192 research outputs found
A practical guide to density matrix embedding theory in quantum chemistry
Density matrix embedding theory (DMET) provides a theoretical framework to
treat finite fragments in the presence of a surrounding molecular or bulk
environment, even when there is significant correlation or entanglement between
the two. In this work, we give a practically oriented and explicit description
of the numerical and theoretical formulation of DMET. We also describe in
detail how to perform self-consistent DMET optimizations. We explore different
embedding strategies with and without a self-consistency condition in hydrogen
rings, beryllium rings, and a sample S2 reaction. The source code
for the calculations in this work can be obtained from
\url{https://github.com/sebwouters/qc-dmet}.Comment: 41 pages, 10 figure
Exploring interfacial exchange coupling and sublattice effect in heavy metal/ferrimagnetic insulator heterostructures using Hall measurements, x-ray magnetic circular dichroism, and neutron reflectometry
We use temperature-dependent Hall measurements to identify contributions of
spin Hall, magnetic proximity, and sublattice effects to the anomalous Hall
signal in heavy metal/ferrimagnetic insulator heterostructures with
perpendicular magnetic anisotropy. This approach enables detection of both the
magnetic proximity effect onset temperature and the magnetization compensation
temperature and provides essential information regarding the interfacial
exchange coupling. Onset of a magnetic proximity effect yields a local extremum
in the temperature-dependent anomalous Hall signal, which occurs at higher
temperature as magnetic insulator thickness increases. This magnetic proximity
effect onset occurs at much higher temperature in Pt than W. The magnetization
compensation point is identified by a sharp anomalous Hall sign change and
divergent coercive field. We directly probe the magnetic proximity effect using
x-ray magnetic circular dichroism and polarized neutron reflectometry, which
reveal an antiferromagnetic coupling between W and the magnetic insulator.
Finally, we summarize the exchange-coupling configurations and the anomalous
Hall-effect sign of the magnetized heavy metal in various heavy metal/magnetic
insulator heterostructures
Cell Anchorage Permits Efficient Signal Transduction Between Ras and Its Downstream Kinases
Cell anchorage strongly affects the signal transduction cascade initiated by peptide mitogens. For both epidermal growth factor and platelet-derived growth factor, activation of the consensus mitogen-activated protein kinase cascade is impaired when cells are held in suspension as compared with cells anchored to a fibronectin substratum. Upstream events in the signaling cascade, including tyrosine phosphorylation of the mitogen receptor and GTP loading of Ras, are similar in anchored and suspended cells. However, propagation of the signal to Raf and subsequently to the downstream kinases MEK and mitogen-activated protein kinase is markedly attenuated in suspended cells. Thus, there seems to be a distinct anchorage-dependent step between Ras and Raf in the signaling cascade initiated by peptide mitogens. These observations may have important implications for understanding the anchorage dependence of cell growth
Role of dimensional crossover on spin-orbit torque efficiency in magnetic insulator thin films
Magnetic insulators (MIs) attract tremendous interest for spintronic
applications due to low Gilbert damping and absence of Ohmic loss. Magnetic
order of MIs can be manipulated and even switched by spin-orbit torques (SOTs)
generated through spin Hall effect and Rashba-Edelstein effect in heavy
metal/MI bilayers. SOTs on MIs are more intriguing than magnetic metals since
SOTs cannot be transferred to MIs through direct injection of electron spins.
Understanding of SOTs on MIs remains elusive, especially how SOTs scale with
the film thickness. Here, we observe the critical role of dimensionality on the
SOT efficiency by systematically studying the MI layer thickness dependent SOT
efficiency in tungsten/thulium iron garnet (W/TmIG) bilayers. We first show
that the TmIG thin film evolves from two-dimensional to three-dimensional
magnetic phase transitions as the thickness increases, due to the suppression
of long-wavelength thermal fluctuation. Then, we report the significant
enhancement of the measured SOT efficiency as the thickness increases. We
attribute this effect to the increase of the magnetic moment density in concert
with the suppression of thermal fluctuations. At last, we demonstrate the
current-induced SOT switching in the W/TmIG bilayers with a TmIG thickness up
to 15 nm. The switching current density is comparable with those of heavy
metal/ferromagnetic metal cases. Our findings shed light on the understanding
of SOTs in MIs, which is important for the future development of ultrathin
MI-based low-power spintronics
Fosamprenavir or atazanavir once daily boosted with ritonavir 100 mg, plus tenofovir/emtricitabine, for the initial treatment of HIV infection: 48-week results of ALERT
<p>Abstract</p> <p>Background</p> <p>Once-daily (QD) ritonavir 100 mg-boosted fosamprenavir 1400 mg (FPV/r100) or atazanavir 300 mg (ATV/r100), plus tenofovir/emtricitabine (TDF/FTC) 300 mg/200 mg, have not been compared as initial antiretroviral treatment. To address this data gap, we conducted an open-label, multicenter 48-week study (ALERT) in 106 antiretroviral-naïve, HIV-infected patients (median HIV-1 RNA 4.9 log<sub>10 </sub>copies/mL; CD4+ count 191 cells/mm<sup>3</sup>) randomly assigned to the FPV/r100 or ATV/r100 regimens.</p> <p>Results</p> <p>At baseline, the FPV/r100 or ATV/r100 arms were well-matched for HIV-1 RNA (median, 4.9 log<sub>10 </sub>copies/mL [both]), CD4+ count (mean, 176 vs 205 cells/mm<sup>3</sup>). At week 48, intent-to-treat: missing/discontinuation = failure analysis showed similar responses to FPV/r100 and ATV/r100 (HIV-1 RNA < 50 copies/mL: 75% (40/53) vs 83% (44/53), p = 0.34 [Cochran-Mantel-Haenszel test]); mean CD4+ count change-from-baseline: +170 vs +183 cells/mm<sup>3</sup>, p = 0.398 [Wilcoxon rank sum test]). Fasting total/LDL/HDL-cholesterol changes-from-baseline were also similar, although week 48 median fasting triglycerides were higher with FPV/r100 (150 vs 131 mg/dL). FPV/r100-treated patients experienced fewer treatment-related grade 2–4 adverse events (15% vs 57%), with differences driven by ATV-related hyperbilirubinemia. Three patients discontinued TDF/FTC because their GFR decreased to <50 mL/min.</p> <p>Conclusion</p> <p>The all-QD regimens of FPV/r100 and ATV/r100, plus TDF/FTC, provided similar virologic, CD4+ response, and fasting total/LDL/HDL-cholesterol changes through 48 weeks. Fewer FPV/r100-treated patients experienced treatment-related grade 2–4 adverse events.</p
Metal-insulator transitions in anisotropic 2d systems
Several phenomena related to the critical behaviour of non-interacting
electrons in a disordered 2d tight-binding system with a magnetic field are
studied. Localization lengths, critical exponents and density of states are
computed using transfer matrix techniques. Scaling functions of isotropic
systems are recovered once the dimension of the system in each direction is
chosen proportional to the localization length. It is also found that the
critical point is independent of the propagation direction, and that the
critical exponents for the localization length for both propagating directions
are equal to that of the isotropic system (approximately 7/3). We also
calculate the critical value of the scaling function for both the isotropic and
the anisotropic system. It is found that the isotropic value equals the
geometric mean of the two anisotropic values. Detailed numerical studies of the
density of states for the isotropic system reveals that for an appreciable
amount of disorder the critical energy is off the band center.Comment: 6 pages RevTeX, 6 figures included, submitted to Physical Review
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