119 research outputs found
Diffraction and trapping in circular lattices
When a single two-level atom interacts with a pair of Laguerre-Gaussian beams
with opposite helicity, this leads to an efficient exchange of angular momentum
between the light field and the atom. When the radial motion is trapped by an
additional potential, the wave function of a single localized atom can be split
into components that rotate in opposite direction. This suggests a novel scheme
for atom interferometry without mirror pulses. Also atoms in this configuration
can be bound into a circular lattice
High-pressure structural, elastic and electronic properties of the scintillator host material, KMgF_3
The high-pressure structural behaviour of the fluoroperovskite KMgF_3 is
investigated by theory and experiment. Density functional calculations were
performed within the local density approximation and the generalized gradient
approximation for exchange and correlation effects, as implemented within the
full-potential linear muffin-tin orbital method. In situ high-pressure powder
x-ray diffraction experiments were performed up to a maximum pressure of 40 GPa
using synchrotron radiation. We find that the cubic Pm\bar{3}m crystal symmetry
persists throughout the pressure range studied. The calculated ground state
properties -- the equilibrium lattice constant, bulk modulus and elastic
constants -- are in good agreement with experimental results. By analyzing the
ratio between the bulk and shear modulii, we conclude that KMgF_3 is brittle in
nature. Under ambient conditions, KMgF_3 is found to be an indirect gap
insulator with the gap increasing under pressure.Comment: 4 figure
Opto-Mechanical Pattern Formation in Cold Atoms
Transverse pattern formation in an optical cavity containing a cloud of cold
two-level atoms is discussed. We show that density modulation becomes the
dominant mechanism as the atomic temperature is reduced. Indeed, for low but
achievable temperatures the internal degrees of freedom of the atoms can be
neglected, and the system is well described by treating them as mobile
dielectric particles. A linear stability analysis predicts the instability
threshold and the spatial scale of the emergent pattern. Numerical simulations
in one and two transverse dimensions confirm the instability and predict
honeycomb and hexagonal density structures, respectively, for the blue and red
detuned cases.Comment: submitted to Physical Review Letter
Coherent Control of Atomic Beam Diffraction by Standing Light
Quantum interference is shown to deliver a means of regulating the
diffraction pattern of a thermal atomic beam interacting with two standing wave
electric fields. Parameters have been identified to enhance the diffraction
probability of one momentum component over the others, with specific
application to Rb atoms.Comment: 5 figure
Application of the fluorescence spectroscopy for the analysis of the state of abdominal cavity organs tissues in mini-invasive surgery
