Laurent series expansion of a class of massive scalar one-loop integrals up to {\cal O}(\ep^2) in terms of multiple polylogarithms

In a recent paper we have presented results for a set of massive scalar one-loop master integrals needed in the NNLO parton model description of the hadroproduction of heavy flavors. The one--loop integrals were evaluated in n=4-2\ep dimension and the results were presented in terms of a Laurent series expansion up to {\cal O}(\ep^2). We found that some of the \ep^2 coefficients contain a new class of functions which we termed the $L$ functions. The $L$ functions are defined in terms of one--dimensional integrals involving products of logarithm and dilogarithm functions. In this paper we derive a complete set of algebraic relations that allow one to convert the $L$ functions of our previous approach to a sum of classical and multiple polylogarithms. Using these results we are now able to present the \ep^2 coefficients of the one-loop master integrals in terms of classical and multiple polylogarithms.Comment: 32 pages, Latex, references added, matches published versio

Density-functional theory investigation of oxygen adsorption at Pd(11N)(N=3,5,7) vicinal surfaces

We present a density-functional theory study addressing the on-surface adsorption of oxygen at the Pd(11N) (N =3,5,7) vicinal surfaces, which exhibit (111) steps and (100) terraces of increasing width. We find the binding to be predominantly governed by the local coordination at the adsorption site. This leads to very similar bonding properties at the threefold step sites of all three vicinal surfaces, while the binding at the central fourfold hollow site in the four atomic row terrace of Pd(117) is already very little disturbed by the presence of the neighboring steps.Comment: 9 pages including 4 figures; related publications can be found at http://www.fhi-berlin.mpg.de/th/th.htm

Short Term Performance of Bituminous Geomembranes with Respect to Temperature Variations

There is a significant lack of independentunbiased, peer-reviewed research on the performance of bituminous geomembranes in barrier system applications when compared to the standard barrier polymers used in industry today. The purpose of the research presented in this thesis is to help form a foundation of objective data on BGMbituminous geomembranes (BGMs)s performance in the field, as well as to compare it to polymer barriers like high density polyethylene (HDPE)HDPE geomembranes, LLDPElinear low density (LLDPE) geomembranes, and other well known material types. In addition, in Saskatchewan, the temperature can vary by more than 60°C so a variety of climate conditions need to be considered when installing geomembrane covers. Due to temperature variability, the influence on temperature on the performance of bituminous geomembranes is one of the main variables considered in this research. A variety of different testing methods were evaluated during this research including multiple ASTM standards for geomembrane puncture and tearing, and short-term performance testing; all with variations in temperature included in the testing procedures. The ASTM style testing methods used the ASTM designated apparatus, while the short-term performance testing was performed using equipment designed and manufactured in the College of Engineering Shops. When evaluating the puncture resistances of both BGMs and HDPE geomembranes, it was found that as temperatures increase, the displacement required to cause puncture also increasesthere was a positive correlation between the ambient temperature and the amount of displacement that occurs prior to puncture. In contrast to this, the puncture resistance of the samples themselves decrease as temperatures increase, while there was a negative correlation between the puncture resistance of the samples and the ambient temperature. During the sub-zero experiments, it was observed that the stiffness of the geomembranes increased. Additionally, while HDPE geomembranes showed higher overall loads at the time of puncture, the BGMs deformed in much more elastic manners allowing them to reform into their original shape due to the viscosityductility of the bitumen binding, which could be highly beneficial in application. When looking at the short-term performance of BGMs, in applications with the presence of aggressive over liners with the potential to cause puncture, it was found that both the ES2 and ES4BGM samplesproducts were able to withstand applied stresses of up to 400 kPa without any holes being caused in the barrier. Additionally, at lower temperatures there was little to no surface deformation present on the samples, with very minimal damage from the aggressive over liner. Based on the findings of this research, it was observed that HDPE retains a higher resistance to puncture than BGMs, however the highly viscous nature of BGMs shows that it could have many advantages in short-term performance depending on the conditions in which it is used

