Human Health Effects Assays

Discussion of the exponential increase in environmental toxicological information and an approach for organizing and using the information was presented by Lu and Wassom.1 A user\u27s guide to the Registry of Toxic Effects of Chemical Substances (RTECS) was published by NIOSH2 that defines the record layouts and describes the types of data contained in the computer tape version of the 1984 Edition of the RTECS.3 A text summarizing information on approximately 800 toxic chemicals was edited by Sittig.4 Milestone publications concerning fundamentals of toxicology with environmental applications included the works of Gentile,5 Ashby,6 Mortel mans,7 Thacker,8 and Ruppert.9 Brusick and Auletta10 discussed the developmental status of bioassays in genetic toxicology reviewed by the U. S. Environmental Protection Agency (EPA) Gene-Tox Work Groups

User's Manual for FSLIP-3, FLEXSTAB Loads Integration Program

The FSLIP program documentation and user's manual is presented. As a follow on program to the FLEXSTAB computer analysis system, the primary function of this FORTRAN IV program is to integrate panel pressure coefficients computed by FLEXSTAB to obtain total shear, bending, and torque airloads on various surfaces, summed relative to user specified axes. The program essentially replaces the ALOADS module in FLEXSTAB with expanded capabilities and flexibility. As such, FSLIP is generalized to work on any FLEXSTAB model or other pressure data if in a compatible format

Bioremediation of Contaminated Surface Soils

Biological remediation of soils contaminated with organic chemicals is an alternative treatment technology that can often meet the goal of achieving a permanent clean-up remedy at hazardous waste sites, as encouraged by the U.S. Environmental Protection Agency (U.S. EPA) for implementation of The Superfund Amendments and Authorization Act (SARA) of 1986. Bioremediation is consistent with the philosophical thrust of SARA, for it involves the use of naturally occurring microorganisms to degrade and/or detoxify hazardous constituents in the soil at a contaminated slip to protect public health and the environment.Bioremediation of contaminated soils, including applications and limitations, has been addressed

In Situ Bioremediation of Contaminated Unsaturated Subsurface Soils

An emerging technology for the remediation of unsaturated subsurface soils involves the use of microorganisms to degrade contaminants which are present in such soils. Understanding the processes which drive in situ bioremediation, as well as the effectiveness and efficiency of the utilization of these systems, are issues which have been identified by the Regional Superfund Engineering Forum as concerns of Superfund decision makers

Short-Chained Oligo(Ethylene Oxide)-Functionalized Gold Nanoparticles: Realization Of Significant Protein Resistance

Protein corona formed on nanomaterial surfaces play an important role in the bioavailability and cellular uptake of nanomaterials. Modification of surfaces with oligoethylene glycols (OEG) are a common way to improve the resistivity of nanomaterials to protein adsorption. Short-chain ethylene oxide (EO) oligomers have been shown to improve the protein resistance of planar Au surfaces. We describe the application of these EO oligomers for improved protein resistance of 30 nm spherical gold nanoparticles (AuNPs). Functionalized AuNPs were characterized using UV-Vis spectroscopy, dynamic light scattering (DLS), and zeta potential measurements. Capillary electrophoresis (CE) was used for separation and quantitation of AuNPs and AuNP-protein mixtures. Specifically, nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM) was employed for the determination of equilibrium and rate constants for binding between citrate-stabilized AuNPs and two model proteins, lysozyme and fibrinogen. Semi-quantitative CE analysis was carried out for mixtures of EO-functionalized AuNPs and proteins, and results demonstrated a 2.5-fold to 10-fold increase in protein binding resistance to lysozyme depending on the AuNP surface functionalization and a 15-fold increase in protein binding resistance to fibrinogen for both EO oligomers examined in this study

Successfully Teaching Ethics For Effective Learning

This paper is concerned with identifying keys to successfully teach ethics. The keys are: addressing the relevance challenge; striving to achieve a balance between the active engagement of students with issues and a critical analysis of choices in to be made in real-life situations; attending to or managing the learning process to include learning styles and experiential learning; debriefing experientially-oriented learning activities; and institutionalizing outcomes of ethics education objectives. The paper discusses results of a study that attempted to answer the question “What is required to successfully deliver experientially-oriented ethics educatio

Beagle to the Moon: nn experiment package to measure polar ice and volatiles in permanently shadowed areas or beneath the lunar surface

The Beagle Science Package is a flight qualified set of instruments which should be deployed to the lunar surface to answer the questions about water and volatiles present in permanently shadowed regions and/or beneath the surface