Multiple genome-wide analyses of smoking behavior in the Framingham Heart Study

BACKGROUND: Cigarette smoking behavior may have a genetic basis. We assessed evidence for quantitative trait loci (QTLs) affecting the maximum number of cigarettes smoked per day, a trait meant to quantify this behavior, using data collected over 40 years as part of the Framingham Heart Study's original and offspring cohorts. RESULTS: Heritability was estimated to be approximately 21% using variance components (VC) methods (SOLAR), while oligogenic linkage and segregation analysis based on Bayesian Markov chain Monte Carlo (MCMC) methods (LOKI) estimated a mean of two large QTLs contributing approximately 28% and 20%, respectively, to the trait's variance. Genome-wide parametric (FASTLINK) and VC linkage analyses (SOLAR) revealed several LOD scores greater than 1.0, with peak LOD scores using both methods on chromosomes 2, 17, and 20; multi-point MCMC methods followed up on these chromosomes. The most robust linkage results were for a QTL between 65 and 84 cM on chromosome 20 with signals from multiple sex- and age-adjusted analyses including two-point LOD scores of 1.30 (parametric) and 1.07 (heritability = 0.17, VC) at 70.51 cM, a multi-point LOD score of 1.50 (heritability = 0.20, VC) at 84 cM, and an intensity ratio of 12.0 (MCMC) at 65 cM. CONCLUSION: Familial aggregation of the maximum number of cigarettes smoked per day was consistent with a genetic component to this behavior, and oligogenic segregation analyses using MCMC suggested two important QTLs. Linkage signals on chromosome 20 between 65 and 84 cM were seen using multiple analytical methods. No linkage result, however, met genome-wide statistical significance criteria, and the true relationship between these regions and smoking behavior remains unclear

Perceptions of Licensure: A Survey of Michigan Genetic Counselors

This study by the Michigan Genetic Counselor Licensure Committee is the first known published documentation of genetic counselors’ beliefs and attitudes about licensure. The response rate from genetic counselors in Michigan was 66% (41/62). Ninety‐five percent of respondents were supportive of licensure. Respondents believed licensure would legitimize genetic counseling as a distinct allied healthcare profession (97.5%), increase the public’s protection (75%), and allow genetic counselors to practice independently (67%). While 45% felt licensure would increase counselor involvement in lawsuits, this did not impact licensure support (p = 0.744). Opinions were split regarding physician supervision and ordering tests. Even though 28% favored physician supervision, there was overwhelming support for genetic counselors performing some components of genetic testing (95%) and ordering some types of genetic tests (82%) independent of a physician. Use of this survey may be helpful in other states to assess genetic counselors’ interest in licensure and for drafting legislation.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147114/1/jgc40357.pd

Family history of cancer and head and neck cancer survival

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137774/1/lary26524_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137774/2/lary26524.pd

Hadronic interaction of eta and eta-prime mesons with nucleons

Due to their short life-time, flavour-neutral mesons cannot be utilized as free secondary beams or targets, and therefore a study of their interaction with nucleons is not possible via direct scattering experiments. This interaction is, however, accessible via its influence on the energy dependence - and on the phase space distributions of the cross sections for reactions in which these mesons are produced. In case of the p p --> p p eta reaction the experimentally determined distributions of the differential cross sections close to the production threshold cannot be described by taking into account the S-wave proton-proton and proton-eta interaction only. Here we show that the angular distributions determined at the COSY-11 facility reveal some evidence for P-wave admixture in the proton-proton subsystem already at an excess energy as low as Q = 15.5 MeV. We also present that one can estimate the relative strength of the eta-nucleon and eta-prime-nucleon interactions by comparison of the eta and eta-prime production yield.Comment: 4 pages, 3 figures, Talk given at 16th International Conference on Particles and Nuclei (PANIC 02), Osaka, Japan, 30 Sep - 4 Oct 200

Experimental study of the eta-meson interaction with two-nucleons

By means of the COSY-11 detection system, using a stochastically cooled proton beam of the cooler synchrotron COSY and a hydrogen cluster target, we have performed a high statistics measurement of the pp --> pp eta reaction at an excess energy of Q = 15.5 MeV. The experiment was based on the four-momentum determination of both outgoing protons. This permits to identify pp --> pp eta events and to derive the complete kinematical information of the eta-p-p-system allowing for subsequent investigations of the eta-p interaction. The observed spectrum of the invariant mass of the proton-proton system deviates strongly from the phase-space distribution revealing the influence of the final-state-interaction among the outgoing particles or nontrivial features of the primary production mechanism.Comment: 6 pages, 4 figures, Talk presented at Meson 2002, 7th International Workshop on Meson Production, Properties and Interaction, Cracow, Poland, 24-28 May 200

Analysing power A(y) in the reaction p(pol.)p --> pp eta near threshold

A first measurement of the analysing power in the reaction p(pol)p --> pp eta near the production threshold has been performed at the internal facility COSY-11 at the COoler SYnchrotron COSY.Comment: 4 pages, 2 figures, Presented at Meson 2002: 7th International Workshop on Production, Properties and Interaction of Mesons, Cracow, Poland, 24-28 May 200

First close-to-threshold measurement of the analyzing power Ay in the reaction p(pol)p -> pp eta

At the internal facility COSY-11 a first measurement of the reaction p(pol)p -> pp eta near the production threshold has been performed. Results for the analysing power will be presented and a comparison with one meson exchange models will be discussed.Comment: 3 pages, 3 figures, Presented at Conference on Quarks and Nuclear Physics (QNP 2002), Julich, Germany, 9-14 Jun 200

Total and Differential Cross Sections for the pp-->pp eta-prime Reaction Near Threshold

The eta-prime meson production in the reaction pp-->pp eta-prime has been studied at excess energies of Q = 26.5, 32.5 and 46.6 MeV using the internal beam facility COSY-11 at the cooler synchrotron COSY. The total cross sections as well as one angular distribution for the highest Q-value are presented. The excitation function of the near threshold data can be described by a pure s-wave phase space distribution with the inclusion of the proton-proton final state interaction and Coulomb effects. The obtained angular distribution of the eta-prime mesons is also consistent with pure s-wave production.Comment: 6 pages, 5 figures, submitted to Eur. Phys. J.

Eta physics at threshold

The production of eta and eta-prime mesons in elementary nucleon-nucleon collisions has been investigated at the synchrotrons CELSIUS, COSY and SATURNE. The magnitude and energy dependence of the total cross section as well as the occupation distribution of the phase space serve as observables for investigating the mechanisms underlying the production processes and the interaction of mesons with nucleons. The precise data on the eta and eta-prime creation via the pp --> pp eta(eta-prime) reactions allowed to settle the general features of the eta and eta-prime meson production and revealed the sensitivity of the mentioned observables to the nucleon-nucleon-meson final state interaction. The particular production properties, like for example the determination of the dominating exchange processes which lead to the excitation of the S_11 nucleon isobar in the case of eta creation, must be established by confrontation with other observables. The present status of this investigation with an emphasis on the results of the COSY-11 collaboration is briefly presented. The available data are interpreted in view of the production mechanism and the meson-nucleon interaction.Comment: 3 pages, 3 figures, Presented at Conference on Quarks and Nuclear Physics (QNP 2002), Julich, Germany, 9-14 Jun 200