What, if Any, Are the Ethical Obligations of the U.S. Patent Office? A Closer Look at the Biological Sampling of Indigenous Groups

The patenting of biological resources collected from indigenous groups has become a controversial trend. Two U.S. patents in particular, one claiming a cell-line from a 26-year old Guayami woman and one claiming a leukemia virus from a Hagahai man in Papua New Guinea, demonstrate just how volatile this issue has become. This iBrief examines how, in light of such ethically questionable patents, the U.S. Patent Office has failed to implement any procedures to identify or curb patent applications involving indigenous peoples

Engineering a Conformant Probabilistic Planner

We present a partial-order, conformant, probabilistic planner, Probapop which competed in the blind track of the Probabilistic Planning Competition in IPC-4. We explain how we adapt distance based heuristics for use with probabilistic domains. Probapop also incorporates heuristics based on probability of success. We explain the successes and difficulties encountered during the design and implementation of Probapop

Compensating inaccurate annotations to train 3D facial landmark localisation models

In this paper we investigate the impact of inconsistency in manual annotations when they are used to train automatic models for 3D facial landmark localization. We start by showing that it is possible to objectively measure the consistency of annotations in a database, provided that it contains replicates (i.e. repeated scans from the same person). Applying such measure to the widely used FRGC database we find that manual annotations currently available are suboptimal and can strongly impair the accuracy of automatic models learnt therefrom. To address this issue, we present a simple algorithm to automatically correct a set of annotations and show that it can help to significantly improve the accuracy of the models in terms of landmark localization errors. This improvement is observed even when errors are measured with respect to the original (not corrected) annotations. However, we also show that if errors are computed against an alternative set of manual annotations with higher consistency, the accuracy of the models constructed using the corrections from the presented algorithm tends to converge to the one achieved by building the models on the alternative,more consistent set

Rotationally invariant 3D shape contexts using asymmetry patterns

This paper presents an approach to resolve the azimuth ambiguity of 3D Shape Contexts (3DSC) based on asymmetry patterns. We show that it is possible to provide rotational invariance to 3DSC at the expense of a marginal increase in computational load, outperforming previous algorithms dealing with the azimuth ambiguity. We build on a recently presented measure of approximate rotational symmetry in 2D defined as the overlapping area between a shape and rotated versions of itself to extract asymmetry patterns from a 3DSC in a variety of ways, depending on the spatial relationships that need to be highlighted or disabled. Thus, we define Asymmetry Patterns Shape Contexts (APSC) from a subset of the possible spatial relations present in the spherical grid of 3DSC; hence they can be thought of as a family of descriptors that depend on the subset that is selected. This provides great flexibility to derive different descriptors. We show that choosing the appropriate spatial patterns can considerably reduce the errors obtained with 3DSC when targeting specific types of points

Occurrence of refeeding syndrome in adults started on artificial nutrition support: prospective cohort study

This final article is available for use under the terms of the Creative Commons Attribution Non-Commercial 2.0 Licence; see http://bmjopen.bmj.comRefeeding syndrome is a potentially life-threatening condition characterised by severe intracellular electrolyte shifts, acute circulatory fluid overload and organ failure. The initial symptoms are non-specific but early clinical features are severely low-serum electrolyte concentrations of potassium, phosphate or magnesium. Risk factors for the syndrome include starvation, chronic alcoholism, anorexia nervosa and surgical interventions that require lengthy periods of fasting. The causes of the refeeding syndrome are excess or unbalanced enteral, parenteral or oral nutritional intake. Prevention of the syndrome includes identification of individuals at risk, controlled hypocaloric nutritional intake and supplementary electrolyte replacementPeer reviewedFinal Published versio

Interview with Bernard L. Whelan

Discusses attitude of Daytonians, flight training, Oscar Brindley\u27s gliders, DH-4, wind tunnel, mechanics of early planes, Aero Club of America, Canadian trainees, US Army, Smithsonian, and the OW (cabin airplane)

New Coordinates for the Amplitude Parameter Space of Continuous Gravitational Waves

