The relationship of overweight and obesity to the motor performance of children living in South Africa

Objectives: This study aimed to determine the relationship between overweight and obesity and the motor performance of nine- to 13-year-old South African children.Design: The study used a one-way cross-sectional design based on baseline measurements.Settings and subjects: The research group comprised 280 Grade 4, 5 and 6 learners (128 boys and 152 girls) from two schools that represented a distribution of socio-economic status, race and gender.Outcome measures: Anthropometric [(body mass index (BMI) and fat percentage] and motor performance measurements (fine manual control, manual coordination, body coordination and strength and agility) were obtained by means of the Fitnessgram and the Bruininks-Oseretsky Test of Motor Proficiency-II. International age-specific cut-off points were used to classify the children’s body composition as normal weight, overweight or obese. Data were analysed by means of descriptive statistics, correlation matrices and analysis of variance, followed by a Tukey post hoc analysis.Results: The results showed that running speed and agility decreased significantly with an increase in BMI. Muscular strength also decreased significantly with a smaller practical significance, while fine manual control, manual coordination, and body coordination showed the weakest relationship to BMI. Analysis of variance showed significant relationships between BMI and running speed and agility (p-value < 0.05). These relationships were influenced differently by gender and ethnicity.Conclusion: The motor performance of young South African children was negatively influenced by overweight and obesity. Intervention strategies are recommended to reduce the consequences of overweight and obesity in the overall development of such children.S Afr Fam Pract 2012;54(5):429-43

Evaluation of Selected Aspects of the Nutrition Therapeutic Programme Offered to HIV-Positive Women of Child-Bearing Age in Western Cape Province, South Africa

Background: The Nutrition Therapeutic Programme (NTP) involves the provision of food supplements at primary health clinics (PHCs) to correct nutritional deficiencies in vulnerable groups. Although previous studies have identified problems with implementing the programme at PHCs, assessments of its efficiency have been scarce.Objective: To evaluate implementation of the NTP at PHCs that provide antiretroviral therapy.Methods: A cross-sectional, descriptive study was conducted at 17 PHCs located within 3 districts of Western Cape Province. Two target groups were chosen: 32 staff members working at the sites and 21 women of child-bearing age enrolled in the NTP. Questionnaires were used to obtain data.Results: Only 2 women (10%) lived in food-secure households; the rest were either at risk of hunger (29%) or classified as hungry (61%). Most of the women knew they had to take the supplements to improve their nutritional status, but the majority only recalled receiving basic nutritional advice, and the information was mainly given verbally. Ten of the women had shared their supplements with others, mostly with their children. The study identified lack of clearly defined NTP responsibilities at the PHCs, causing confusion amongst the staff. Although many staff members expressed problems with the NTP, only 38% of them reported having routine evaluations regarding the programme.Conclusion: Several aspects compromised the effectiveness of the NTP, including socioeconomic factors leading to clients’ non-compliance. The strategic organisation and implementation of the NTP varied between different PHCs offering antiretroviral therapy, and staff experienced difficulties with the logistics of the programme

Developing countries subcommittee of the clinical pharmacology division : The medicines utilization research in Africa (MURIA) group and IUOHAR co-organized a workshop in botswana for the promotion of rational use of medicines

The improper use of medicines is a major cause of poor therapeutic effect as well as adverse drug reactions, and has considerable financial consequences (1-4). In the present era of global economic recession, there is a need for the judicious use of resources to benefit all citizens in developing countries. Therefore, the promotion of the Rational Use of Medicines (RUM) should be a healthcare priority in African countries. Still, there is limited information available on how appropriately medicines are prescribed and used in Africa (5)

Grass Diversity and Pasture Quality Baseline Assessement in Central Madagascar

Poaceae family contributes to Madagascar’s biodiversity hotspot with 217 of 541 grass species endemic to the island, although their forage value is unknown, at least in the scientific literature. Our research aims 1) to describe the diversity of native and endemic grasses thereby recognising the role of grass species diversity in forage and ecosystem management and 2) to provide new knowledge about pasture management based on the relationship between grazing capacity and productivity within experimental pastureland plots under different fire and grazing treatments. Our study seeks to provide information to inform improvements in livestock nutrition via grazing management of natural pastures in central Madagascar, specifically around the Ankafobe, Ibity and Itremo Protected Areas. Sampling in different grassy habitats was undertaken to develop a grass checklist and overview of grass diversity across the project sites. Further, in the communal and experimental pastures standardised grass surveys were carried out to compare grazing capacity and biomass productivity in the experimental pastures. Our regional survey recorded 123 Poaceae species during the first year: including 90% native species (of which 34% were endemic) and 10% introduced species. Thirty species, all C4 and belonging to PACMAD clade, are found within established pasture grasslands. Across communal pastures the most frequently recorded species and thus most frequently grazed are Loudetia simplex, Aristida rufescens, Panicum luridum, Schizachyrium sanguineum, Hyparrhenia rufa and Aristida tenuissima – these species are predominantly associated with fire. The grazing capacity baseline, at about 0.7 to 0.8 ha/zebu/year, is similar across all experimental sites that are also characterised by having a similar climate, acidic soils with low nitrogen and phosphorus, and., Annual biomass production appears to be driven by fire frequency: at both Itremo and Ankafobe, where fire is an annual occurrence, biomass yield is 2.4-2.9t/ha whereas at Ibity, where fire frequency is fire every 3-4 years, biomass productivity is 6.9t/ha. However, it is unclear how these productivity estimates relate to forage quality; the relationship will be the subject of future work

