The effects of 6-hydroxydopamine on the electrical characteristics of snail neurons in long-term sensitization

The effects of the neurotoxin 6-hydroxydopamine on the formation of long-term sensitization and changes in the membrane characteristics of identified neurons were studied. Injections of the neurotoxin 6-hydroxydopamine blocked the acquisition of long-term sensitization; when neurotoxin injections were given after the formation of long-term sensitization, they had no subsequent effect on conduction parameters. At the cellular level, recording of the electrical characteristics of common snail defensive behavior command neurons (LPa3, RPa3, LPa2, and RPa2) showed that the effects of 6-hydroxydopamine consisted of a small depolarization shift in the membrane potential and a change in the action potential generation threshold. Formation of long-term sensitization after injections of 6-hydroxydopamine did not lead to further decreases in the membrane and threshold potentials of command neurons as compared with snails only given injections of 6-hydroxydopamine. The changes in electrical measures of command neurons induced by administration of the neurotoxin 6-hydroxydopamine lasted at least two weeks. © 2005 Springer Science+Business Media, Inc

Innovative Technology and Food Safety of Fruit Biopowders

A technology has been developed for biopowders production from fruit raw materials grown in the Chechen Republic. The data on vacuum microwave drying of fruit raw materials under the influence of an amplitude-modulated magnetic field with carrier frequency of 180–20 kHz and modulating frequency of 10 to 30 Hz, with magnetic induction value of 5 mt. The proposed regimes of dehydration of fruit raw materials and its subsequent grinding by gas-liquid ”explosion”, providing the possibility of successful use in dried state in production technology of soft drinks. The peculiarity is the use of ecologically clean fruits of apricots, cherry plums, cherries, pears, melons and plums grown in Shelkovsky district of the Chechen Republic as raw materials. We studied physical and chemical indicators, content of phenolic substances and organoleptic indicators of fruit raw materials, powders and beverages. We also conducted comparative assessment. Under the influence of EMB ELF vacuum microwave drying of fruits contributes to better preservation properties of raw materials and finished powders. Organoleptic evaluation showed that non-alcoholic beverages produced on the proposed technology had intense color and more pronounced flavor of sweetness and acid compared to traditional non-alcoholic beverages. The advantage of this technology is the possibility to transport components for beverage production at unregulated temperature conditions to any location that is close to the consumer and carry out the production of soft drinks there

Didactic principles of university information educational systems designing

© Authors. The attention of all parts of perspective education system should be focused on promising information technologies - a catalyst for development. Presenting information as a new resource for society development, the authors determine the didactic basis for designing effective information educational systems. Universal didactic principles for information educational systems design have been developed, the details of which for discipline and for the subject adapt them to the university organizational and pedagogical conditions. The pedagogical management functions in modern educational conditions that determine the students' motivation and stimulation initiation mechanism for mastering a knowledge new system to develop the individual's creative abilities, self-development are revealed. The paper is intended for researchers, teachers, and specialists in the field of information educational technologies

Innovative Production Technology of Drinks from Grape Cryopowders

A technology, based on the production of wine beverages from grape cryopowders in the mountain-valley zone of the Republic of Dagestan, is proposed. The data on the vacuum microwave drying of grape raw materials and subsequent grinding in a cryomill are presented. The modes of grape raw material preparation and its subsequent dehydration and cryo-grinding, which provide the possibility of successful use in the dried state in the production technology of wine drinks, are proposed. The principal feature is the use of whole grapes as a raw material, with rinds and seeds. The physical and chemical indicators, the content of phenolic substances and the organoleptic indicators of wine beverages made according to the traditional technology and the beverage made from grape cryopowders were studied. A comparative assessment of beverages was made. It is established that vacuum microwave drying conduces to better preservation of the properties of raw materials and finished products. The organoleptic assessment showed that the wine drinks developed according to the proposed technology had a more intense color and a more pronounced flavor of sweetness and sourness than traditional wine beverages. The advantage of this technology is the ability to transport grape cryopowders in unregulated temperature conditions to any point close to the consumer and carry out the production of wine beverages there

Modulation of defensive reflex conditioning in snails by serotonin

© 2015 Andrianov, Bogodvid, Deryabina, Golovchenko, Muranova, Tagirova, Vinarskaya and Gainutdinov. Highlights • Daily injection of serotonin before a training session accelerated defensive reflex conditioning in snails. Daily injection of 5-hydroxytryptophan before a training session in snails with a deficiency of serotonin induced by the “neurotoxic” analog of serotonin 5,7-dihydroxytryptamine, restored the ability of snails to learn. • After injection of the “neurotoxic” analogs of serotonin 5,6- and 5,7-dihydroxytryptamine as well as serotonin, depolarization of the membrane and decrease of the threshold potential of premotor interneurons was observed. We studied the role of serotonin in the mechanisms of learning in terrestrial snails. To produce a serotonin deficit, the “neurotoxic” analogs of serotonin, 5,6- or 5,7-dihydroxytryptamine (5,6/5,7-DHT) were used. Injection of 5,6/5,7-DHT was found to disrupt defensive reflex conditioning. Within 2 weeks of neurotoxin application, the ability to learn had recovered. Daily injection of serotonin before a training session accelerated defensive reflex conditioning and daily injections of 5-HTP in snails with a deficiency of serotonin induced by 5,7-DHT restored the snail’s ability to learn. We discovered that injections of the neurotoxins 5,6/5,7-DHT as well as serotonin, caused a decrease in the resting and threshold potentials of the premotor interneurons LPa3 and RPa3