At present, minimally invasive interventions become more widespread for treating hepatopancreatoduodenal area pathologies. However, new methods and approaches are necessary for obtaining more diagnostic information in real time. Several methods within the framework of "optical biopsy" concept are considered. The features and areas of application of each method are reviewed to find out which of them can be used in further studies to assess the possibility of intraoperative use in minimally invasive abdominal surgery. Preliminary measurements with fluorescence spectroscopy method have been performed at excitation wavelengths 365 nm and 450 nm. Areas of interest were common bile duct, gallbladder and liver abscess. In our opinion, the obtained results can be a basis for further research and provide a deeper understanding of pathological processes of abdominal cavity organs tissues
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² Π³Π΅Π½ΠΎΠ² CYP2D6 ΠΈ CYP2C9 Π½Π° ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠ°ΠΌΠ°Π΄ΠΎΠ»Π° ΠΈ ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊΠ° ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»Π° ΡΡΠΊΠΎΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΡΠΌ ΠΎΡΡΡΡΠΌ ΠΊΠ°Π»ΡΠΊΡΠ»Π΅Π·Π½ΡΠΌ Ρ ΠΎΠ»Π΅ΡΠΈΡΡΠΈΡΠΎΠΌ, ΠΏΠ΅ΡΠ΅Π½Π΅ΡΡΠΈΡ Ρ ΠΎΠ»Π΅ΡΠΈΡΡΡΠΊΡΠΎΠΌΠΈΡ
Relevance. One of the key components of the accelerated recovery protocols (ARP), in addition to minimizing the surgical approach, is an adequate postoperative analgesia. Despite this, applied postoperative analgesia combinations are not devoid of drawbacks, such as lack of effective postoperative analgesia and the presence of side effect. The use of a pharmacogenetic approach to analgesic therapy for the purpose of its personalization may increase the effectiveness and safety of the use of analgesics. In particular, the presence of an inactive CYP2D6*4 allele , in which the conversion of tramadol to its active metabolite is reduced, contributes to the insufficient efficacy of the drug. As for non-steroidal anti-inflammatory drugs, the presence of CYP2C9*2/*3 polymorphisms leads to a decrease in drug metabolism and a longer half-life, resulting in the increase of the clinical effect and the risk of adverse reactions. Thus, genotyping of patients with the determination of the presence of specific genetic factors can rationalize the postoperative analgesia.Aim of study. Evaluation of the possible association of polymorphisms of the CYP2D6 and CYP2C9 genes with the clinical efficacy of tramadol and ketorolac in relation to postoperative pain.Material and methods. This observational clinical study involved 107 patients with uncomplicated acute calculous cholecystitis who underwent videolaparoscopic cholecystectomy and perioperative treatment according to ARP. All patients underwent whole blood sampling followed by real-time polymerase chain reaction genotyping. Analgesic efficacy was assessed using a visual analog scale (VAS) and McGill Pain Questionnaire.Results. In CYP2D64* carriers pain was higher than that of wild-type carriers, according to VAS and McGill Pain Questionnaire in all investigated periods. In carriers of CYP2C9*2, the pain syndrome was lower than in carriers of the wild type at all intervals studied. In carriers of CYP2C9*3 pain was lower only after 2 and 6 hours, also according to McGill Pain Questionnaire.Conclusion. 1. The presence of the polymorphic marker CYP2D6*4 may reduce the efficacy of postoperative tramadol analgesia compared with wild type. 2. The presence of the polymorphic marker CYP2C9*2 and CYP2C9*3 may increase the efficacy of ketorolac pain relief compared to wild type.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΠ΄Π½ΠΈΠΌ ΠΈΠ· ΠΊΠ»ΡΡΠ΅Π²ΡΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² Π²ΡΠ΅Ρ