A case control study of breast cancer risk and exposure to injectable progestogen contraceptives

No Abstract

Risk factors for coronary heart disease in the black population of the Cape Peninsula The BRISK study

A cross-sectional study of risk factors for ischaemic heart disease (IHO) in a random sample of 986 black people aged 15 - 64 years living in the Cape Peninsula revealed a population at lower risk for IHO than other South Africans. Blood pressures of 140/95 mmHg or above were found in 14,4% of males and 13,7% of females. Fifty-two per cent of males and 8,4% of females smoked, while 16,5% of males and 25,8% of females had a total cholesterol (TC) level imparting risk for developing IHO. In this population the TC level is not a good surrogate measure for low-density lipoprotein cholesterol because of the high level of high-density lipoprotein cholesterol (HOLC) found in this population. A protective HOLC/TC ratio of 20% was found in 96% of males and 96,1% of females. When considering the three major reversible IHO risk factors at a high level of risk, 30,8% of males and 12,5% of females had at least one such a risk factor. The population was frequently exposed to the media, with 80% listening to the radio every day and 55% watching television at least once a week. This suggests that a healthy lifestyle could be promoted successfully by means of these media. In addition, schools should promote a healthy lifestyle and the prevention of chronic degenerative diseases should be incorporated into the evolving primary health care services in South Africa

Reported needs of information resources, research tools, connectivity and infrastructure among African Pharmacological Scientists to improve future patient care and health.

INTRODUCTION:The potentials of Africa for growth and economic transformation through science remains challenging because of existing gaps in knowledge and infrastructure. The Africa Pharmacological Science Gateway project and the Medicines Utilization Research in Africa Group seeks to meet the research needs of African pharmacologists. This study aimed at identifying priority needs that might be met by access to information and tools through e-infrastructure. METHODS:A web-based cross-sectional study among 472 members of pharmacological societies in Africa to obtain information on their research interests and skills, available resources, needs and knowledge gaps. Descriptive analyses were done. RESULTS:A total of 118 responses from 13 countries were received, mostly from Nigeria (48.3%) and South Africa (21.3%). Respondents had wide ranges of research interests predominantly in drug utilization research.The desired resources included drug utilization research training and tools, pharmacokinetics and pharmacometrics modelling training and tools, drug-drug interaction and medicine prices resources, statistical analysis resources, access to journals, training in specific laboratory techniques, equipment and funding for research-related activities. CONCLUSIONS:Key areas of needs not currently provided by the African Pharmacological Science Gateway e-infrastructure were identified to guide further provision of resources on the e-infrastructure and potentially enhance research capacity within the continent

Principles for transformative ocean governance

With a focus on oceans, we collaborated across ecological, social and legal disciplines to respond to the United Nations call for transformation in the ‘2030 Agenda for Sustainable Development’. We developed a set of 13 principles that strategically and critically connect transformative ocean research to transformative ocean governance (complementing the UN Decade for Ocean Science). We used a rigorous, iterative and transparent consensus-building approach to define the principles, which can interact in supporting, neutral or sometimes conflicting ways. We recommend that the principles could be applied as a comprehensive set and discuss how to learn from their interactions, particularly those that reveal hidden tensions. The principles can bring and keep together partnerships for innovative ocean action. This action must respond to the many calls to reform current ocean-use practices which are based on economic growth models that have perpetuated inequities and fuelled conflict and environmental decline

Social media and COVID-19 – perceptions and public deceptions regarding colchicine, hydroxychloroquine and ivermectin and resultant lessons for future pandemics

Background: The capacity for social media to influence the consumption of re-purposed medicines to manage COVID-19 despite limited safety and efficacy data at the start of the pandemic is cause for concern. Objective: To ascertain links between social media reports and utilization for three re-purposed medicines (hydroxychloroquine (HCQ), ivermectin and colchicine) to direct future activities. Methods: A combined retrospective analysis of social media posts for these re-purposed medicines was performed in South Africa between January and June 2021 together with utilization and clinical trials data. Utilisation data from IQVIA from three different platforms included private and public markets. Clinical trials data was obtained from various databases. Chloroquine data was analysed in South Africa (HCQ was not available). Results: 77257 posts were collected across key social media platforms during the study period of which 6884 were relevant. Ivermectin had the highest number of posts (55%) followed by HCQ (44%), with limited posts for colchicine (1%). The spike in ivermectin utilisation was closely correlated with social media posts. Similarly, with chloroquine social media interest was enhanced by comments from local politicians. Sentiment analysis showed that the posts regarding the effectiveness of particularly ivermectin and HCQ were positive. Of concern is that the origin of the majority of reporters in social media (85%) was unidentifiable. Conclusion: This is the first study of its kind in South Africa providing evidence that social media is a driver of re-purposed medicine use. Healthcare professionals have a key role to provide evidence-based advice especially with unidentifiable posts