Feasibility study for thixoforming nanostructured bainitic steels

Super Bainite Steel (0.74% C, 1.64% Si, 1.82% Mn, 1% Ni, 0.36% Mo, 0. 21% Cr, 0.047% Al bal. Fe) after cold plastic deformation was used as the starting material for the bainitic treatment preceded by controlled cooling from the thixoforming temperature range. The Differential Scanning Calorimetry was used to determine the amount of the liquid phase fraction vs temperature in the solidus-liquidus range. The steel was heated up to 1430 °C, which corresponded to about 30% of the liquid fraction. Then it was rapidly cooled in oil at three different temperatures: 240 °C, 270 °C and 300 °C. The samples were then held at those temperatures for 5 h. The microstructure of the samples after treatment at 240 °C showed globular grains (average size of 115 µm), containing carbide-free bainite as a mixture of ferrite plates with average thickness of 63 nm, and retained austenite plates of thickness 40 nm. Plates of martensite and blocks of austenite were visible in some grain. X-ray studies confirmed the presence of 20.1 % of austenite and 79.9% of ferrite with martensite. The sample revealed the highest compression strength of 6651 MPa, at yield strength of 1780 MPa and compression strain ε=38%. With the increase of isothermal treatment temperature up to 270 ˚C and 300 ˚C, yield strength decreased to 1370 MPa, 1375 MPa and compression strength was 5243 MPa, 4138 MPa, respectively, while plastic strain reached 38.5% and 25 %, respectively. Higher temperature of bainitic treatment led to coarsening of super bainite plates and, in consequence to a decrease in mechanical properties. Initiation of crack propagation was observed at grains. They spread through the globules and eutectic, unlike in thixoformed tool steels, in which the crack path runs along the eutectic mixture between the globular grains. Preliminary studies of the corrosion resistance of Super Bainite steels containing carbide-free bainite structure were carried out. Results indicate slightly higher resistance in chlorides environment of the sample isothermally treated at 240 °C/5 h preceded by controlled cooling from thixoforming temperature range than the sample treated in the conventional way (1000 ˚C/15 min/240 ˚C/20 h).The research was supported by Polish science financial resources Applied Research Programme of the National Centre for Research and Development in Poland; “Developing a technology of producing complex elements by steel thixoforming”PBS1/B5/22/2013.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.msea.2015.10.08

О ЛЕЧЕБНОЙ РАБОТЕ НИИ СКОРОЙ ПОМОЩИ ИМ. Н.В. СКЛИФОСОВСКОГО В 2013 ГОДУ

About clinical work in Sklifosovsky research Institute for Emergency Medicine in 2013.Представляем Вашему вниманию мнение заместителя директора по лечебной работе НИИ СП им. Н.В. Склифосовского — главного врача института профессора Михаила Леонидовича Рогаля о лечебной работе НИИ скорой помощи им. Н.В. Склифосовского в 2013 году

О КЛИНИЧЕСКОЙ РАБОТЕ НИИ СП ИМ. Н.В. СКЛИФОСОВСКОГО

About clinical work in Sklifosovsky Research Institute for Emergency Medicine.Мы поинтересовались мнением заместителя директора НИИ СП им. Н.В. Склифосовского по лечебной работе — главным врачом института профессором М.Л. Рогалем о настоящем состоянии клинической деятельности института

Laurent series expansion of a class of massive scalar one-loop integrals to ${\cal O}(\ep^2)

We use dimensional regularization to calculate the {\cal O}(\ep^2) expansion of all scalar one-loop one-, two-, three- and four-point integrals that are needed in the calculation of hadronic heavy quark production. The Laurent series up to {\cal O}(\ep^2) is needed as input to that part of the NNLO corrections to heavy flavor production at hadron colliders where the one-loop integrals appear in the loop-by-loop contributions. The four-point integrals are the most complicated. The {\cal O}(\ep^2) expansion of the three- and four-point integrals contains in general polylogarithms up to ${\rm Li}_4$ and functions related to multiple polylogarithms of maximal weight and depth four.Comment: 48 pages, 4 figures in the text, slight change in the title, one reference added, matches published versio

Влияние полиморфизмов генов CYP2D6 и CYP2C9 на клиническую эффективность трамадола и кеторолака при использовании протокола ускоренного восстановления у пациентов с неосложненным острым калькулезным холециститом, перенесших холецистэктомию

