295 research outputs found
Regression games
The solution of a TU cooperative game can be a distribution of the value of the grand coalition, i.e. it can be a distribution of the payo (utility) all the players together achieve. In a regression model, the evaluation of the explanatory variables can be a distribution of the overall t, i.e. the t of the model every regressor variable is involved. Furthermore, we can take regression models as TU cooperative games where the explanatory (regressor) variables are the players. In this paper we introduce the class of regression games, characterize it and apply the Shapley value to evaluating the explanatory variables in regression models. In order to support our approach we consider Young (1985)'s axiomatization of the Shapley value, and conclude that the Shapley value is a reasonable tool to evaluate the explanatory variables of regression models
SPIRE Point Source Catalog Explanatory Supplement
The Spectral and Photometric Imaging Receiver (SPIRE) was launched as one of
the scientific instruments on board of the space observatory Herschel. The
SPIRE photometer opened up an entirely new window in the Submillimeter domain
for large scale mapping, that up to then was very difficult to observe. There
are already several catalogs that were produced by individual Herschel science
projects. Yet, we estimate that the objects of only a fraction of these maps
will ever be systematically extracted and published by the science teams that
originally proposed the observations. The SPIRE instrument performed its
standard photometric observations in an optically very stable configuration,
only moving the telescope across the sky, with variations in its configuration
parameters limited to scan speed and sampling rate. This and the scarcity of
features in the data that require special processing steps made this dataset
very attractive for producing an expert reduced catalog of point sources that
is being described in this document. The Catalog was extracted from a total of
6878 unmodified SPIRE scan map observations. The photometry was obtained by a
systematic and homogeneous source extraction procedure, followed by a rigorous
quality check that emphasized reliability over completeness. Having to exclude
regions affected by strong Galactic emission, that pushed the limits of the
four source extraction methods that were used, this catalog is aimed primarily
at the extragalactic community. The result can serve as a pathfinder for ALMA
and other Submillimeter and Far-Infrared facilities. 1,693,718 sources are
included in the final catalog, splitting into 950688, 524734, 218296 objects
for the 250\mu m, 350\mu m, and 500\mu m bands, respectively. The catalog comes
with well characterized environments, reliability, completeness, and
accuracies, that single programs typically cannot provide
Extracellular deposition of matrilin-2 controls the timing of the myogenic program during muscle regeneration.
Here, we identify a role for the matrilin-2 (Matn2) extracellular matrix protein in controlling the early stages of myogenic differentiation. We observed Matn2 deposition around proliferating, differentiating and fusing myoblasts in culture and during muscle regeneration in vivo. Silencing of Matn2 delayed the expression of the Cdk inhibitor p21 and of the myogenic genes Nfix, MyoD and Myog, explaining the retarded cell cycle exit and myoblast differentiation. Rescue of Matn2 expression restored differentiation and the expression of p21 and of the myogenic genes. TGF-β1 inhibited myogenic differentiation at least in part by repressing Matn2 expression, which inhibited the onset of a positive-feedback loop whereby Matn2 and Nfix activate the expression of one another and activate myoblast differentiation. In vivo, myoblast cell cycle arrest and muscle regeneration was delayed in Matn2(-/-) relative to wild-type mice. The expression levels of Trf3 and myogenic genes were robustly reduced in Matn2(-/-) fetal limbs and in differentiating primary myoblast cultures, establishing Matn2 as a key modulator of the regulatory cascade that initiates terminal myogenic differentiation. Our data thus identify Matn2 as a crucial component of a genetic switch that modulates the onset of tissue repair
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