624 research outputs found
The Constrained Equal Award Rule for Bankruptcy Problems with a Priori Unions
In this paper, we provide four extensions of the constrained equal award rule for bankruptcy situations to the class of bankruptcy situations with a priori unions. We present some characterisations and relations with corresponding games. The four new extensions are illustrated by a specific application.bankruptcy;a priori unions;constrained equal award
A network-based dynamical ranking system for competitive sports
From the viewpoint of networks, a ranking system for players or teams in
sports is equivalent to a centrality measure for sports networks, whereby a
directed link represents the result of a single game. Previously proposed
network-based ranking systems are derived from static networks, i.e.,
aggregation of the results of games over time. However, the score of a player
(or team) fluctuates over time. Defeating a renowned player in the peak
performance is intuitively more rewarding than defeating the same player in
other periods. To account for this factor, we propose a dynamic variant of such
a network-based ranking system and apply it to professional men's tennis data.
We derive a set of linear online update equations for the score of each player.
The proposed ranking system predicts the outcome of the future games with a
higher accuracy than the static counterparts.Comment: 6 figure
Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases
<p>Abstract</p> <p>Background</p> <p>A symposium on the mechanisms of action of inhaled airborne particulate matter (PM), pathogenic particles and fibers such as silica and asbestos, and nanomaterials, defined as synthetic particles or fibers less than 100 nm in diameter, was held on October 27 and 28, 2005, at the Environmental Protection Agency (EPA) Conference Center in Research Triangle Park, North Carolina. The meeting was the eighth in a series of transatlantic conferences first held in Penarth, Wales, at the Medical Research Council Pneumoconiosis Unit (1979), that have fostered long-standing collaborations between researchers in the fields of mineralogy, cell and molecular biology, pathology, toxicology, and environmental/occupational health.</p> <p>Results</p> <p>The goal of this meeting, which was largely supported by a conference grant from the NHLBI, was to assemble a group of clinical and basic research scientists who presented and discussed new data on the mechanistic effects of inhaled particulates on the onset and development of morbidity and mortality in the lung and cardiovascular system. Another outcome of the meeting was the elucidation of a number of host susceptibility factors implicated in adverse health effects associated with inhaled pathogenic particulates.</p> <p>Conclusion</p> <p>New models and data presented supported the paradigm that both genetic and environmental (and occupational) factors affect disease outcomes from inhaled particulates as well as cardiopulmonary responses. These future studies are encouraged to allow the design of appropriate strategies for prevention and treatment of particulate-associated morbidity and mortality, especially in susceptible populations.</p
Exposure to diesel exhaust induces changes in EEG in human volunteers
Background: Ambient particulate matter and nanoparticles have been shown to translocate to the brain, and potentially influence the central nervous system. No data are available whether this may lead to functional changes in the brain.
Methods: We exposed 10 human volunteers to dilute diesel exhaust (DE, 300 μg/m3) as a model for ambient PM exposure and filtered air for one hour using a double blind randomized crossover design. Brain activity was monitored during and for one hour following each exposure using quantitative electroencephalography (QEEG) at 8 different sites on the scalp. The frequency spectrum of the EEG signals was used to calculate the median power frequency (MPF) and specific frequency bands of the QEEG.
Results: Our data demonstrate a significant increase in MPF in response to DE in the frontal cortex within 30 min into exposure. The increase in MPF is primarily caused by an increase in fast wave activity (β2) and continues to rise during the 1 hour post-exposure interval.
Conclusion: This study is the first to show a functional effect of DE exposure in the human brain, indicating a general cortical stress response. Further studies are required to determine whether this effect is mediated by the nanoparticles in DE and to define the precise pathways involved
Wolbachia in the flesh: symbiont intensities in germ-line and somatic tissues challenge the conventional view of Wolbachia transmission routes
Symbionts can substantially affect the evolution and ecology of their hosts. The investigation of the tissue-specific distribution of symbionts (tissue tropism) can provide important insight into host-symbiont interactions. Among other things, it can help to discern the importance of specific transmission routes and potential phenotypic effects. The intracellular bacterial symbiont Wolbachia has been described as the greatest ever panzootic, due to the wide array of arthropods that it infects. Being primarily vertically transmitted, it is expected that the transmission of Wolbachia would be enhanced by focusing infection in the reproductive tissues. In social insect hosts, this tropism would logically extend to reproductive rather than sterile castes, since the latter constitute a dead-end for vertically transmission. Here, we show that Wolbachia are not focused on reproductive tissues of eusocial insects, and that non-reproductive tissues of queens and workers of the ant Acromyrmex echinatior, harbour substantial infections. In particular, the comparatively high intensities of Wolbachia in the haemolymph, fat body, and faeces, suggest potential for horizontal transmission via parasitoids and the faecal-oral route, or a role for Wolbachia modulating the immune response of this host. It may be that somatic tissues and castes are not the evolutionary dead-end for Wolbachia that is commonly thought
Reply to comment on Cruts et al. (2008), "Exposure to diesel exhaust induces changes in EEG in human volunteers" by Valberg et al
The Constrained Equal Award Rule for Bankruptcy Problems with a Priori Unions
In this paper, we provide four extensions of the constrained equal award rule for bankruptcy situations to the class of bankruptcy situations with a priori unions. We present some characterisations and relations with corresponding games. The four new extensions are illustrated by a specific application.
EFFECT OF METHOTREXATE ALONE OR IN COMBINATION WITH SULPHASALAZINE ON THE PRODUCTION AND CIRCULATING CONCENTRATIONS OF CYTOKINES AND THEIR ANTAGONISTS. LONGITUDINAL EVALUATION IN PATIENTS WITH RHEUMATOID ARTHRITIS
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