Relevance. One of the key components of the accelerated recovery protocols (ARP), in addition to minimizing the surgical approach, is an adequate postoperative analgesia. Despite this, applied postoperative analgesia combinations are not devoid of drawbacks, such as lack of effective postoperative analgesia and the presence of side effect. The use of a pharmacogenetic approach to analgesic therapy for the purpose of its personalization may increase the effectiveness and safety of the use of analgesics. In particular, the presence of an inactive CYP2D6*4 allele , in which the conversion of tramadol to its active metabolite is reduced, contributes to the insufficient efficacy of the drug. As for non-steroidal anti-inflammatory drugs, the presence of CYP2C9*2/*3 polymorphisms leads to a decrease in drug metabolism and a longer half-life, resulting in the increase of the clinical effect and the risk of adverse reactions. Thus, genotyping of patients with the determination of the presence of specific genetic factors can rationalize the postoperative analgesia.Aim of study. Evaluation of the possible association of polymorphisms of the CYP2D6 and CYP2C9 genes with the clinical efficacy of tramadol and ketorolac in relation to postoperative pain.Material and methods. This observational clinical study involved 107 patients with uncomplicated acute calculous cholecystitis who underwent videolaparoscopic cholecystectomy and perioperative treatment according to ARP. All patients underwent whole blood sampling followed by real-time polymerase chain reaction genotyping. Analgesic efficacy was assessed using a visual analog scale (VAS) and McGill Pain Questionnaire.Results. In CYP2D64* carriers pain was higher than that of wild-type carriers, according to VAS and McGill Pain Questionnaire in all investigated periods. In carriers of CYP2C9*2, the pain syndrome was lower than in carriers of the wild type at all intervals studied. In carriers of CYP2C9*3 pain was lower only after 2 and 6 hours, also according to McGill Pain Questionnaire.Conclusion. 1. The presence of the polymorphic marker CYP2D6*4 may reduce the efficacy of postoperative tramadol analgesia compared with wild type. 2. The presence of the polymorphic marker CYP2C9*2 and CYP2C9*3 may increase the efficacy of ketorolac pain relief compared to wild type.Актуальность. Одним из ключевых компонентов всех протоколов ускоренного восстановления (ПУВ), помимо минимизации операционного доступа, является адекватная послеоперационная аналгезия. Несмотря на это применяемые комбинации послеоперационного обезболивания не лишены недостатков, таких как недостаточно эффективная послеоперационная аналгезия и наличие побочных эффектов от используемых препаратов. Применение фармакогенетического подхода к обезболивающей терапии с целью ее персонализации может повысить эффективность и безопасность применения анальгетиков. В частности, наличие неактивного аллеля CYP2D6*4, при котором снижено преобразование трамадола в его активный метаболит, способствует недостаточной эффективности препарата. Что касается нестероидных противовоспалительных препаратов, наличие полиморфизмов CYP2C9*2/*3 приводит к снижению метаболизма лекарств и более длительному периоду полувыведения, вследствие чего может усилиться клинический эффект и повыситься риск нежелательных реакций. Таким образом генотипирование пациентов с определением наличия конкретных генетических полиморфизмов может рационализировать послеоперационную аналгезию.Цель. Оценка возможной ассоциации полиморфизмов генов CYP2D6 и CYP2C9 с клинической эффективностью трамадола и кеторолака в отношении послеоперационной боли.Материал и методы. В этом обсервационном клиническом исследовании принимали участие 107 пациентов с неосложненным острым калькулезным холециститом, которым выполняли видеолапароскопическую холецистэктомию и проводили периоперационное лечение согласно оптимизированному ПУВ. Всем пациентам осуществлялся забор цельной крови с последующим генотипированием методом полимеразной цепной реакции в режиме реального времени. Обезболивающая эффективность оценивалась при помощи визуальной аналоговой шкалы (ВАШ) и опросника боли Мак-Гилла.Результаты. У носителей CYP2D6*4 болевой синдром был выше, чем у носителей дикого типа, по данным ВАШ и болевого опросника Мак-Гилла во все исследуемые промежутки. У носителей CYP2C9*2 болевой синдром был ниже, чем у носителей дикого типа во все исследуемые промежутки. У носителей CYP2C9*3 болевой синдром был ниже только через 2 и 6 часов, а также по данным оценочной шкалы боли Мак-Гилла.Выводы. 1. Наличие полиморфного маркера CYP2D6*4 может снизить эффективность послеоперационного обезболивания трамадолом по сравнению с диким типом. 2. Наличие полиморфного маркера CYP2C9*2 и CYP2C9*3 может повысить эффективность обезболивания кеторолаком по сравнению с диким типом

High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5

<p>Abstract</p> <p>Background</p> <p>Forward genetic screens in mice provide an unbiased means to identify genes and other functional genetic elements in the genome. Previously, a large scale ENU mutagenesis screen was conducted to query the functional content of a ~50 Mb region of the mouse genome on proximal Chr 5. The majority of phenotypic mutants recovered were embryonic lethals.</p> <p>Results</p> <p>We report the high resolution genetic mapping, complementation analyses, and positional cloning of mutations in the target region. The collection of identified alleles include several with known or presumed functions for which no mutant models have been reported (<it>Tbc1d14</it>, <it>Nol14</it>, <it>Tyms</it>, <it>Cad</it>, <it>Fbxl5</it>, <it>Haus3</it>), and mutations in genes we or others previously reported (<it>Tapt1</it>, <it>Rest</it>, <it>Ugdh</it>, <it>Paxip1</it>, <it>Hmx1, Otoe, Nsun7</it>). We also confirmed the causative nature of a homeotic mutation with a targeted allele, mapped a lethal mutation to a large gene desert, and localized a spermiogenesis mutation to a region in which no annotated genes have coding mutations. The mutation in <it>Tbc1d14 </it>provides the first implication of a critical developmental role for RAB-GAP-mediated protein transport in early embryogenesis.</p> <p>Conclusion</p> <p>This collection of alleles contributes to the goal of assigning biological functions to all known genes, as well as identifying novel functional elements that would be missed by reverse genetic approaches.</p