Circulating inflammatory and hemostatic biomarkers are associated with risk of myocardial infarction and coronary death, but not angina pectoris, in older men

Aims: The extent to which hemostatic and inflammatory biomarkers are related to angina pectoris as compared with myocardial infarction (MI) remains uncertain. We examined the relationship between a wide range of inflammatory and hemostatic biomarkers, including markers of activated coagulation, fibrinolysis and endothelial dysfunction and viscosity, with incident myocardial infarction (MI) or coronary heart disease (CHD) death and incident angina pectoris uncomplicated by MI or CHD death in older men. Methods: A prospective study of 3217 men aged 60-79 years with no baseline CHD (angina or MI) and who were not on warfarin, followed up for 7 years during which there were 198 MI/CHD death cases and 220 incident uncomplicated angina cases. Results: Inflammatory biomarkers [C-reactive protein (CRP), interleukin-6, fibrinogen], plasma viscosity and hemostatic biomarkers [von Willebrand factor (VWF) and fibrin D-dimer] were associated with a significant increased risk of MI/CHD death but not with uncomplicated angina even after adjustment for age and conventional risk factors. Adjustment for CRP attenuated the relationships between VWF, fibrin D-dimer and plasma viscosity with MI/CHD death. Comparisons of differing associations with risk of MI/CHD deaths and uncomplicated angina were significant for the inflammatory markers (P < 0.05) and marginally significant for fibrin D-dimer (P = 0.05). In contrast, established risk factors including blood pressure and high-density lipoprotein (HDL)-cholesterol were associated with both MI/CHD death and uncomplicated angina. Conclusion: Circulating biomarkers of inflammation and hemostasis are associated with incident MI/CHD death but not incident angina uncomplicated by MI or CHD death in older men

Interpreting Customary Rights Orders under the Foreshore and Seabed Act: The New Jurisdiction of the Maori Land Court

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Variability Pattern for Resistance to Purple Blotch (Alternaria porri ) Disease of Onions (Allium cepa L.) in North Western Nigeria

Five onion cultivars Red Creole, Kaharda, Koumassa, Sokoto local and ori were selected on the basis of diverse genetic backgrounds with respect to resistance to Alternaria porri (Ellis.) Cif. The cultivars were crossed in a complete diallel, the 25 F1s generated and their parents were evaluated in replicated yield trials at Sokoto in Sokoto State and Talata Mafara in Zamfara State, Nigeria, during the 2004/2005 and 2005/2006 dry seasons. The experiments were laid out in a randomised complete block design (RCBD) with three replications. Analysis of the variance component for the combined seasons and locations indicate that genotypic variance was greater than the environmental variance for all characters under  consideration with exception of bulb weight. Disease incidence recorded 31.20%, 30.58% and 5.42% as phenotypic, genotypic and environmental coefficients of variability. Disease severity recorded 34.96%, 32.84% and 11.00% as phenotypic, genotypic and environmental coefficients of variability. With respect to fresh bulb yield 94.90%, 93.53% and 15.78% were observed as phenotypic, genotypic and environmental coefficients of variability for the genotypes. Cured bulb yield recorded 103.47%, 102.27% and 14.96% respectively as phenotypic, genotypic and environmental coefficients of variability. Similarly 29.43%, 24.79% and 17.91% were observed for days to maturity, as phenotypic, genotypic and environmental coefficients of variability. Variability was found to exist among the genotypes for the various characters they were evaluated for.Keywords: Variability, Resistance, Purple Blotch, Disease, Onion

A Comparison of a Brain-Computer Interface and an Eye Tracker: Is There a More Appropriate Technology for Controlling a Virtual Keyboard in an ALS Patient?

