51,054 research outputs found
Skylab Trash Airlock
The Skylab Trash Airlock (TAL) used throughout the Skylab mission to transfer trash materials that could support microbial growth from the pressurized cabin to the unpressurized waste tank is described. The TAL, which uses several basic mechanisms, was successfully operated daily for the 170 days of manned missions for a total of 637 cycles
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Secondary centres of economic activity in the East Midlands: final report
This report outlines the findings of a study of secondary centres of economic activity in the East Midlands. The study builds on previous work undertaken in the ‘GDP Growth in the East Midlands and Yorkshire and Humberside regions’ project by the Enterprise Research and Development Unit on behalf of emda and Yorkshire Forward
LET-99 functions in the astral furrowing pathway, where it is required for myosin enrichment in the contractile ring.
The anaphase spindle determines the position of the cytokinesis furrow, such that the contractile ring assembles in an equatorial zone between the two spindle poles. Contractile ring formation is mediated by RhoA activation at the equator by the centralspindlin complex and midzone microtubules. Astral microtubules also inhibit RhoA accumulation at the poles. In the Caenorhabditis elegans one-cell embryo, the astral microtubule-dependent pathway requires anillin, NOP-1, and LET-99. LET-99 is well characterized for generating the asymmetric cortical localization of the Gα-dependent force-generating complex that positions the spindle during asymmetric division. However, whether the role of LET-99 in cytokinesis is specific to asymmetric division and whether it acts through Gα to promote furrowing are unclear. Here we show that LET-99 contributes to furrowing in both asymmetrically and symmetrically dividing cells, independent of its function in spindle positioning and Gα regulation. LET-99 acts in a pathway parallel to anillin and is required for myosin enrichment into the contractile ring. These and other results suggest a positive feedback model in which LET-99 localizes to the presumptive cleavage furrow in response to the spindle and myosin. Once positioned there, LET-99 enhances myosin accumulation to promote furrowing in both symmetrically and asymmetrically dividing cells
From ‘As Good as Gold’ to ‘Gold Diggers’: Farming Women and the Survival of British Family Farming
The survival of family farming in British agriculture has long been a topic of interest for
rural researchers and is undergoing something of a current renewal of interest. However,
insights from feminist approaches remain underutilised despite the crucial role farming
women continue to play in family farming. This article addresses the unity of farm,
family and business by interpreting it as a patriarchal way of life. An ethnographically
informed repeated life history methodology is employed to study in detail the family
members of seven farms in rural mid-Wales. Findings show that the recent survival of
the family farms investigated has been heavily dependent upon compliance with a
patriarchal ideology that demands that women be ‘as good as gold’. However, it is
discovered that a new view of women is emerging in the world of British family farming,
that of ‘gold digger’. Women entering relationships with farming men are increasingly
being considered a threat to farm survival by virtue of their entitlements if the relationship
breaks down. The necessity to study the intricacies of personal relationships in
family farming has important implications for most future research into this form of
agricultural business arrangement
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