320 research outputs found
Anomalous fluctuations of active polar filaments
Using a simple model, we study the fluctuating dynamics of inextensible,
semiflexible polar filaments interacting with active and directed force
generating centres such as molecular motors. Taking into account the fact that
the activity occurs on time-scales comparable to the filament relaxation time,
we obtain some unexpected differences between both the steady-state and
dynamical behaviour of active as compared to passive filaments. For the
statics, the filaments have a {novel} length-scale dependent rigidity.
Dynamically, we find strongly enhanced anomalous diffusion.Comment: 5 pages, 3 figure
Requirements for contractility in disordered cytoskeletal bundles
Actomyosin contractility is essential for biological force generation, and is
well understood in highly organized structures such as striated muscle.
Additionally, actomyosin bundles devoid of this organization are known to
contract both in vivo and in vitro, which cannot be described by standard
muscle models. To narrow down the search for possible contraction mechanisms in
these systems, we investigate their microscopic symmetries. We show that
contractile behavior requires non-identical motors that generate large enough
forces to probe the nonlinear elastic behavior of F-actin. This suggests a role
for filament buckling in the contraction of these bundles, consistent with
recent experimental results on reconstituted actomyosin bundles.Comment: 10 pages, 6 figures; text shortene
The Dynamics of a Meandering River
We present a statistical model of a meandering river on an alluvial plane
which is motivated by the physical non-linear dynamics of the river channel
migration and by describing heterogeneity of the terrain by noise. We study the
dynamics analytically and numerically. The motion of the river channel is
unstable and we show that by inclusion of the formation of ox-bow lakes, the
system may be stabilised. We then calculate the steady state and show that it
is in agreement with simulations and measurements of field data.Comment: Revtex, 12 pages, 2 postscript figure
The Phylogeography of Rabies in Grenada, West Indies, and Implications for Control
In Grenada, West Indies, rabies is endemic, and is thought to be maintained in a wildlife host, the small Indian mongoose (Herpestes auropunctatus) with occasional spillover into other hosts. Therefore, the present study was undertaken to improve understanding of rabies epidemiology in Grenada and to inform rabies control policy. Mongooses were trapped island-wide between April 2011 and March 2013 and examined for the presence of Rabies virus (RABV) antigen using the direct fluorescent antibody test (dFAT) and PCR, and for serum neutralizing antibodies (SNA) using the fluorescent antibody virus neutralization test (FAVN). An additional cohort of brain samples from clinical rabies suspects submitted between April 2011 and March 2014 were also investigated for the presence of virus. Two of the 171 (1.7%) live-trapped mongooses were RABV positive by FAT and PCR, and 20 (11.7%) had SNAs. Rabies was diagnosed in 31 of the submitted animals with suspicious clinical signs: 16 mongooses, 12 dogs, 2 cats and 1 goat. Our investigation has revealed that rabies infection spread from the northeast to the southwest of Grenada within the study period. Phylogenetic analysis revealed that the viruses from Grenada formed a monophyletic clade within the cosmopolitan lineage with a common ancestor predicted to have occurred recently (6–23 years ago), and are distinct from those found in Cuba and Puerto Rico, where mongoose rabies is also endemic. These data suggest that it is likely that this specific strain of RABV was imported from European regions rather than the Americas. These data contribute essential information for any potential rabies control program in Grenada and demonstrate the importance of a sound evidence base for planning interventions
Self-organization and Mechanical Properties of Active Filament Bundles
A phenomenological description for active bundles of polar filaments is
presented. The activity of the bundle results from crosslinks, that induce
relative displacements between the aligned filaments. Our generic description
is based on momentum conservation within the bundle. By specifying the internal
forces, a simple minimal model for the bundle dynamics is obtained, capturing
generic dynamic behaviors. In particular, contracted states as well as solitary
and oscillatory waves appear through dynamic instabilities. The introduction of
filament adhesion leads to self-organized persistent filament transport.
