RMD (Resource Management in Diffserv) QoS-NSLP model

This draft describes a local QoS model, denoted as Resource Management in Diffserv (RMD) QoS model, for NSIS that extends the IETF Differentiated Services (Diffserv) architecture with a scalable admission control and resource reservation concept. The specification of this QoS model includes a description of its QoS parameter information, as well as how that information should be treated or interpreted in the network

LC-PCN: The Load Control PCN Solution

There is an increased interest of simple and scalable resource provisioning solution for Diffserv network. The Load Control PCN (LC-PCN) addresses the following issues:\ud o Admission Control for real time data flows in stateless Diffserv Domains\ud o Flow Termination: Termination of flows in case of exceptional events, such as severe congestion after re-routing.\ud Admission control in a Diffserv stateless domain is a combination of:\ud o Probing, whereby a probe packet is sent along the forwarding path in a network to determine whether a flow can be admitted based upon the current congestion state of the network\ud o Admission Control based on data marking, whereby in congestion situations the data packets are marked to notify the PCN-egress-node that a congestion occurred on a particular PCN-ingress-node to PCN-egress-node path.\ud \ud The scheme provides the capability of controlling the traffic load in the network without requiring signaling or any per-flow processing in the PCN-interior-nodes. The complexity of Load Control is kept to a minimum to make implementation simple.\u

RMD-QOSM: The NSIS Quality-of-Service Model for Resource Management in Diffserv

This document describes a Next Steps in Signaling (NSIS) Quality-of- Service (QoS) Model for networks that use the Resource Management in Diffserv (RMD) concept. RMD is a technique for adding admission control and preemption function to Differentiated Services (Diffserv) networks. The RMD QoS Model allows devices external to the RMD network to signal reservation requests to Edge nodes in the RMD network. The RMD Ingress Edge nodes classify the incoming flows into traffic classes and signals resource requests for the corresponding traffic class along the data path to the Egress Edge nodes for each flow. Egress nodes reconstitute the original requests and continue forwarding them along the data path towards the final destination. In addition, RMD defines notification functions to indicate overload situations within the domain to the Edge nodes

Stem cell mechanobiology

Stem cells are undifferentiated cells that are capable of proliferation, self-maintenance and differentiation towards specific cell phenotypes. These processes are controlled by a variety of cues including physicochemical factors associated with the specific mechanical environment in which the cells reside. The control of stem cell biology through mechanical factors remains poorly understood and is the focus of the developing field of mechanobiology. This review provides an insight into the current knowledge of the role of mechanical forces in the induction of differentiation of stem cells. While the details associated with individual studies are complex and typically associated with the stem cell type studied and model system adopted, certain key themes emerge. First, the differentiation process affects the mechanical properties of the cells and of specific subcellular components. Secondly, that stem cells are able to detect and respond to alterations in the stiffness of their surrounding microenvironment via induction of lineage-specific differentiation. Finally, the application of external mechanical forces to stem cells, transduced through a variety of mechanisms, can initiate and drive differentiation processes. The coalescence of these three key concepts permit the introduction of a new theory for the maintenance of stem cells and alternatively their differentiation via the concept of a stem cell 'mechano-niche', defined as a specific combination of cell mechanical properties, extracellular matrix stiffness and external mechanical cues conducive to the maintenance of the stem cell population.<br/

Content Area Reading Preparation: Effectiveness of Four Methods of Instruction

The belief that secondary content teachers should have content reading as a course in their pre-service education is an idea that is gaining increasing acceptance. Surveys examining certification requirements show that an increasing number of states mandate a course in reading for secondary certification (Bader, 1975; Lamberg, 1978). This trend is also reflected in increased numbers of teacher training institutions that are now offering a content area reading course for their undergraduate secondary education majors, as compared to ten years ago

Electronic band structure, Fermi surface, and elastic properties of new 4.2K superconductor SrPtAs from first-principles calculations

The hexagonal phase SrPtAs (s.g. P6/mmm; #194) with a honeycomb lattice structure very recently was declared as a new low-temperature (TC ~ 4.2K) superconductor. Here by means of first-principles calculations the optimized structural parameters, electronic bands, Fermi surface, total and partial densities of states, inter-atomic bonding picture, independent elastic constants, bulk and shear moduli for SrPtAs were obtained for the first time and analyzed in comparison with the related layered superconductor SrPt2As2.Comment: 8 pages, 4 figure

Competency development for pharmacy: Adopting and adapting the Global Competency Framework

