On the Optimum Long Baseline for the Next Generation Neutrino Oscillation Experiments

For high energy long baseline neutrino oscillation experiments, we propose a Figure of Merit criterion to compare the statistical quality of experiments at various oscillation distances under the condition of identical detectors and a given neutrino beam. We take into account all possible experimental errors under general consideration. In this way the Figure of Merit is closely related to the usual statistical criterion of number of sigmas. We use a realistic neutrino beam for an entry level neutrino factory and a possible superbeam from a meson source and a 100 kt detector for the calculation. We considered in detail four oscillation distances, 300 km, 700 km, 2100 km and 3000 km, in the neutrino energy range of 0.5-20 GeV for a 20 GeV entry level neutrino factory and a 50 GeV superbeam. We found that the very long baselines of 2100 km and 3000 km are preferred for the neutrino factory according to the figure of merit criterion. Our results also show that, for a neutrino factory, lower primary muon energies such as 20 GeV are preferred rather than higher ones such as 30 or 50 GeV. For the superbeam, the combination of a long baseline such as 300 km and a very long baseline like 2100 km will form a complete measurement of the oscillation parameters besides the CP phase. To measure the CP phase in a superbeam, a larger detector (a factor 3 beyond what is considered in this article) and/or a higher intensity beam will be needed to put some significant constraints on the size of the CP angle.Comment: 21 LaTeX pages, 13 PS figures, typos corrected, references adde

The CAST Time Projection Chamber

One of the three X-ray detectors of the CAST experiment searching for solar axions is a Time Projection Chamber (TPC) with a multi-wire proportional counter (MWPC) as a readout structure. Its design has been optimized to provide high sensitivity to the detection of the low intensity X-ray signal expected in the CAST experiment. A low hardware threshold of 0.8 keV is safely set during normal data taking periods, and the overall efficiency for the detection of photons coming from conversion of solar axions is 62 %. Shielding has been installed around the detector, lowering the background level to 4.10 x 10^-5 counts/cm^2/s/keV between 1 and 10 keV. During phase I of the CAST experiment the TPC has provided robust and stable operation, thus contributing with a competitive result to the overall CAST limit on axion-photon coupling and mass.Comment: 19 pages, 11 figures and images, submitted to New Journal of Physic

Investigating serum and tissue expression identified a cytokine/chemokine signature as a highly effective melanoma marker

The identification of reliable and quantitative melanoma biomarkers may help an early diagnosis and may directly affect melanoma mortality and morbidity. The aim of the present study was to identify effective biomarkers by investigating the expression of 27 cytokines/chemokines in melanoma compared to healthy controls, both in serum and in tissue samples. Serum samples were from 232 patients recruited at the IDI-IRCCS hospital. Expression was quantified by xMAP technology, on 27 cytokines/chemokines, compared to the control sera. RNA expression data of the same 27 molecules were obtained from 511 melanoma-and healthy-tissue samples, from the GENT2 database. Statistical analysis involved a 3-step approach: analysis of the single-molecules by Mann–Whitney analysis; analysis of paired-molecules by Pearson correlation; and profile analysis by the machine learning algorithm Support Vector Machine (SVM). Single-molecule analysis of serum expression identified IL-1b, IL-6, IP-10, PDGF-BB, and RANTES differently expressed in melanoma (p < 0.05). Expression of IL-8, GM-CSF, MCP-1, and TNF-α was found to be significantly correlated with Breslow thickness. Eotaxin and MCP-1 were found differentially expressed in male vs. female patients. Tissue expression analysis identified very effective marker/predictor genes, namely, IL-1Ra, IL-7, MIP-1a, and MIP-1b, with individual AUC values of 0.88, 0.86, 0.93, 0.87, respectively. SVM analysis of the tissue expression data identified the combination of these four molecules as the most effective signature to discriminate melanoma patients (AUC = 0.98). Validation, using the GEPIA2 database on an additional 1019 independent samples, fully confirmed these observations. The present study demonstrates, for the first time, that the IL-1Ra, IL-7, MIP-1a, and MIP-1b gene signature discriminates melanoma from control tissues with extremely high efficacy. We therefore propose this 4-molecule combination as an effective melanoma marker

Search for solar Kaluza-Klein axions in theories of low-scale quantum gravity

We explore the physics potential of a terrestrial detector for observing axionic Kaluza-Klein excitations coming from the Sun within the context of higher-dimensional theories of low-scale quantum gravity. In these theories, the heavier Kaluza-Klein axions are relatively short-lived and may be detected by a coincidental triggering of their two-photon decay mode. Because of the expected high multiplicity of the solar axionic excitations, we find experimental sensitivity to a fundamental Peccei-Quinn axion mass up to $10^{-2}$ eV (corresponding to an effective axion-photon coupling $g_{a\gamma \gamma} \approx 2.\times 10^{-12}$ GeV$^{-1}$) in theories with 2 extra dimensions and a fundamental quantum-gravity scale $M_{\rm F}$ of order 100 TeV, and up to $3.\times 10^{-3}$ eV (corresponding to $g_{a\gamma \gamma} \approx 6.\times 10^{-13}$ GeV$^{-1}$) in theories with 3 extra dimensions and $M_{\rm F}=1$ TeV. For comparison, based on recent data obtained from lowest level underground experiments, we derive the experimental limits: $g_{a \gamma \gamma} \stackrel{<}{{}_\sim} 2.5\times 10^{-11}$ GeV$^{-1}$ and $g_{a \gamma \gamma} \stackrel{<}{{}_\sim} 1.2\times 10^{-11}$ GeV$^{-1}$ in the aforementioned theories with 2 and 3 large compact dimensions, respectively.Comment: 19 pages, extended version, as to appear in Physical Review

