Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation.

BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar water solubility of a hydrocarbon could be used to predict receptor modulation in vitro.MethodsGABAA (α1β2γ2s) or NMDA (NR1/NR2A) receptors were expressed in oocytes and studied using standard two-electrode voltage clamp techniques. Hydrocarbons from 14 different organic functional groups were studied at saturated concentrations, and compounds within each group differed only by the carbon number at the ω-position or within a saturated ring. An effect on GABAA or NMDA receptors was defined as a 10% or greater reversible current change from baseline that was statistically different from zero.ResultsHydrocarbon moieties potentiated GABAA and inhibited NMDA receptor currents with at least some members from each functional group modulating both receptor types. A water solubility cut-off for NMDA receptors occurred at 1.1 mM with a 95% CI = 0.45 to 2.8 mM. NMDA receptor cut-off effects were not well correlated with hydrocarbon chain length or molecular volume. No cut-off was observed for GABAA receptors within the solubility range of hydrocarbons studied.ConclusionsHydrocarbon modulation of NMDA receptor function exhibits a molar water solubility cut-off. Differences between unrelated receptor cut-off values suggest that the number, affinity, or efficacy of protein-hydrocarbon interactions at these sites likely differ

An Iterative Detection Aided Unequal Error Protection Wavelet Video Scheme Using Irregular Convolutional Codes

A wavelet-based videophone scheme proposed, where the video bits are Unequal Error Protection (UEP) using Irregular Convolutional Codes (IRCCs). The proposed system uses Adaptive Arithmetic Coding (AAC) for encoding the motion vectors and individual wavelet subband coefficients. The turbo equalized IRCC-aided videophone scheme is capable of attaining a near unimpaired video quality for channel Signal-to-Noise Ratios (SNRs) in excess of about 4.5dB over a five-path dispersive AWGN channel

Preduals of semigroup algebras

For a locally compact group G, the measure convolution algebra M(G) carries a natural coproduct. In previous work, we showed that the canonical predual C 0(G) of M(G) is the unique predual which makes both the product and the coproduct on M(G) weak*-continuous. Given a discrete semigroup S, the convolution algebra ℓ 1(S) also carries a coproduct. In this paper we examine preduals for ℓ 1(S) making both the product and the coproduct weak*-continuous. Under certain conditions on S, we show that ℓ 1(S) has a unique such predual. Such S include the free semigroup on finitely many generators. In general, however, this need not be the case even for quite simple semigroups and we construct uncountably many such preduals on ℓ 1(S) when S is either ℤ+×ℤ or (ℕ,⋅)

The collective consciousness of Information Technology research: The significance and value of research projects. A. The views of IT researchers

This research seeks to reveal the different perceptual worlds in a research community, with the longterm intent of fostering increased understanding and hence collaboration. In the relatively new field of information technology (IT) research, available evidence suggests that a shared understanding of the research object or territory does not yet exist. This has led to the development of different perceptions amongst IT researchers of what constitutes significant and valuable research. A phenomenological approach is used to elicit data from a diverse range of IT researchers in semistructured interviews. This data is presented to show (1) the variation in meaning associated with the idea of significance and value and (2) the awareness structures through which participants experience significance and value. An Outcome Space represents the interrelation between those different ways of seeing, revealing a widening awareness. Five categories of ways of seeing the significance and value of research projects were found: The Personal Goals Conception, The Research Currency Conception, The Design of the Research Project Conception, The Outcomes for the Technology End User Conception and The Solving Real-World Problems Conception. These are situated within three wider perceptual boundaries: The Individual, The Research Community and Humankind. The categories are described in detail, demonstrated with participants’ quotes and illustrated with diagrams. A tentative comparison is made between this project and a similar investigation of IT professionals’ ways of seeing the significance and value of IT research projects. Finally, some recommendations for further research are made

The collective consciousness of Information Technology research: The significance and value of research projects. B. The views of IT industry professionals

This research seeks to reveal the different perceptual worlds in a research community, with the longterm intent of fostering increased understanding and hence collaboration. In the relatively new field of information technology (IT) research, available evidence suggests that a shared understanding of the research object or territory does not yet exist. This has led to the development of different perceptions amongst IT researchers of what constitutes significant and valuable research. Phenomenological methodology is used to elicit data from a diverse range of IT industry professionals in semi-structured interviews. This data is presented to show (1) the variation in meaning associated with the idea of significance and value and (2) the awareness structures through which participants experience significance and value. An Outcome Space represents the interrelation between those different ways of seeing, revealing a widening awareness. Five categories of ways of seeing the significance and value of research projects were found: The Personal Goals Conception, The Commercial Goals Conception, The Outcomes for the Technology End User Conception, The Solving Real-World Problems Conception and The Design of the Research Project Conception. These are situated within three wider perceptual boundaries: The Individual, The Enterprise and Society. The categories are described in detail, demonstrated with participants’ quotes and illustrated with diagrams. A tentative comparison is made between this project and a similar investigation of IT researchers’ ways of seeing the significance and value of IT research projects. Finally, some recommendations for further research are made

Application of Current Algebra in Three Pseudoscalar Meson Decays of τ\tau Lepton

The decays of $\tau \to 3\pi \nu$ and $\tau \to \pi K^{*} \nu, K\rho \nu$ are calculated using the hard pion and kaon current algebra and assuming the Axial-Vector meson dominance of the hadronic axial currents. Using the experimental data on their masses and widths, the $\tau$ decay branching ratios into these channels are calculated and found to be in a reasonable agreement with the experimental data. In particular, using the available Aleph data on the $3\pi$ spectrum, we determine the $A_1$ parameters, $m_A=1.24\pm 0.02 GeV$, $\Gamma _A=0.43\pm 0.02$ GeV; the hard current algebra calculation yields a $3\pi$ branching ratio of $19 \pm 3 \%$.Comment: 14 pages, Tex, 6 included figure

Sensing coherent dynamics of electronic spin clusters in solids

We present experimental observations and a study of quantum dynamics of strongly interacting electronic spins, at room temperature in the solid state. In a diamond substrate, a single nitrogen vacancy (NV) center coherently interacts with two adjacent S = 1/2 dark electron spins. We quantify NV-electron and electron-electron couplings via detailed spectroscopy, with good agreement to a model of strongly interacting spins. The electron-electron coupling enables an observation of coherent flip-flop dynamics between electronic spins in the solid state, which occur conditionally on the state of the NV. Finally, as a demonstration of coherent control, we selectively couple and transfer polarization between the NV and the pair of electron spins. These results demonstrate a key step towards full quantum control of electronic spin registers in room temperature solids

TBI Contusion Segmentation from MRI using Convolutional Neural Networks

Traumatic brain injury (TBI) is caused by a sudden trauma to the head that may result in hematomas and contusions and can lead to stroke or chronic disability. An accurate quantification of the lesion volumes and their locations is essential to understand the pathophysiology of TBI and its progression. In this paper, we propose a fully convolutional neural network (CNN) model to segment contusions and lesions from brain magnetic resonance (MR) images of patients with TBI. The CNN architecture proposed here was based on a state of the art CNN architecture from Google, called Inception. Using a 3-layer Inception network, lesions are segmented from multi-contrast MR images. When compared with two recent TBI lesion segmentation methods, one based on CNN (called DeepMedic) and another based on random forests, the proposed algorithm showed improved segmentation accuracy on images of 18 patients with mild to severe TBI. Using a leave-one-out cross validation, the proposed model achieved a median Dice of 0.75, which was significantly better (p<0.01) than the two competing methods.Comment: https://ieeexplore.ieee.org/abstract/document/8363545/, IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018