Furthermore, calculating the tension, homogeneous bundles are shown to be able
to actively contract and to perform work against external forces. Our
description is motivated by dynamic phenomena in the cytoskeleton and could
apply to stress-fibers and self-organization phenomena during cell-locomotion.Comment: 19 pages, 10 figure
Structure formation in active networks
Structure formation and constant reorganization of the actin cytoskeleton are
key requirements for the function of living cells. Here we show that a minimal
reconstituted system consisting of actin filaments, crosslinking molecules and
molecular-motor filaments exhibits a generic mechanism of structure formation,
characterized by a broad distribution of cluster sizes. We demonstrate that the
growth of the structures depends on the intricate balance between
crosslinker-induced stabilization and simultaneous destabilization by molecular
motors, a mechanism analogous to nucleation and growth in passive systems. We
also show that the intricate interplay between force generation, coarsening and
connectivity is responsible for the highly dynamic process of structure
formation in this heterogeneous active gel, and that these competing mechanisms
result in anomalous transport, reminiscent of intracellular dynamics
Stiff polymer in monomer ensemble
We make use of the previously developed formalism for a monomer ensemble and
include angular dependence of the segments of the polymer chains thus
described. In particular we show how to deal with stiffness when the polymer
chain is confined to certain regions. We investigate the stiffness from the
perspectives of a differential equation, integral equations, or recursive
relations for both continuum and lattice models. Exact analytical solutions are
presented for two cases, whereas numerical results are shown for a third case.Comment: 10 pages, including 6 figure
Short-time inertial response of viscoelastic fluids measured with Brownian motion and with active probes
We have directly observed short-time stress propagation in viscoelastic
fluids using two optically trapped particles and a fast interferometric
particle-tracking technique. We have done this both by recording correlations
in the thermal motion of the particles and by measuring the response of one
particle to the actively oscillated second particle. Both methods detect the
vortex-like flow patterns associated with stress propagation in fluids. This
inertial vortex flow propagates diffusively for simple liquids, while for
viscoelastic solutions the pattern spreads super-diffusively, dependent on the
shear modulus of the medium
Invaded cluster simulations of the XY model in two and three dimensions
The invaded cluster algorithm is used to study the XY model in two and three
dimensions up to sizes 2000^2 and 120^3 respectively. A soft spin O(2) model,
in the same universality class as the 3D XY model, is also studied. The static
critical properties of the model and the dynamical properties of the algorithm
are reported. The results are K_c=0.45412(2) for the 3D XY model and
eta=0.037(2) for the 3D XY universality class. For the 2D XY model the results
are K_c=1.120(1) and eta=0.251(5). The invaded cluster algorithm does not show
any critical slowing for the magnetization or critical temperature estimator
for the 2D or 3D XY models.Comment: 30 pages, 11 figures, problem viewing figures corrected in v
Young People Who Meaningfully Improve Are More Likely to Mutually Agree to End Treatment
Objective: Symptom improvement is often examined as an indicator of a good outcome of accessing mental health services. However, there is little evidence of whether symptom improvement is associated with other indicators of a good outcome, such as a mutual agreement to end treatment. The aim of this study was to examine whether young people accessing mental health services who meaningfully improved were more likely to mutually agree to end treatment. /
Methods: Multilevel multinomial regression analysis controlling for age, gender, ethnicity, and referral source was conducted on N = 8,995 episodes of care [Female = 5,469, 61%; meanAge = 13.66 (SD = 2.87) years] using anonymised administrative data from young people's mental health services. /
Results: Compared to young people with no change in mental health difficulties, those showing positive meaningful changes in mental health difficulties were less likely to have case closure due to non-mutual agreement (Odds Ratio or OR = 0.58, 95% Confidence Interval or CI = 0.50–0.61). Similarly, they were less likely to transfer (OR = 0.61, 95% CI = 0.49–0.74) or end treatment for other reasons (OR = 0.59, 95% CI = 0.50–0.70) than by case closure due to mutual agreement. /
Conclusion: The findings suggest that young people accessing mental health services whose symptoms meaningfully improve are more likely to mutually agree to end treatment, adding to the evidence that symptom improvement may be appropriate to examine as an indicator of a good outcome of accessing mental health services
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