Search for solar axions using Li-7

We describe a novel approach to the search for solar, near-monochromatic hadronic axions, the latter being suggested to be created in the solar core during M1 transitions between the first excited level of Li-7, at 478 keV, and the ground state. As a result of Doppler broadening, in principle these axions can be detected via resonant absorption by the same nuclide on the Earth. Excited nuclei of Li-7 are produced in the solar interior by Be-7 electron capture and thus the axions are accompanied by emission of Be-7 solar neutrinos of energy 384 keV. An experiment was made which has yielded an upper limit on hadronic axion mass of 32 keV at the 95% confidence level.Comment: revtex, 4 pages with 2 figures, title revised, minor changes, matches version to appear in Phys. Rev.

Prospects for the CERN Axion Solar Telescope Sensitivity to 14.4 keV Axions

The CERN Axion Solar Telescope (CAST) is searching for solar axions using the 9.0 T strong and 9.26 m long transverse magnetic field of a twin aperture LHC test magnet, where axions could be converted into X-rays via reverse Primakoff process. Here we explore the potential of CAST to search for 14.4 keV axions that could be emitted from the Sun in M1 nuclear transition between the first, thermally excited state, and the ground state of 57Fe nuclide. Calculations of the expected signals, with respect to the axion-photon coupling, axion-nucleon coupling and axion mass, are presented in comparison with the experimental sensitivity.Comment: 4 pages, 1 figure. Submitted to Nucl. Instr. and Meth.

CAST constraints on the axion-electron coupling

In non-hadronic axion models, which have a tree-level axion-electron interaction, the Sun produces a strong axion flux by bremsstrahlung, Compton scattering, and axio-recombination, the "BCA processes." Based on a new calculation of this flux, including for the first time axio-recombination, we derive limits on the axion-electron Yukawa coupling g_ae and axion-photon interaction strength g_ag using the CAST phase-I data (vacuum phase). For m_a < 10 meV/c2 we find g_ag x g_ae< 8.1 x 10^-23 GeV^-1 at 95% CL. We stress that a next-generation axion helioscope such as the proposed IAXO could push this sensitivity into a range beyond stellar energy-loss limits and test the hypothesis that white-dwarf cooling is dominated by axion emission

First results from the CERN Axion Solar Telescope (CAST)

Hypothetical axion-like particles with a two-photon interaction would be produced in the Sun by the Primakoff process. In a laboratory magnetic field (``axion helioscope'') they would be transformed into X-rays with energies of a few keV. Using a decommissioned LHC test magnet, CAST has been running for about 6 months during 2003. The first results from the analysis of these data are presented here. No signal above background was observed, implying an upper limit to the axion-photon coupling < 1.16 10^{-10} GeV^-1 at 95% CL for m_a <~0.02 eV. This limit is comparable to the limit from stellar energy-loss arguments and considerably more restrictive than any previous experiment in this axion mass range.Comment: 4 pages, accepted by PRL. Final version after the referees comment

Search for solar axion emission from 7Li and D(p,gamma)3He nuclear decays with the CAST gamma-ray calorimeter

We present the results of a search for a high-energy axion emission signal from 7Li (0.478 MeV) and D(p,gamma)3He (5.5 MeV) nuclear transitions using a low-background gamma-ray calorimeter during Phase I of the CAST experiment. These so-called "hadronic axions" could provide a solution to the long-standing strong-CP problem and can be emitted from the solar core from nuclear M1 transitions. This is the first such search for high-energy pseudoscalar bosons with couplings to nucleons conducted using a helioscope approach. No excess signal above background was found.Comment: 20 pages, 8 figures, final version to be published in JCA

Solar axion search with the CAST experiment

The CAST (CERN Axion Solar Telescope) experiment is searching for solar axions by their conversion into photons inside the magnet pipe of an LHC dipole. The analysis of the data recorded during the first phase of the experiment with vacuum in the magnet pipes has resulted in the most restrictive experimental limit on the coupling constant of axions to photons. In the second phase, CAST is operating with a buffer gas inside the magnet pipes in order to extent the sensitivity of the experiment to higher axion masses. We will present the first results on the $^{4}{\rm He}$ data taking as well as the system upgrades that have been operated in the last year in order to adapt the experiment for the $^{3}{\rm He}$ data taking. Expected sensitivities on the coupling constant of axions to photons will be given for the recent $^{3}{\rm He}$ run just started in March 2008.Comment: Proceedings of the ICHEP 2008 conferenc