Estudio etnomatemático en la confección de muebles típicos de la vela de coro

La investigación parte de la interrogante: ¿está presente conocimiento matemático en la confección de muebles típicos de artesanía veleña? y más específicamente, ¿es posible encontrar aspectos geométricos en la fabricación de estos muebles? Teóricamente se sustentó en House, Trentacosta y Burke (citados por Shirley, 2001) quienes asumen que la diversidad cultural puede ser incorporada en la pedagogía. Metodológicamente atiende a un estudio etnomatemático (D´Ambrosio, 1990) con enfoque crítico/interpretativo, dividido en cuatro fases: marco teórico, escenario, trabajo de campo y análisis.Resultados permitieron evidenciar que artesanos muestran habilidades en construcción de muebles donde están presentes elementos geométricos: circunferencia, polígonos rectangulares, simetría, rectas paralelas y medidas de ángulos. Partiendo de ello, se diseña propuesta pedagógica que recrea la enseñanza matemática con utilidad social

Increase in Knowledge of Dental Health Using Animated Video

Dental health problems are a very important concern in child development because of the vulnerability of school-age children to dental health problems. It happens because of problems with knowledge about dental health in children. This study aims to determine the increase in dental health knowledge using animated video media for health education in elementary school students in North Mollo. This is a pre-experimental design, with a one group pre-test and post-test design research design. This design does not have a comparison group, but at least a first observation (pre-test) has been made which allows testing of changes that occur after the experiment. The sampling technique used in this study was the purposive sampling technique, and the sample size is 51 students. The results of the analysis using the Wilcoxon statistical test showed that the animated video was effective to increase knowledge about dental health with a significance value (ρ) 0.00 <(α) 0.05. Animated video media can be used as an outreach technique about maintaining dental health in elementary school-aged children

The Fe-type Nitrile Hydratase from \u3cem\u3eComamonas testosteroni\u3c/em\u3e Ni1 Does Not Require an Activator Accessory Protein for Expression in \u3cem\u3eEscherichia coli\u3c/em\u3e

We report herein the functional expression of an Fe-type nitrile hydratase (NHase) without the co-expression of an activator protein or the Escherichia coli chaperone proteins GroES/EL. Soluble protein was obtained when the α- and β-subunit genes of the Fe-type NHase Comamonas testosteroni Ni1 (CtNHase) were synthesized with optimized E. coli codon usage and co-expressed. As a control, the Fe-type NHase from Rhodococcus equi TG328–2 (ReNHase) was expressed with (ReNHase+Act) and without (ReNHase−Act) its activator protein, establishing that expression of a fully functional, metallated ReNHase enzyme requires the co-expression of its activator protein, similar to all other Fe-type NHase enzymes reported to date, whereas the CtNHase does not. The X-ray crystal structure of CtNHase was determined to 2.4 Å resolution revealing an αβ heterodimer, similar to other Fe-type NHase enzymes, except for two important differences. First, two His residues reside in the CtNHase active site that are not observed in other Fe-type NHase enzymes and second, the active site Fe(III) ion resides at the bottom of a wide solvent exposed channel. The solvent exposed active site, along with the two active site histidine residues, are hypothesized to play a role in iron incorporation in the absence of an activator protein

Climate Smart agricultural practices improve soil quality through organic carbon enrichment and lower greenhouse gas emissions in farms of bread bowl of India

Acknowledgements The authors are thankful to NEWS India-UK for providing the first author Fellowship during the study. We are also grateful to CCAFS-CIMMYT for allowing us to collect soil samples from climate smart villages of Karnal, Haryana. The help received from Kartar Singh during soil analysis, and Kapil, Rakesh, Rajinder and Anil during field survey and sample collection is gratefully acknowledged. We are grateful to two anonymous reviewers for their insightful comments which significantly improved the quality of the manuscript.Peer reviewedPostprin

EUSO science

EUSO is a mission to explore the extreme universe by the probe of Ultra High Energy Cosmic Rays (UHECRs) and UHE neutrinos. EUSO monitors a gigantic volume of atmosphere from Space and measures showers induced by UHECRs and UHE neutrinos. Scientifically, it is important to measure the energy spectrum of UHECRs well beyond GZK energy with high statistics. EUSO ensures the observation of UHECRs up to 10$^{21}$eV even in the case of GZK mechanism working, and gives us a clear picture of the existence / non-existence of the GZK effect and the behavior of the spectrum beyond GZK energy, which represents the contributions from nearby sources. The anisotropy study of UHECR arrival directions in a small scale angle above GZK energy may allow us to identify individual source, because of the limited propagation distance and the high rigidity of particles. If event clusters observed by AGASA are real, it is expected from Monte Carlo simulation that EUSO will see ~100 particles from individual brightest sources and will give us a good opportunity to test the relativity in high precision. The UHE neutrino is a unique channel to explore the universe much deeper than UHECRs. EUSO essentially can measure UHE neutrinos free from background proton showers. The number of GZK neutrino events in a EUSO three years' mission is expected to be only a few. Nevertheless, it is a definitely conceivable opportunity to begin UHE neutrino astrophysics at GZK energy

Calcium-activated potassium channels mediated blood-brain tumor barrier opening in a rat metastatic brain tumor model

BACKGROUND: The blood-brain tumor barrier (BTB) impedes the delivery of therapeutic agents to brain tumors. While adequate delivery of drugs occurs in systemic tumors, the BTB limits delivery of anti-tumor agents into brain metastases. RESULTS: In this study, we examined the function and regulation of calcium-activated potassium (K(Ca)) channels in a rat metastatic brain tumor model. We showed that intravenous infusion of NS1619, a K(Ca )channel agonist, and bradykinin selectively enhanced BTB permeability in brain tumors, but not in normal brain. Iberiotoxin, a K(Ca )channel antagonist, significantly attenuated NS1619-induced BTB permeability increase. We found K(Ca )channels and bradykinin type 2 receptors (B2R) expressed in cultured human metastatic brain tumor cells (CRL-5904, non-small cell lung cancer, metastasized to brain), human brain microvessel endothelial cells (HBMEC) and human lung cancer brain metastasis tissues. Potentiometric assays demonstrated the activity of K(Ca )channels in metastatic brain tumor cells and HBMEC. Furthermore, we detected higher expression of K(Ca )channels in the metastatic brain tumor tissue and tumor capillary endothelia as compared to normal brain tissue. Co-culture of metastatic brain tumor cells and brain microvessel endothelial cells showed an upregulation of K(Ca )channels, which may contribute to the overexpression of K(Ca )channels in tumor microvessels and selectivity of BTB opening. CONCLUSION: These findings suggest that K(Ca )channels in metastatic brain tumors may serve as an effective target for biochemical modulation of BTB permeability to enhance selective delivery of chemotherapeutic drugs to metastatic brain tumors

Designing forest biodiversity experiments : general considerations illustrated by a new large experiment in subtropical China

Funded by German Research Foundation. Grant Number: DFG FOR 891/1 and 2 National Natural Science Foundation of China. Grant Numbers: NSFC 30710103907, 30930005, 31170457 , 31210103910 Swiss National Science Foundation (SNSF) Sino-German Centre for Research Promotion in BeijingPeer reviewedPublisher PD