2,502 research outputs found
The significance of mixed government in southern African studies: a preliminary assessment
Paper presented at the Wits History Workshop: Democracy, Popular Precedents, Practice and Culture, 13-15 July, 199
Self-determination and the Adventure Experience: A Study of Female Adolescents
The purpose of this study was to develop an understanding of the self-determination characteristics of at-risk adolescents entering a therapeutic wilderness program and to determine the effect of the program on participants\u27 self- determination
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from Drosophila to humans. A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of T-cell lymphoblastic leukemias/lymphomas containing a t(7;9) chromosomal translocation; however, its role in oncogenesis has been unclear. Using a bone marrow reconstitution assay with cells containing retrovirally transduced TAN1 alleles, we analyzed the oncogenic potential of both nuclear and extranuclear forms of truncated TAN1 in hematopoietic cells. Although the Moloney leukemia virus long terminal repeat drives expression in most hematopoietic cell types, retroviruses encoding either form of the TAN1 protein induced clonal leukemias of exclusively immature T cell phenotypes in approximately 50% of transplanted animals. All tumors overexpressed truncated TAN1 of the size and subcellular localization predicted from the structure of the gene. These results show that TAN1 is an oncoprotein and suggest that truncation and overexpression are important determinants of transforming activity. Moreover, the murine tumors caused by TAN1 in the bone marrow transplant model are very similar to the TAN1-associated human tumors and suggest that TAN1 may be specifically oncotropic for T cells
Atypical Presentation of Mollaret’s Meningitis
Mollaret’s meningitis is mostly described in the setting of recurrent attacks of fever along with signs and symptoms of meningitis. It resolves spontaneously without any treatment and in most of the cases no causative organism is identified. Here we present an atypical case of mollaret’s meningitis in which the patient presented with headache and meningismus in the absence of fever
Does a Computer have an Arrow of Time?
In [Sch05a], it is argued that Boltzmann's intuition, that the psychological
arrow of time is necessarily aligned with the thermodynamic arrow, is correct.
Schulman gives an explicit physical mechanism for this connection, based on the
brain being representable as a computer, together with certain thermodynamic
properties of computational processes. [Haw94] presents similar, if briefer,
arguments. The purpose of this paper is to critically examine the support for
the link between thermodynamics and an arrow of time for computers. The
principal arguments put forward by Schulman and Hawking will be shown to fail.
It will be shown that any computational process that can take place in an
entropy increasing universe, can equally take place in an entropy decreasing
universe. This conclusion does not automatically imply a psychological arrow
can run counter to the thermodynamic arrow. Some alternative possible explana-
tions for the alignment of the two arrows will be briefly discussed.Comment: 31 pages, no figures, publication versio
Care of HIV-Infected Pregnant Women in Maternal–Fetal Medicine Programs
Objective: To survey the evolution over the past decade of attitudes and practices of obstetricians in maternal–fetal medicine fellowship programs regarding the management of human immunodeficiency virus (HIV)-infected pregnant women. Methods: Directors of all 65 approved maternal–fetal medicine training programs were sent questionnaires, responses to which were to reflect the consensus among members of their faculties. Programs were stratified based upon the number of HIV-infected pregnant patients cared for in the previous year. Results: Responses reflect experience with over 1000 infected pregnantwomen per year, nearly one-quarter with advanced disease. Combination antiretroviral therapy was prescribed by all respondents, universally in the 2nd and 3rd trimesters. A three-drug regimen (often containing a protease inhibitor) was used more often by those who treated at least 20 HIV-infected pregnant patients per year than by those programs seeing a lower number of patients (80 vs 59%).Despite the known and unknown risks of the use of antiretrovirals during pregnancy, only half of all responding programs report adverse events to the Antiretroviral Pregnancy Registry; reporting was more common among the institutions seeing a higher number of patients (61 vs 45%). Seventy-eight percent of higher volume programs enroll their patients in clinical studies, usually multicenter, versus 35% of lower volume programs. Conclusions: Care for HIV² pregnant women has dramatically changed over the past decade. Antiretroviral therapy is now universally prescribed by physicians involved in maternal–fetal medicine training programs. Given limited experience with these agents in the setting of pregnancy, it is essential for maternal–fetal medicine practitioners to actively report on adverse events and participate in clinical trials
Strong Approximation of Empirical Copula Processes by Gaussian Processes
We provide the strong approximation of empirical copula processes by a
Gaussian process. In addition we establish a strong approximation of the
smoothed empirical copula processes and a law of iterated logarithm
Quantum Multiplexing with the Orbital Angular Momentum of light
The orbital angular momentum, OAM, of photons offers a suitable support to
carry the quantum data of multiple users. We present two novel optical setups
that send the information of n quantum communication parties through the same
free-space optical link. Those qubits can be sent simultaneously and share
path, wavelength and polarization without interference, increasing the
communication capacity of the system. The first solution, a qubit combiner,
merges n channels into the same link, which transmits n independent photons.
The second solution, the OAM multiplexer, uses CNOT gates to transfer the
information of n optical channels to a single photon. Additional applications
of the multiplexer circuits, such as quantum arithmetic, as well as connections
to OAM sorting are discussed
An Alternative Interpretation of Statistical Mechanics
In this paper I propose an interpretation of classical statistical mechanics that centers on taking seriously the idea that probability measures represent complete states of statistical mechanical systems. I show how this leads naturally to the idea that the stochasticity of statistical mechanics is associated directly with the observables of the theory rather than with the microstates (as traditional accounts would have it). The usual assumption that microstates are representationally significant in the theory is therefore dispensable, a consequence which suggests interesting possibilities for developing non-equilibrium statistical mechanics and investigating inter-theoretic answers to the foundational questions of statistical mechanics
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