The effects of 6-hydroxydopamine on the electrical characteristics of snail neurons in long-term sensitization

The effects of the neurotoxin 6-hydroxydopamine on the formation of long-term sensitization and changes in the membrane characteristics of identified neurons were studied. Injections of the neurotoxin 6-hydroxydopamine blocked the acquisition of long-term sensitization; when neurotoxin injections were given after the formation of long-term sensitization, they had no subsequent effect on conduction parameters. At the cellular level, recording of the electrical characteristics of common snail defensive behavior command neurons (LPa3, RPa3, LPa2, and RPa2) showed that the effects of 6-hydroxydopamine consisted of a small depolarization shift in the membrane potential and a change in the action potential generation threshold. Formation of long-term sensitization after injections of 6-hydroxydopamine did not lead to further decreases in the membrane and threshold potentials of command neurons as compared with snails only given injections of 6-hydroxydopamine. The changes in electrical measures of command neurons induced by administration of the neurotoxin 6-hydroxydopamine lasted at least two weeks. © 2005 Springer Science+Business Media, Inc

The effects of 6-hydroxydopamine on the electrical characteristics of snail neurons in long-term sensitization

The effects of the neurotoxin 6-hydroxydopamine on the formation of long-term sensitization and changes in the membrane characteristics of identified neurons were studied. Injections of the neurotoxin 6-hydroxydopamine blocked the acquisition of long-term sensitization; when neurotoxin injections were given after the formation of long-term sensitization, they had no subsequent effect on conduction parameters. At the cellular level, recording of the electrical characteristics of common snail defensive behavior command neurons (LPa3, RPa3, LPa2, and RPa2) showed that the effects of 6-hydroxydopamine consisted of a small depolarization shift in the membrane potential and a change in the action potential generation threshold. Formation of long-term sensitization after injections of 6-hydroxydopamine did not lead to further decreases in the membrane and threshold potentials of command neurons as compared with snails only given injections of 6-hydroxydopamine. The changes in electrical measures of command neurons induced by administration of the neurotoxin 6-hydroxydopamine lasted at least two weeks. © 2005 Springer Science+Business Media, Inc

The effects of 6-hydroxydopamine on the electrical characteristics of snail neurons in long-term sensitization

The effects of the neurotoxin 6-hydroxydopamine on the formation of long-term sensitization and changes in the membrane characteristics of identified neurons were studied. Injections of the neurotoxin 6-hydroxydopamine blocked the acquisition of long-term sensitization; when neurotoxin injections were given after the formation of long-term sensitization, they had no subsequent effect on conduction parameters. At the cellular level, recording of the electrical characteristics of common snail defensive behavior command neurons (LPa3, RPa3, LPa2, and RPa2) showed that the effects of 6-hydroxydopamine consisted of a small depolarization shift in the membrane potential and a change in the action potential generation threshold. Formation of long-term sensitization after injections of 6-hydroxydopamine did not lead to further decreases in the membrane and threshold potentials of command neurons as compared with snails only given injections of 6-hydroxydopamine. The changes in electrical measures of command neurons induced by administration of the neurotoxin 6-hydroxydopamine lasted at least two weeks. © 2005 Springer Science+Business Media, Inc

Didactic principles of university information educational systems designing

© Authors. The attention of all parts of perspective education system should be focused on promising information technologies - a catalyst for development. Presenting information as a new resource for society development, the authors determine the didactic basis for designing effective information educational systems. Universal didactic principles for information educational systems design have been developed, the details of which for discipline and for the subject adapt them to the university organizational and pedagogical conditions. The pedagogical management functions in modern educational conditions that determine the students' motivation and stimulation initiation mechanism for mastering a knowledge new system to develop the individual's creative abilities, self-development are revealed. The paper is intended for researchers, teachers, and specialists in the field of information educational technologies

Immune-mediated epilepsies in children

The paper reviews the current literature on immune-mediated pediatric epilepsies. It describes the clinical picture, laboratory diagnosis, and treatment of autoimmune encephalitides (limbic encephalitis and anti-NMDA-receptor antibody encephalitis), Hashimoto's encephalopathy, opsoclonus-myoclonus-syndrome, and Rasmussen's syndrome, as well as groups of acute encephalopathies with immune-mediated status epilepticus (FIRES-, DESK-, HHE- syndrome). A clinical case of Hashimoto's encephalopathy is described. Emphasis is laid on a close relationship between epilepsy and inflammation, including the development of an autoimmune process due to recurrent epileptic seizures