Background: With current accelerated changes in the role of the pharmacists across different sectors, evidence-based developmental tools are needed to re-define the scope of practice for early career pharmacists (foundation level) and to support pharmacists’ career development. This study aimed to develop a foundation competency framework for pharmacists in Kuwait using the International Pharmaceutical Federation (FIP) Global Competency Framework (GbCF) in an adopt and adapt approach. / Methods: A 4-phase adopt and adapt approach was followed to develop the Kuwait Foundation Competency Framework (KFCF). Phase one involved translating the FIP GbCF, into Arabic using parallel translation. Phase two utilises 2 consensus panels validation involving pharmacists from public and private sectors. Phase three involved a national survey to all registered pharmacists in Kuwait. The final phase involved focus groups with pharmacists and a consensus panel validation with key policy and decision makers in the pharmacy practice and education sectors in Kuwait. Qualitative data were thematically analysed, while quantitative data were analysed using IBM SPSS Statistics for Windows. / Results: The translation phase yielded a bilingual framework that could be utilised by pharmacists in Kuwait. The initial validation phase identified 70 behavioural statements (out of the GbCF's 100) as ‘highly relevant’ or ‘relevant’ to pharmacy practice in Kuwait. Findings from the national survey identified a list of behaviours that could be adapted in Kuwait context as well as competencies that were perceived as least relevant to Kuwait practice. The final validation phase generated a list of 98 behavioural statements to be included in the KFCF along with recommendations and an action plan to facilitate the adaptation of the framework. / Conclusion: This study presents the first bilingual (Arabic/English) pharmacy foundation competency framework that builds on the FIP GbCF. The KFCF could be utilised as a developmental tool to support pharmacists’ performance at foundation level

Event-Related Potentials during a Gambling Task in Young Adults with Attention-Deficit/Hyperactivity Disorder.

Attention-deficit hyperactivity disorder (ADHD) is characterized by deficits in executive functions and decision making during childhood and adolescence. Contradictory results exist whether altered event-related potentials (ERPs) in adults are associated with the tendency of ADHD patients toward risky behavior. Clinically diagnosed ADHD patients ( javax.xml.bind.JAXBElement@5fb8b0ff = 18) and healthy controls ( javax.xml.bind.JAXBElement@76b3b68b = 18), aged between 18 and 29 (median 22 Yo), were screened with the Conners' Adult ADHD Rating Scales and assessed by the Mini-International Neuropsychiatric Interview, adult ADHD Self-Report Scale, and by the 60-item HEXACO Personality Inventory. The characteristic personality traits of ADHD patients were the high level of impulsiveness associated with lower values of agreeableness. All participants performed a probability gambling task (PGT) with two frequencies of the feedback information of the outcome. For each trial, ERPs were triggered by the self-paced trial onset and by the gamble selection. After trial onset, N2-P3a ERP component associated with the attentional load peaked earlier in the ADHD group than in controls. An N500 component related to the feedback frequency condition after trial onset and an N400-like component after gamble selection suggest a large affective stake of the decision making and an emphasized post-decisional evaluation of the choice made by the ADHD participants. By combining ERPs, related to the emotions associated with the feedback frequency condition, and behavioral analyses during completion of PGT, this study provides new findings on the neural dynamics that differentiate controls and young ADHD adults. In the patients' group, we raise the hypothesis that the activity of frontocentral and centroparietal neural circuits drive the decision-making processes dictated by an impaired cognitive workload followed by the build-up of large emotional feelings generated by the conflict toward the outcome of the gambling choice. Our results can be used for new investigations aimed at studying the fine spatiotemporal distribution of cortical activity, and the neural circuits that underly the generation of that activity, associated with the behavioral deficits characteristic of ADHD

Band structure of (Sr3Sc2O5)Fe2As2 as a possible parent phase for new FeAs superconductors

By means of first-principles FLAPW-GGA calculations, we have investigated the electronic properties of the newly synthesized layered phase - (Sr3Sc2O5)Fe2As2. The electronic bands, density of states and Fermi surface have been evaluated. The resembling of our data for (Sr3Sc2O5)Fe2As2 with band structure pictures of known FeAs superconducting materials may be considered as the theoretical background specifying the possibility for (Sr3Sc2O5)Fe2As2 to become a parent phase for new FeAs superconductors.Comment: 10 pages, 4 figures, 3 table

Differential Anti-Proliferative and Anti-Migratory Activities of Ursolic Acid, 3-O-Acetylursolic Acid and Their Combination Treatments with Quercetin on Melanoma Cells

We evaluate how 3-acetylation modulates the in vitro activity of ursolic acid in melanoma cells alone or in combination treatments with quercetin. Anti-proliferative studies on A375 cells and adult human dermal fibroblasts included analyses on cell cycle distribution, caspase activity, phosphatidylserine translocation, cell morphology and Bax/Bcl-2 protein expression. Then, 2D and 3D migration of B16F10 cells were studied using scratch and Transwell assays, respectively. Ursolic acid and 3-O-acetylursolic acid have shown similar GI50 on A375 cells (26 µM vs. 32 µM, respectively) significantly increased both early and late apoptotic populations, activated caspases 3/7 (48–72 h), and enhanced Bax whilst attenuating Bcl-2 expression. Ursolic acid caused elevation of the sub-G1 population whilst its 3-acetyl derivative arrested cell cycle at S phase and induced strong morphological changes. Combination treatments showed that ursolic acid and quercetin act synergistically in migration assays but not against cell proliferation. In summary, 3-O-acetylursolic acid maintains the potency and overall apoptotic mechanism of the parent molecule with a more aggressive influence on the morphology of A375 melanoma cells but the 3-acetylation suppresses its anti-migratory properties. We also found that ursolic acid can act in synergy with quercetin to reduce cell migration.</jats:p