922 research outputs found
VIV regimes and simplified solutions by the spectral model description
The present paper discusses technical aspects of the vortex-induced vibrations (VIVs) of structures excited by the wind in the framework of the spectral model, which is applied by many codes and guidelines for civil engineering verifications. Quantitative thresholds related to Scruton number domains, where the structural response can be considered in \u201cforced vibration\u201d or \u201clock-in\u201d regime, are proposed. In this way, the type of VIV response and its evaluation can be assessed with simple calculations that use the parameters already present in codes and guidelines. An analytical solution of the original model allows straightforward evaluations inclusive of operative criteria to properly consider structural and flow conditions concerning the coefficients governing the VIV response in the spectral description, leaving out some assumptions that are commonly adopted. Extensive numerical applications, limited here to circular cylinders and including a real full-scale chimney, allow to identify the most significant parameters of the model and the criticalities connected with their choice
Autoimmune Hemolytic Anemia and Pulmonary Embolism: An Association to Consider.
Autoimmune hemolytic anemia (AIHA) is increasingly recognized as a strong risk factor for venous thrombosis. However, there are currently no guidelines on thromboembolism prevention and management during AIHA. Here, we describe the case of a patient with AIHA and pulmonary embolism and resume the current knowledge on epidemiology, risk factors, treatment, and pathophysiology of thrombosis during AIHA, as well as new therapeutic perspectives to prevent thrombus formation during AIHA
Chromosomal control of non-gliadin proteins from the 70% ethanol extract of wheat endosperm
The non-gliadin fraction of the 70% ethanol extracts of compensated nulli-tetrasomics and ditelosomics of Triticum aestivum cv. Chinese Spring has been analyzed by combined electrofocusing and electrophoresis. Seventeen of the 21 protein map components of the euploid have been ascribed to eight chromosomes: 4A, 3BS, 6BS, 7BS, 3D, 4D, 5D and 7DS.
The relationship of the different map components with other proteins previously associated with the same chromosomes is discusse
On the estimation of the bed-material transport and budget along a river segment: application to the Middle Loire River, France
Sediment load and budgets are a fundamental component of the process-based hydromorphological framework developed by the REFORM project, and are needed to accurately assess the current condition of a river, its sensitivity to change, and its likely future evolutionary trajectory. This paper presents an evaluation of three different methods for estimating both bedload sediment transport and bed-material budget within river channels, using the Middle Loire River as a case study. The first method is based on the stream power concept and does not need any hydraulic calculations. It yields estimates of the sediment transport in the same order of magnitude as measurements but poor results for the bed-material budget in terms of magnitude and tendency. For the second method, hydraulic parameters are computed using the Manning–Strickler equation (or a 1D hydraulic model for steady flow). It provides useful indicators for understanding river dynamics but does not yield significant improvements compared to the first method. The third method uses 1D numerical software for water flow and river bed evolution. It yields the most accurate results for both sediment transport and bed evolution but requires more data and overall more work to construct the model. Guidance is provided on the amount of data required, the competence needed to build the models, and the predictive capability of each of the methods
Non-Ischemic Cerebral Energy Dysfunction at the Early Brain Injury Phase following Aneurysmal Subarachnoid Hemorrhage.
The pathophysiology of early brain injury following aneurysmal subarachnoid hemorrhage (SAH) is still not completely understood.
Using brain perfusion CT (PCT) and cerebral microdialysis (CMD), we examined whether non-ischemic cerebral energy dysfunction may be a pathogenic determinant of EBI.
A total of 21 PCTs were performed (a median of 41 h from ictus onset) among a cohort of 18 comatose mechanically ventilated SAH patients (mean age 58 years, median admission WFNS score 4) who underwent CMD and brain tissue PO2 (PbtO2) monitoring. Cerebral energy dysfunction was defined as CMD episodes with lactate/pyruvate ratio (LPR) >40 and/or lactate >4 mmol/L. PCT-derived global CBF was categorized as oligemic (CBF < 28 mL/100 g/min), normal (CBF 28-65 mL/100 g/min), or hyperemic (CBF 69-85 mL/100 g/min), and was matched to CMD/PbtO2 data.
Global CBF (57 ± 14 mL/100 g/min) and PbtO2 (25 ± 9 mm Hg) were within normal ranges. Episodes with cerebral energy dysfunction (n = 103 h of CMD samples, average duration 7.4 h) were frequent (66% of CMD samples) and were associated with normal or hyperemic CBF. CMD abnormalities were more pronounced in conditions of hyperemic vs. normal CBF (LPR 54 ± 12 vs. 42 ± 7, glycerol 157 ± 76 vs. 95 ± 41 µmol/L; both p < 0.01). Elevated brain LPR correlated with higher CBF (r = 0.47, p < 0.0001).
Cerebral energy dysfunction is frequent at the early phase following poor-grade SAH and is associated with normal or hyperemic brain perfusion. Our data support the notion that mechanisms alternative to ischemia/hypoxia are implicated in the pathogenesis of early brain injury after SAH
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