The ability of people affected by amyotrophic lateral sclerosis (ALS), muscular dystrophy or spinal cord injuries to physically interact with the environment, is usually reduced. In some cases, these patients suffer from a syndrome known as locked-in syndrome (LIS), defined by the patient’s inability to make any move-ment but blinks and eye movements. Tech communication systems available for people in LIS are very limited, being those based on eye-tracking and brain-computer interface (BCI) the most useful for these patients. A comparative study between both technologies in an ALS patient is carried out: an eye tracker and a visual P300-based BCI. The purpose of the study presented in this paper is to show that the choice of the technology could depend on user´s preference. The evaluation of performance, workload and other subjective measures will allow us to determine the usability of the systems. The obtained results suggest that, even if for this patient the BCI technology is more appropriate, the technology should be always tested and adapted for each user.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Psychological, psychophysical, and ergogenic effects of music in swimming

OBJECTIVES: Existing work using dry land exercise-related activities has shown that the careful application of music can lead to a range of benefits that include enhanced affect, lower perceived exertion, greater energy efficiency, and faster time trial performances. The purpose of this study was to assess the psychological, psychophysical, and ergogenic effects of asynchronous music in swimming using a mixed-methods approach. DESIGN: A mixed-model design was employed wherein there was a within-subjects factor (two experimental conditions and a control) and a between-subjects factor (gender). The experimental component of the study was supplemented by qualitative data that were analysed using inductive content analysis. METHODS: Twenty six participants (Mage = 20.0 years, age range: 18–23 years) underwent a period of habituation with Speedo Aquabeat MP3 players prior to the experimental phase. They were then administered two experimental trials (motivational and oudeterous music at 130 bpm) and a no-music control, during which they engaged in a 200-m freestyle swimming time trial. RESULTS: Participants swam significantly faster when exposed to either music condition relative to control (p = .022, ηp2=.18). Moreover, the music conditions were associated with higher state motivation (p = .016, ηp2=.15) and more dissociative thoughts (p = .014, ηp2=.16). CONCLUSIONS: Findings supported the hypothesis that the use of asynchronous music during a high-intensity task can have an ergogenic effect; this was in the order of 2% when averaged out across the two experimental conditions. The use of music, regardless of its motivational qualities, resulted in higher self-reported motivation as well as more dissociative thoughts

Mentoring students’ intercultural learning during study abroad

Globally, study abroad programmes in the university sector have grown markedly over the last two decades, alongside the increased mobility of capital, goods, and people across the world (Block, Gray, and Holborow 2012, Duchêne and Heller 2012). The higher education sector has introduced various initiatives in order to address these ‘new times’ (New London Group 1996), including internationalised curricula with an intercultural dimension, and the option to study abroad for a component of a degree. Indeed, the opportunity to incorporate study abroad experiences into degree programmes is attractive for individuals seeking professional qualifications to work in internationally connected space

Strong Stein neighborhood bases

Let D be a smooth bounded pseudoconvex domain in C^n. We give several characterizations for the closure of D to have a strong Stein neighborhood basis in the sense that D has a defining function r such that {z\in C^n:r(z)<a} is pseudoconvex for sufficiently small a>0. We also show that this condition is invariant under proper holomorphic maps that extend smoothly to the boundary.Comment: 14 pages, fixed same references, to appear in Complex Var. Elliptic Eq

Parasitic Cape honeybee workers, Apis mellifera capensis, evade policing

Relocation of the Cape honeybee, Apis mellifera capensis, by bee-keepers from southern to northern South Africa in 1990 has caused widespread death of managed African honeybee, A. m. scutellata, colonies. Apis mellifera capensis worker bees are able to lay diploid, female eggs without mating by means of automictic thelytoky (meiosis followed by fusion of two meiotic products to restore egg diploidy), whereas workers of other honeybee subspecies are able to lay only haploid, male eggs. The A. m. capensis workers, which are parasitizing and killing A. m. scutellata colonies in northern South Africa, are the asexual offspring of a single, original worker in which the small amount of genetic variation observed is due to crossing over during meiosis (P. Kryger, personal communication). Here we elucidate two principal mechanisms underlying this parasitism. Parasitic A. m. capensis workers activate their ovaries in host colonies that have a queen present (queenright colonies), and they lay eggs that evade being killed by other workers (worker policing)—the normal fate of worker-laid eggs in colonies with a queen. This unique parasitism by workers is an instance in which a society is unable to control the selfish actions of its members