ΠΏΡΠΎΡΠΎΠΊΠΎΠ»ΠΎΠ² ΡΡΠΊΠΎΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ (ΠΠ£Π), ΠΏΠΎΠΌΠΈΠΌΠΎ ΠΌΠΈΠ½ΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π΄ΠΎΡΡΡΠΏΠ°, ΡΠ²Π»ΡΠ΅ΡΡΡ Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½Π°Ρ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ Π°Π½Π°Π»Π³Π΅Π·ΠΈΡ. ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° ΡΡΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΠΌΡΠ΅ ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΎΠ±Π΅Π·Π±ΠΎΠ»ΠΈΠ²Π°Π½ΠΈΡ Π½Π΅ Π»ΠΈΡΠ΅Π½Ρ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΎΠ², ΡΠ°ΠΊΠΈΡ
ΠΊΠ°ΠΊ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½Π°Ρ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ Π°Π½Π°Π»Π³Π΅Π·ΠΈΡ ΠΈ Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΏΠΎΠ±ΠΎΡΠ½ΡΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² ΠΎΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ². ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° ΠΊ ΠΎΠ±Π΅Π·Π±ΠΎΠ»ΠΈΠ²Π°ΡΡΠ΅ΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Ρ ΡΠ΅Π»ΡΡ Π΅Π΅ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠΎΠΆΠ΅Ρ ΠΏΠΎΠ²ΡΡΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΠΊΠΎΠ². Π ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, Π½Π°Π»ΠΈΡΠΈΠ΅ Π½Π΅Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π°Π»Π»Π΅Π»Ρ CYP2D6*4, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΌ ΡΠ½ΠΈΠΆΠ΅Π½ΠΎ ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ°ΠΌΠ°Π΄ΠΎΠ»Π° Π² Π΅Π³ΠΎ Π°ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡ, ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°. Π§ΡΠΎ ΠΊΠ°ΡΠ°Π΅ΡΡΡ Π½Π΅ΡΡΠ΅ΡΠΎΠΈΠ΄Π½ΡΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² CYP2C9*2/*3 ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° Π»Π΅ΠΊΠ°ΡΡΡΠ² ΠΈ Π±ΠΎΠ»Π΅Π΅ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌΡ ΠΏΠ΅ΡΠΈΠΎΠ΄Ρ ΠΏΠΎΠ»ΡΠ²ΡΠ²Π΅Π΄Π΅Π½ΠΈΡ, Π²ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΡΠ΅Π³ΠΎ ΠΌΠΎΠΆΠ΅Ρ ΡΡΠΈΠ»ΠΈΡΡΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ ΠΈ ΠΏΠΎΠ²ΡΡΠΈΡΡΡΡ ΡΠΈΡΠΊ Π½Π΅ΠΆΠ΅Π»Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ Π³Π΅Π½ΠΎΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ Π½Π°Π»ΠΈΡΠΈΡ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΡ
Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² ΠΌΠΎΠΆΠ΅Ρ ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ Π°Π½Π°Π»Π³Π΅Π·ΠΈΡ.Π¦Π΅Π»Ρ. ΠΡΠ΅Π½ΠΊΠ° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠΉ Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠ² Π³Π΅Π½ΠΎΠ² CYP2D6 ΠΈ CYP2C9 Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΡΡΠ°ΠΌΠ°Π΄ΠΎΠ»Π° ΠΈ ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊΠ° Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π±ΠΎΠ»ΠΈ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΡΡΠΎΠΌ ΠΎΠ±ΡΠ΅ΡΠ²Π°ΡΠΈΠΎΠ½Π½ΠΎΠΌ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΈΠ½ΠΈΠΌΠ°Π»ΠΈ ΡΡΠ°ΡΡΠΈΠ΅ 107 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΡΠΌ ΠΎΡΡΡΡΠΌ ΠΊΠ°Π»ΡΠΊΡΠ»Π΅Π·Π½ΡΠΌ Ρ
ΠΎΠ»Π΅ΡΠΈΡΡΠΈΡΠΎΠΌ, ΠΊΠΎΡΠΎΡΡΠΌ Π²ΡΠΏΠΎΠ»Π½ΡΠ»ΠΈ Π²ΠΈΠ΄Π΅ΠΎΠ»Π°ΠΏΠ°ΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΡΡ Ρ
