Segmentation of Sedimentary Grain in Electron Microscopy Image

This paper describes a novel method developed for the segmentation of sedimentary grains in electron microscopy images. The algorithm utilizes the approach of region splitting and merging. In the splitting stage, the marker-based watershed segmentation is used. In the merging phase, the typical characteristics of grains in electron microscopy images are exploited for proposing special metrics, which are then used during the merging stage to obtain a correct grain segmentation. The metrics are based on the typical intensity changes on the grain borders and the compact shape of grains. The experimental part describes the optimal setting of parameter in the splitting stage and the overall results of the proposed algorithm tested on available database of grains. The results show that the proposed technique fulfills the requirements of its intended application

Defining obstructive sleep apnoea syndrome: a failure of semantic rules

Obstructive sleep apnoea syndrome (OSAS) is one of the most ubiquitous medical conditions in industrialised society. Since the recognition that symptoms of excessive daytime somnolence, problems with concentration, mood and cognitive impairment, as well as cardiometabolic abnormalities can arise as a consequence of obstructed breathing during sleep, it has been subject to variation in its definition. Over the past five decades, attempts have been made to standardise the definitions and scoring criteria used for apnoeas and hypopnoea, which are the hallmarks of obstructive sleep apnoea (OSA). However, applying these definitions in clinical and research practice has resulted in over- and under-estimation of the severity and prevalence of OSAS. Furthermore, the definitions may eventually become redundant in the context of rapid technological advances in breathing measurement and other signal acquisition. Increased efforts towards precision medicine have led to a focus on the pathophysiology of obstructed breathing during sleep. However, the same degree of effort has not been focused on how and why the latter does or does not result in diurnal symptoms, integral to the definition of OSAS. This review focuses on OSAS in adults and discusses some of the difficulties with current definitions and the possible reasons behind them

The COVID-19 Pandemic and its Influence on the Human Immune System

COVID-19 rapidly infected the world, and scientists continue to research how the disease spread and killed as many as it did by analyzing how it affects the human immune system and referring to past pandemics. Since the pandemic is ongoing, scientists do not fully understand how the virus works and if lockdowns were effective. Nevertheless, a discussion on what is known about COVID-19\u27s influence on the human immune system is needed. With an understanding of the COVID-19 pandemic, scientists can make more effective treatments for COVID-19 and learn how to manage future pandemics

The obstructive sleep apnoea/hypopnoea syndrome – An overview

AbstractIn the last 30 years, there has been an explosion in facilities for the diagnosis and treatment of the obstructive sleep apnoea/hypopnoea syndrome (OSAHS) as well as a rapid advancement in the understanding of its consequences. In the general population, the prevalence of OSAHS is approximately 3–7% in adult men and 2–5% in adult women. OSAHS has been recognised as an independent risk factor for disorders such as hypertension, cardiovascular disease and sleepiness-related accidents. Currently, it is considered to be a systemic disease. This review provides a general overview of OSAHS: its epidemiology, pathophysiology, clinical features, diagnosis and treatment, as well as its consequences for public health

Breathe: respiratory health and disability

The December issue of Breathe looks at respiratory health in people with disabilities http://ow.ly/Vn9y305KcL

The phenotype and genotype of adult obstructive sleep apnoea/hypopnoea syndrome

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldObstructive sleep apnoea/hypopnoea syndrome (OSAHS) is a common condition affecting approximately 2-4% of the middle-aged population. A hereditary component to the condition has long been recognised but its genetic basis has been difficult to elucidate. Progress in determining the genotype of OSAHS is hampered by the lack of a consistent definition of phenotype and the large environmental influences on its expression. "Intermediate phenotypes", such as craniofacial structure, obesity and upper airway control, have been utilised. Multiple gene polymorphisms have been explored in association with the latter, as well as with the sequelae of OSAHS, such as hypertension and increased insulin resistance. To date, two genome-wide scans have identified potential regions that may be of interest in further defining the intermediate phenotypes. The present paper focuses on human studies with an update of the most recent work in the area, including a short discussion on methods of genetic studies

European Union directive 2014/85/EU on driver licensing in obstructive sleep apnoea:early experiences with its application in the UK

OSA patients’ risk of RTA should be assessed using detailed driving history with specific focus on “red flags” http://ow.ly/mxPi305isn

Sex and gender in lung health and disease: more than just Xs and Ys

A new series explores the role of sex and gender-related factors in respiratory physiology, lung health, and across respiratory diseases https://bit.ly/3mP0BV

Breathe:exploring respiratory health and exercise

The June issue of Breathe explores topics relating to respiratory health and exercise http://ow.ly/L3Zy300oWU

Breathe:New features and new ways to get involved

Breathe’s new Chief Editor welcomes us to the next three years http://ow.ly/UHuy