The parameter space for continuous gravitational waves (GWs) can be divided into amplitude parameters (signal amplitude, inclination and polarization angles describing the orientation of the source, and an initial phase) and phase-evolution parameters. The division is useful in part because the Jaranowski-Krolak-Schutz (JKS) coordinates on the four-dimensional amplitude parameter space allow the GW signal to be written as a linear combination of four template waveforms with the JKS coordinates as coefficients. We define a new set of coordinates on the amplitude parameter space, with the same properties, which is more closely connected to the physical amplitude parameters. These naturally divide into two pairs of Cartesian-like coordinates on two-dimensional subspaces, one corresponding to left- and the other to right-circular polarization. We thus refer to these as CPF (circular polarization factored) coordinates. The corresponding two sets of polar coordinates (known as CPF-polar) can be related in a simple way to the physical parameters. We illustrate some simplifying applications for these various coordinate systems, such as: a calculation of Jacobians between various coordinate systems; an illustration of the signal coordinate singularities associated with left- and right-circular polarization, which correspond to the origins of the two two-dimensional subspaces; and an elucidation of the form of the log-likelihood ratio between hypotheses of Gaussian noise with and without a continuous GW signal. These are used to illustrate some of the prospects for approximate evaluation of a Bayesian detection statistic defined by marginalization over the physical parameter space. Additionally, in the presence of simplifying assumptions about the observing geometry, we are able to explicitly evaluate the integral for the Bayesian detection statistic, and compare it to the approximate results.Comment: REVTeX, 18 pages, 8 image files included in 7 figure

Classical T Tauri-like Outflow Activity in the Brown Dwarf Mass Regime

Over the last number of years spectroscopic studies have strongly supported the assertion that protostellar accretion and outflow activity persists to the lowest masses. In this paper we present the results of our latest investigation of brown dwarf (BD) outflow activity and report on the discovery of two new outflows. Here ISO-Oph 32 is shown to drive a blue-shifted outflow with a radial velocity of 10-20 km/s and spectro-astrometric analysis constrains the position angle of this outflow to 240 +/- 7 degrees. The BD candidate ISO-Cha1 217 is found to have a bipolar outflow bright in several key forbidden lines (radial velocity = -20 km/s, +40 km/s) and with a PA of 190-210 degrees. A striking feature of the ISO-Cha1 217 outflow is the strong asymmetry between the red and blue-shifted lobes. This asymmetry is revealed in the relative brightness of the two lobes (red-shifted lobe is brighter), the factor of two difference in radial velocity (the red-shifted lobe is faster) and the difference in the electron density (again higher in the red lobe). Such asymmetries are common in jets from low mass protostars and the observation of a marked asymmetry at such a low mass supports the idea that BD outflow activity is scaled down from low mass protostellar activity. In addition to presenting these new results, a comprehensive comparison is made between BD outflow activity and jets launched by CTTSs. In particular, the application of current methods for investigating the excitation conditions and mass loss rates in CTT jets to BD spectra is explored.Comment: Accepted by Astrophysical Journa

Grounding inside/out professional identity formation by developing wholehearted lawyers with therapeutic intent

Professional identity formation of law students ideally encompasses both development of the necessary attributes of lawyers as well as a robust philosophy to inform the character of their engagement with the justice system throughout their career. Susan Brooks’ Wholehearted Lawyering teaching principles and practices provide a sound basis for developing the complex core personal, interpersonal, and relational skills necessary for law students and lawyers to maximise constructive interactions within the legal system. Vulnerability Theory and Therapeutic Jurisprudence too, provide sound principles to guide students’ and lawyers’ purposeful engagement with the legal system, particularly to facilitate greater access to justice through resilience-building and therapeutic contributions and impacts. This article proposes an Inside/Out pedagogy that develops students’ awareness of these necessary personal and interpersonal attributes (the Inside) and that provides a framework for purposive engagement grounded in improving access to justice (the Out). This pedagogy systematically embeds both Brooks’ Wholehearted Lawyering scholarship to develop students’ core professional attributes, and principles drawn from Vulnerability Theory and Therapeutic Jurisprudence to stimulate students to crystallise their own purpose as lawyers. The article then examines the development and application of this pedagogy in an Australian legal clinic established in 2020 at Western Sydney University in New South Wales, Australia