1,156 research outputs found
High-pressure optical studies of III-V semiconductors using the diamond anvil cell.
High pressure photoluminescence techniques have been used to investigate bulk and heterostructure properties in a number of III-V semiconductor materials systems. The results are reported in this thesis along with a description of the experimental procedures. The indirect band-gaps of a series of InxGa1-xSb/GaSb quantum-wells have been measured. The results have been extrapolated to zero indium content to give the indirect band-gaps of bulk GaSb; values quoted in the literature vary widely. We obtain results consistent with accepted values but cannot refine them due to experimental errors arising from using ruby as a pressure gauge. A development of the experimental technique is proposed which would eliminate this source of error. The low-temperature F and X band-gaps have been determined in bulk (AlxGa1-x)0.5In0.5P functions of composition; we obtain E8(T)=(1.985+0.61x)eV and E8(X)=(2.282+0.085x)eV respectively. Lower limits have been put on the position of the L minima in this system and 1% compressively strained Ga0.38,In0.62P. Band offsets have been determined in unstrained (y=0.5) and 1% (y=0.62) compressively strained Ga1-yInyP/(AlxGa1-x)0.5 In0.5P; we obtain Ev(meV)=63x+157x2 and Ec(meV)=547x-157x2 for the unstrained system and Ev(meV)=72+63x+157x2 and Ec(meV)=72+547x-157x2 for the strained system. Effects of atomic ordering on the conduction band of Ga0.5In0.5P have been investigated. An investigation of anomalous pressure coefficients in strained InxGa1-x As has been carried out. A strain-related reduction in pressure coefficients (similar to that reported for InxGa1-xAs/GaAs) is found in In0.67Ga0.33As/InGaAsP quantum-wells grown on [001] substrates, but not in InGaAs/GaAs grown on [111] substrates. Preliminary results from tensile samples show evidence of increased pressure coefficients. A new X-ray powder-diffraction technique is described for direct investigation of the elastic behaviour of strained InGaAs
Reconstruction of Random Colourings
Reconstruction problems have been studied in a number of contexts including
biology, information theory and and statistical physics. We consider the
reconstruction problem for random -colourings on the -ary tree for
large . Bhatnagar et. al. showed non-reconstruction when and reconstruction when . We tighten this result and show non-reconstruction when and reconstruction when .Comment: Added references, updated notatio
The influence of sighing respirations on infant lung function measured using multiple breath washout gas mixing techniques
There is substantial interest in studying lung function in infants, to better understand the early life origins of chronic lung diseases such as asthma. Multiple breath washout (MBW) is a technique for measuring lung function that has been adapted for use in infants. Respiratory sighs occur frequently in young infants during natural sleep, and in accordance with current MBW guidelines, result in exclusion of data from a substantial proportion of testing cycles. We assessed how sighs during MBW influenced the measurements obtained using data from 767 tests conducted on 246 infants (50% male; mean age 43 days) as part of a large cohort study. Sighs occurred in 119 (15%) tests. Sighs during the main part of the wash‐in phase (before the last 5 breaths) were not associated with differences in standard MBW measurements compared with tests without sighs. In contrast, sighs that occurred during the washout were associated with a small but discernible increase in magnitude and variability. For example, the mean lung clearance index increased by 0.36 (95% CI: 0.11–0.62) and variance increased by a multiplicative factor of 2 (95% CI: 1.6–2.5). The results suggest it is reasonable to include MBW data from testing cycles where a sigh occurs during the wash‐in phase, but not during washout, of MBW. By recovering data that would otherwise have been excluded, we estimate a boost of about 10% to the final number of acceptable tests and 6% to the number of individuals successfully tested
Changes in Youth Cigarette Use Following the Dismantling of an Antitobacco Media Campaign in Florida
We examined the association of the termination of a successful youth-targeted antitobacco media campaign ("truth") and changes in smoking rates among youths aged 12-17 years in Florida. Six telephone-based surveys were completed during the active media campaign (1998-2001), and 2 postcampaign surveys were completed in 2004 and 2006 (each n ~1,800). Prevalence of current smoking among youth observed during the campaign continued to decrease in the first postcampaign survey; however, by the second follow-up survey, youth smoking rates had increased significantly for youth aged 16 years or older. Our findings support the need for consistent antitobacco messaging to reduce the prevalence of youth smoking
Oxidation contributes to low glutathione in the airways of children with cystic fibrosis
Glutathione is an important antioxidant in the lungs but its concentration is low in the
airways of patients with cystic fibrosis. Whether this deficit occurs from an early age or how oxidative stress
contributes to lowering glutathione is unknown.
We measured glutathione, its oxidation products, myeloperoxidase, and biomarkers of hypochlorous
acid in bronchoalveolar lavage from children with cystic fibrosis and disease controls using mass
spectrometry and immunological techniques.
The concentration of glutathione was lower in bronchoalveolar lavage from children with cystic fibrosis,
whereas glutathione sulfonamide, a specific oxidation product of hypochlorous acid, was higher. Oxidised
glutathione and glutathione sulfonamide correlated with myeloperoxidase and a biomarker of hypochlorous
acid. The percentage of glutathione attached to proteins was higher in children with cystic fibrosis than
controls. Pulmonary infections in cystic fibrosis resulted in lower levels of glutathione but higher levels of
oxidised glutathione and glutathione sulfonamide in bronchoalveolar lavage.
