realizado en asesoria a las empresas del Parque Tecnológico del ITESO, por cuestiones de confidencialidad se suprime la información de las empresas y se registra sin anexos.ITESO, A.C

Air Quality and Active Transportation Modes: A Spatiotemporal Concurrence Analysis in Guadalajara, Mexico

The protection of pedestrians, cyclists, and public transportation passengers from environmental pollution is a global concern. This study fills the gap in the existing knowledge of temporal exposure to air pollution in Latin American metropolises. The paper proposes a methodology addressing the relationship between two objects of study, i.e., the users of active modes of transport and air quality. This new methodology assesses the spatiotemporal concurrence of both objects with statistical analysis of large open-access databases, to promote healthy and sustainable urban mobility. The application of the empirical methodology estimated the number of users of active transportation modes exposed to poor air quality episodes in the Guadalajara metropolitan area (Mexico) in 2019. The study considered two pollutants, ozone (O3) and particulate matter (PM10), and two active modes, cycling and bus rapid transit (BRT). Spatiotemporal analyses were carried out with geographic information systems, as well as with numeric computing platforms. First, big data were used to count the number of users for each mode within the area of influence of the air quality monitoring stations. Second, the number of air pollution episodes was obtained using the air quality index proposed by the Environmental Protection Agency (USA) on an hourly basis. Third, the spatiotemporal concurrence between air quality episodes and active mode users was calculated. In particular, the air quality monitoring data from the Jalisco Atmospheric Monitoring System were compared to users of the public bicycle share system, known as MiBici, and of a bus rapid transit line, known as Mi Macro Calzada. The results showed that the number of cyclists and BRT passengers exposed to poor air quality episodes was considerable in absolute terms, that is, 208,660 users, while it was marginal when compared to the total number of users exposed to better air quality categories in the study area, who represented only 10%. To apply the results at the metropolitan scale, the spatial distribution of the air quality monitoring system should be improved, as well as the availability of data on pedestrians and conventional bus passengers

Minimum Rank and Maximum Eigenvalue Multiplicity of Symmetric Tree Sign Patterns

The set of real matrices described by a sign pattern (a square matrix whose entries are elements of {+, −, 0}) has been studied extensively. A simple graph has been associated with the set of symmetric matrices having a zero-nonzero pattern of off-diagonal entries described by the graph. In this paper, we present a unified approach to the study of the set of symmetric matrices described by a sign pattern and the set of matrices associated with a graph allowing loops, with the presence or absence of loops describing the zero-nonzero pattern of the diagonal. We call any family of matrices having a common graph a cohort. For a cohort whose graph is a tree, we provide an algorithm for the calculation of the maximum of the multiplicities of eigenvalues of any matrix in the cohort. For a symmetric tree sign pattern or tree that allows loops, this algorithm allows exact computation of maximum multiplicity and minimum rank, and can be used to obtain a symmetric integer matrix realizing minimum rank

High levels of desmosines in urine and plasma pf patients with pseudoxanthoma elasticum.

BACKGROUND: Pseudoxanthoma elasticum (PXE), a rare heritable disorder caused by mutations of the ABCC6 gene, is characterized by fragmentation and mineralization of elastic fibres. We determined the extent of degradation of elastin by measuring and comparing the amount of desmosines in plasma and urine of PXE patients, healthy carriers and normal subjects. METHODS: Using capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) we measured the amount of desmosines in the urine of 46 individuals (14 PXE patients, 17 healthy carriers and 15 controls) and in the plasma of 56 subjects (18 PXE patients, 23 healthy carriers and 15 controls). Pseudoxanthoma elasticum patients and carriers were identified by clinical, structural and molecular biology analyses. RESULTS: The urinary excretion of desmosines was two-fold higher in PXE patients than in controls (P < 0.01); the values for healthy carriers were intermediate between those of PXE patients and controls. A very similar trend between patients and their relatives was observed for plasma desmosines. There was a significant correlation between the amount of the desmosines in plasma and urine. Moreover, a positive correlation was observed between urinary desmosine content and age of the patients as well as between urinary desmosine content and severity of clinical manifestations. CONCLUSIONS: Both the urinary and plasma desmosine concentrations indicate that elastin degradation is higher in PXE patients and, to a lesser extent, in healthy carriers than in normal subjects. Data seem to indicate that the amount of elastin breakdown products correlates with the age of patients as well as with the severity of the disease

Extracutaneous ultrastructural alterations in pseudoxanthoma elasticum

Pseudoxanthoma elasticum (PXE) is caused by mutations in the ABCC6 gene, encoding for the membrane transporter MRP6, whose physiological role is still unknown. PXE is characterized by skin, eye, and cardiovascular alterations mainly due to mineralization of elastic fibers. The ultrastructural alterations of a large number of tissues obtained at autopsy from 2 PXE patients were analyzed and compared to clarify the involvement of the various organs in PXE and to identify cell types responsible for clinical manifestations. Ultrastructural alterations typical of PXE were present in all organs examined and consisted mostly of fragmentation and mineralization of a number of elastic fibers, abnormalities of collagen fibril shape and size, and, less frequently, deposition of aggregates of matrix constituents in the extracellular space. The severity of alterations was more pronounced in the organs affected by the clinical manifestations of PXE. Interestingly, veins and arteries were similarly damaged, the adventitia and the perivascular connective tissue being the most affected areas. Therefore, alterations in PXE are systemic and affect all soft connective tissues, even in the absence of specific clinical manifestations. The localization of alterations suggests that fibroblasts and/or smooth muscle cells are very likely involved in the pathogenesis of the disorder. These findings may help in the diagnosis of PXE when clinical manifestations affect internal organs