26 research outputs found

    Ferumoxytol/unspecified general anaesthesia

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    Intensive Care Risks of Pediatric Neurosurgery

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    S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity

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    Glutamate/N-methyl-d-aspartate (NMDA) receptor-mediated neurotoxicity involves cyclooxygenase (COX)-2. We demonstrate that this neurotoxicity reflects activation of COX-2 by S-nitrosylation after selective binding of neuronal nitric oxide synthase (nNOS) to COX-2. nNOS, via its PDZ domain, binds COX-2 with the generated NO S-nitrosylating and activating the enzyme. Selective disruption of nNOS—COX-2 binding prevents NMDA neurotoxicity
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