The concentration of glutathione is low in the airways of patients with cystic fibrosis from an early age.
Increased oxidation of glutathione by hypochlorous acid and its attachment to proteins contribute to this
deficiency. Therapies targeted against myeloperoxidase may boost antioxidant defence and slow the onset
and progression of lung disease in cystic fibrosis
Respiratory impedance in healthy unsedated South African infants: Effects of maternal smoking
Background and objective: Non-invasive techniques for measuring lung mechanics in infants are needed for a better understanding of lung growth and function, and to study the effects of prenatal factors on subsequent lung growth in healthy infants. The forced oscillation technique requires minimal cooperation from the individual but has rarely been used in infants. The study aims to assess the use of the forced oscillation technique to measure the influence of antenatal exposures on respiratory mechanics in unsedated infants enrolled in a birth cohort study in Cape Town, South Africa. Methods: Healthy term infants were studied at 6–10 weeks of age using the forced oscillation technique. Respiratory impedance was measured in the frequency range 8–48 Hz via a face mask during natural sleep. Respiratory system resistance, compliance and inertance were calculated from the impedance spectra. Results: Of 177 infants tested, successful measurements were obtained in 164 (93%). Median (25–75%) values for resistance, compliance and inertance were 50.2 (39.5–60.6) cmH2O.s.L−1, 0.78 (0.61–0.99) mL.cmH2O−1 and 0.062 (0.050–0.086) cmH2O.s2.L−1, respectively. As a group, male infants had 16% higher resistance (P = 0.006) and 18% lower compliance (P = 0.02) than females. Infants whose mothers smoked during pregnancy had a 19% lower compliance than infants not exposed to tobacco smoke during pregnancy (P = 0.005). Neither maternal HIV infection nor ethnicity had a significant effect on respiratory mechanics. Conclusions: The forced oscillation technique is sensitive enough to demonstrate the effects of tobacco smoke exposure and sex in respiratory mechanics in healthy infants. This technique will facilitate assessing perinatal influences of lung function in infancy
Approximation via Correlation Decay when Strong Spatial Mixing Fails
Approximate counting via correlation decay is the core algorithmic technique used in the sharp delineation of the computational phase transition that arises in the approximation of the partition function of antiferromagnetic 2-spin models. Previous analyses of correlation-decay algorithms implicitly depended on the occurrence of strong spatial mixing. This, roughly, means that one uses worst-case analysis of the recursive procedure that creates the subinstances. In this paper, we develop a new analysis method that is more refined than the worst-case analysis. We take the shape of instances in the computation tree into consideration and we amortize against certain “bad” instances that are created as the recursion proceeds. This enables us to show correlation decay and to obtain a fully polynomial-time approximation scheme (FPTAS) even when strong spatial mixing fails. We apply our technique to the problem of approximately counting independent sets in hypergraphs with degree upper bound and with a lower bound on the arity of hyperedges. Liu and Lin gave an FPTAS for and (lack of strong spatial mixing was the obstacle preventing this algorithm from being generalized to ). Our technique gives a tight result for , showing that there is an FPTAS for and . The best previously known approximation scheme for is the Markov-chain simulation based fully polynomial-time randomized approximation scheme (FPRAS) of Bordewich, Dyer, and Karpinski, which only works for . Our technique also applies for larger values of , giving an FPTAS for . This bound is not substantially stronger than existing randomized results in the literature. Nevertheless, it gives the first deterministic approximation scheme in this regime. Moreover, unlike existing results, it leads to an FPTAS for counting dominating sets in regular graphs with sufficiently large degree. We further demonstrate that in the hypergraph independent set model, approximating the partition function is NP-hard even within the uniqueness regime. Also, approximately counting dominating sets of bounded-degree graphs (without the regularity restriction) is NP-hard
Cutoff for the Ising model on the lattice
Introduced in 1963, Glauber dynamics is one of the most practiced and
extensively studied methods for sampling the Ising model on lattices. It is
well known that at high temperatures, the time it takes this chain to mix in
on a system of size is . Whether in this regime there is
cutoff, i.e. a sharp transition in the -convergence to equilibrium, is a
fundamental open problem: If so, as conjectured by Peres, it would imply that
mixing occurs abruptly at for some fixed , thus providing
a rigorous stopping rule for this MCMC sampler. However, obtaining the precise
asymptotics of the mixing and proving cutoff can be extremely challenging even
for fairly simple Markov chains. Already for the one-dimensional Ising model,
showing cutoff is a longstanding open problem.
We settle the above by establishing cutoff and its location at the high
temperature regime of the Ising model on the lattice with periodic boundary
conditions. Our results hold for any dimension and at any temperature where
there is strong spatial mixing: For this carries all the way to the
critical temperature. Specifically, for fixed , the continuous-time
Glauber dynamics for the Ising model on with periodic boundary
conditions has cutoff at , where is
the spectral gap of the dynamics on the infinite-volume lattice. To our
knowledge, this is the first time where cutoff is shown for a Markov chain
where even understanding its stationary distribution is limited.
The proof hinges on a new technique for translating to mixing
which enables the application of log-Sobolev inequalities. The technique is
general and carries to other monotone and anti-monotone spin-systems.Comment: 34 pages, 3 figure
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