29,068 research outputs found

    Strategies for Optimize Off-Lattice Aggregate Simulations

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    We review some computer algorithms for the simulation of off-lattice clusters grown from a seed, with emphasis on the diffusion-limited aggregation, ballistic aggregation and Eden models. Only those methods which can be immediately extended to distinct off-lattice aggregation processes are discussed. The computer efficiencies of the distinct algorithms are compared.Comment: 6 pages, 7 figures and 3 tables; published at Brazilian Journal of Physics 38, march, 2008 (http://www.sbfisica.org.br/bjp/files/v38_81.pdf

    Vorton Formation

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    In this paper we present the first analytic model for vorton formation. We start by deriving the microscopic string equations of motion in Witten's superconducting model, and show that in the relevant chiral limit these coincide with the ones obtained from the supersonic elastic models of Carter and Peter. We then numerically study a number of solutions of these equations of motion and thereby suggest criteria for deciding whether a given superconducting loop configuration can form a vorton. Finally, using a recently developed model for the evolution of currents in superconducting strings we conjecture, by comparison with these criteria, that string networks formed at the GUT phase transition should produce no vortons. On the other hand, a network formed at the electroweak scale can produce vortons accounting for up to 6% of the critical density. Some consequences of our results are discussed.Comment: 41 pages; color figures 3-6 not included, but available from authors. To appear in Phys. Rev.

    Multiscale model for the effects of adaptive immunity suppression on the viral therapy of cancer

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    Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection. In the present work, we propose a multiscale mathematical model to study how the immune response interferes with the viral oncolytic activity. The model assumes that cytotoxic T cells can induce apoptosis in infected cancer cells and that free viruses can be inactivated by neutralizing antibodies or cleared at a constant rate by the innate immune response. Our simulations suggest that reprogramming the immune microenvironment in tumors could substantially enhance the oncolytic virotherapy in immune-competent hosts. Viable routes to such reprogramming are either in situ virus-mediated impairing of CD8+8^+ T cells motility or blockade of B and T lymphocytes recruitment. Our theoretical results can shed light on the design of viral vectors or new protocols with neat potential impacts on the clinical practice.Comment: 14 pages, 4 figure

    Automatic speaker segmentation using multiple features and distance measures: a comparison of three approaches

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    This paper addresses the problem of unsupervised speaker change detection. Three systems based on the Bayesian Information Criterion (BIC) are tested. The first system investigates the AudioSpectrumCentroid and the AudioWaveformEnvelope features, implements a dynamic thresholding followed by a fusion scheme, and finally applies BIC. The second method is a real-time one that uses a metric-based approach employing the line spectral pairs and the BIC to validate a potential speaker change point. The third method consists of three modules. In the first module, a measure based on second-order statistics is used; in the second module, the Euclidean distance and T2 Hotelling statistic are applied; and in the third module, the BIC is utilized. The experiments are carried out on a dataset created by concatenating speakers from the TIMIT database, that is referred to as the TIMIT data set. A comparison between the performance of the three systems is made based on t-statistics

    Improvement in the management of no-till in the central-southern-Brazil.

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    The soil performs important functions for the maintenance of life. The management practices based on the conservation of soil and water in no till system may improve environmental sustainability
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