Adjunctive transdermal cannabidiol for adults with focal epilepsy: a randomized clinical trial.

Cannabidiol has shown efficacy in randomized clinical trials for drug-resistant epilepsy in specific syndromes that predominantly affect children. However, high-level evidence for the efficacy and safety of cannabidiol in the most common form of drug-resistant epilepsy in adults, focal epilepsy, is lacking. Question: What is the efficacy, safety, and tolerability of transdermally administered cannabidiol in adults with drug-resistant focal epilepsy? Findings: In a randomized, double-blind, placebo-controlled, multicenter clinical trial of 188 patients, no difference was found in seizure frequency at week 12 of the double-blind period among the placebo, 195-mg cannabidiol, and 390-mg cannabidiol treatments. The open-label extension demonstrated the long-term safety, tolerability, and acceptability of transdermal cannabidiol delivery, with a seizure reduction of at least 50% in more than half of the patients by month 6 of the trial. Meaning: Although cannabidiol did not perform significantly better than placebo in this trial, it was well tolerated and safe; future studies to assess the effect of higher doses may be warranted

Chemistry of Temperate Exoplanet Hazes from the Laboratory

International audienceLittle experimental work has been done to explore the properties of photochemical hazes formed in exoplanets, despite their role in atmospheric chemistry and their subsequent possible impact on observations. I will present results of the composition of haze particles produced from exoplanet laboratory studies in the JHU PHAZER laboratory. Post-haze production, we used very high resolution mass spectrometry to measure the chemical components of the solid particles. Many complex molecular species with general chemical formulae CwHxNyOz were detected. Molecular formulae of interest in the data include those with prebiotic implications, including amino acids, nucleobases, and simple sugars. Additionally, the experimental exoplanetary haze analogues exhibit diverse solubility characteristics, which may provide insight into the possibility of further chemical or physical alteration of photochemical hazes in exoplanet atmospheres. These laboratory particles can help us better understand chemical processes happening in exo-atmospheres and suggest a possible source of prebiotic chemistry on distant worlds

Oxygenated Planetary Hazes In Our Backyard: Triton and Carbon Monoxide

International audienc

Chemistry of Laboratory Exoplanet Hazes

International audienceI will present results of the composition of exoplanet haze particles determined from very high resolution mass spectrometry and elemental analysis. This work is part of ongoing exoplanet laboratory studies in the JHU PHAZER laboratory

Chemistry of Laboratory Exoplanet Hazes

International audienceI will present results of the composition of exoplanet haze particles determined from very high resolution mass spectrometry and elemental analysis. This work is part of ongoing exoplanet laboratory studies in the JHU PHAZER laboratory