ΠΎΠ»Π΅ΡΠΈΡΡΡΠΊΡΠΎΠΌΠΈΡ ΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΠ΅ΡΠΈΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ³Π»Π°ΡΠ½ΠΎ ΠΎΠΏΡΠΈΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΌΡ ΠΠ£Π. ΠΡΠ΅ΠΌ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΡΡ Π·Π°Π±ΠΎΡ ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠΌ Π³Π΅Π½ΠΎΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΠ΅ΠΏΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ Π² ΡΠ΅ΠΆΠΈΠΌΠ΅ ΡΠ΅Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ. ΠΠ±Π΅Π·Π±ΠΎΠ»ΠΈΠ²Π°ΡΡΠ°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»Π°ΡΡ ΠΏΡΠΈ ΠΏΠΎΠΌΠΎΡΠΈ Π²ΠΈΠ·ΡΠ°Π»ΡΠ½ΠΎΠΉ Π°Π½Π°Π»ΠΎΠ³ΠΎΠ²ΠΎΠΉ ΡΠΊΠ°Π»Ρ (ΠΠΠ¨) ΠΈ ΠΎΠΏΡΠΎΡΠ½ΠΈΠΊΠ° Π±ΠΎΠ»ΠΈ ΠΠ°ΠΊ-ΠΠΈΠ»Π»Π°.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ CYP2D6*4 Π±ΠΎΠ»Π΅Π²ΠΎΠΉ ΡΠΈΠ½Π΄ΡΠΎΠΌ Π±ΡΠ» Π²ΡΡΠ΅, ΡΠ΅ΠΌ Ρ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ Π΄ΠΈΠΊΠΎΠ³ΠΎ ΡΠΈΠΏΠ°, ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΠΠ¨ ΠΈ Π±ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΠΎΠΏΡΠΎΡΠ½ΠΈΠΊΠ° ΠΠ°ΠΊ-ΠΠΈΠ»Π»Π° Π²ΠΎ Π²ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΠ΅ ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΊΠΈ. Π£ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ CYP2C9*2 Π±ΠΎΠ»Π΅Π²ΠΎΠΉ ΡΠΈΠ½Π΄ΡΠΎΠΌ Π±ΡΠ» Π½ΠΈΠΆΠ΅, ΡΠ΅ΠΌ Ρ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ Π΄ΠΈΠΊΠΎΠ³ΠΎ ΡΠΈΠΏΠ° Π²ΠΎ Π²ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΠ΅ ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΊΠΈ. Π£ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ CYP2C9*3 Π±ΠΎΠ»Π΅Π²ΠΎΠΉ ΡΠΈΠ½Π΄ΡΠΎΠΌ Π±ΡΠ» Π½ΠΈΠΆΠ΅ ΡΠΎΠ»ΡΠΊΠΎ ΡΠ΅ΡΠ΅Π· 2 ΠΈ 6 ΡΠ°ΡΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΎΡΠ΅Π½ΠΎΡΠ½ΠΎΠΉ ΡΠΊΠ°Π»Ρ Π±ΠΎΠ»ΠΈ ΠΠ°ΠΊ-ΠΠΈΠ»Π»Π°.ΠΡΠ²ΠΎΠ΄Ρ. 1. ΠΠ°Π»ΠΈΡΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠΊΠ΅ΡΠ° CYP2D6*4 ΠΌΠΎΠΆΠ΅Ρ ΡΠ½ΠΈΠ·ΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΎΠ±Π΅Π·Π±ΠΎΠ»ΠΈΠ²Π°Π½ΠΈΡ ΡΡΠ°ΠΌΠ°Π΄ΠΎΠ»ΠΎΠΌ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π΄ΠΈΠΊΠΈΠΌ ΡΠΈΠΏΠΎΠΌ. 2. ΠΠ°Π»ΠΈΡΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠΊΠ΅ΡΠ° CYP2C9*2 ΠΈ CYP2C9*3 ΠΌΠΎΠΆΠ΅Ρ ΠΏΠΎΠ²ΡΡΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΎΠ±Π΅Π·Π±ΠΎΠ»ΠΈΠ²Π°Π½ΠΈΡ ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊΠΎΠΌ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π΄ΠΈΠΊΠΈΠΌ ΡΠΈΠΏΠΎΠΌ
Optical diagnostics of bile duct tissues state with tumor compression
The paper presents the results of in vivo experimental measurements of the endogenous fluorescence and blood perfusion in common bile duct tissues in obstructive jaundice patients during minimally invasive surgical operations. Nowadays the type of interventions become more widespread for treating hepatopancreatobiliary pathologies. An effective feedback which can be established by one or more optical diagnostic channels integrated into the standard instruments for minimally invasive manipulations would be of particular value to practical surgeons. To collect reference data, an experimental study has been conducted using a fiber optical probe with fluorescence spectroscopy and laser Doppler flowmetry channels. For every measurement, the areas of interest were different areas of common bile duct obstructed by a malignant tumor. Obtained results demonstrated significant variety registered intensities of fluorescence spectra and values of blood perfusion. Tested fiber optical endoscopic system showed sensitivity to the tissue state in the investigated area, so the two modal approach seems to be promising for further research and implementation in clinical practice
Smoking behavior, attitudes, and cessation counseling among healthcare professionals in Armenia
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