13,143 research outputs found

    Euthanasia: A Soft Paradigm for Medical Ethics

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    TNT equivalency of M10 propellant

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    Peak, side-on blast overpressure and scaled, positive impulse have been measured for M10 single-perforated propellant, web size 0.018 inches, using configurations that simulate the handling of bulk material during processing and shipment. Quantities of 11.34, 22.7, 45.4, and 65.8 kg were tested in orthorhombic shipping containers and fiberboard boxes. High explosive equivalency values for each test series were obtained as a function of scaled distance by comparison to known pressure, arrival time and impulse characteristics for hemispherical TNT surface bursts. The equivalencies were found to depend significantly on scaled distance, with higher values of 150-100 percent (pressure) and 350-125 percent (positive impulse) for the extremes within the range from 1.19 to 3.57 m/cube root of kg. Equivalencies as low as 60-140 percent (pressure) and 30-75 percent (positive impulse) were obtained in the range of 7.14 to 15.8 m/cube root of kg. Within experimental error, both peak pressure and positive impulse scaled as a function of charge weight for all quantities tested in the orthorhombic configuration

    Blood lactate clearance during active recovery after an intense running bout depends on the intensity of the active recovery

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    High-intensity exercise training contributes to the production and accumulation of blood lactate, which is cleared by active recovery. However, there is no commonly agreed intensity or mode for clearing accumulated blood lactate. We studied clearance of accumulated blood lactate during recovery at various exercise intensities at or below the lactate threshold after high-intensity interval runs that prompted lactate accumulation. Ten males repeated 5-min running bouts at 90% of maximal oxygen uptake ([Vdot]O2max), which increased blood lactate concentration from 1.0 ± 0.1 to 3.9 ± 0.3 mmol · l-1. This was followed by recovery exercises ranging from 0 to 100% of lactate threshold. Repeated blood lactate measurements showed faster clearance of lactate during active versus passive recovery, and that the decrease in lactate was more rapid during higher (60-100% of lactate threshold) than lower (0-40% of lactate threshold) (P < 0.05) intensities. The more detailed curve and rate analyses showed that active recovery at 80-100% of lactate threshold had shorter time constants for 67% lactate clearance and higher peak clearance rates than 40% of lactate threshold or passive recovery (P < 0.05). Finally, examination of self-regulated intensities showed enhanced lactate clearance during higher versus lower intensities, further validating the intensity dependence of clearance of accumulated blood lactate. Therefore, active recovery after strenuous exercise clears accumulated blood lactate faster than passive recovery in an intensity-dependent manner. Maximum clearance occurred at active recovery close to the lactate threshold

    Self-pulsing dynamics in a cavity soliton laser

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    The dynamics of a broad-area vertical-cavity surface-emitting laser (VCSEL) with frequency-selective feedback supporting bistable spatial solitons is analyzed experimentally and theoretically. The transient dynamics of a switch-on of a soliton induced by an external optical pulse shows strong self-pulsing at the external-cavity round-trip time with at least ten modes excited. The numerical analysis indicates an even broader bandwidth and a transient sweep of the center frequency. It is argued that mode-locking of spatial solitons is an interesting and viable way to achieve three-dimensional, spatio-temporal self-localization and that the transients observed are preliminary indications of a transient cavity light bullet in the dynamics, though on a non negligible background

    The Interaction between the ISM and Star Formation in the Dwarf Starburst Galaxy NGC 4214

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    We present the first interferometric study of the molecular gas in the metal-poor dwarf starburst galaxy NGC 4214. Our map of the 12CO(1-0) emission, obtained at the OVRO millimeter array, reveals an unexpected structural wealth. We detected three regions of molecular emission in the north-west (NW), south-east (SE) and centre of NGC 4214 which are in very different and distinct evolutionary stages (total molecular mass: 5.1 x 10^6 M_sun). These differences are apparent most dramatically when the CO morphologies are compared to optical ground based and HST imaging: massive star formation has not started yet in the NW region; the well-known starburst in the centre is the most evolved and star formation in the SE complex started more recently. We derive a star formation efficiency of 8% for the SE complex. Using high--resolution VLA observations of neutral hydrogen HI and our CO data we generated a total gas column density map for NGC 4214 (HI + H_2). No clear correlation is seen between the peaks of HI, CO and the sites of ongoing star formation. This emphasizes the irregular nature of dwarf galaxies. The HI and CO velocities agree well, so do the H-alpha velocities. In total, we cataloged 14 molecular clumps in NGC 4214. Our results from a virial mass analysis are compatible with a Galactic CO-to-H_2 conversion factor for NGC 4214 (lower than what is usually found in metal-poor dwarf galaxies).Comment: accepted for publication in the AJ (February 2001), full ps file at: ftp://ftp.astro.caltech.edu/users/fw/ngc4214/walter_prep.p

    Frequency and phase locking of laser cavity solitons

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    Self-localized states or dissipative solitons have the freedom of translation in systems with a homogeneous background. When compared to cavity solitons in coherently driven nonlinear optical systems, laser cavity solitons have the additional freedom of the optical phase. We explore the consequences of this additional Goldstone mode and analyse experimentally and numerically frequency and phase locking of laser cavity solitons in a vertical-cavity surface-emitting laser with frequency-selective feedback. Due to growth-related variations of the cavity resonance, the translational symmetry is usually broken in real devices. Pinning to different defects means that separate laser cavity solitons have different frequencies and are mutually incoherent. If two solitons are close to each other, however, their interaction leads to synchronization due to phase and frequency locking with strong similarities to the Adler-scenario of coupled oscillators

    Intersection tests for single marker QTL analysis can be more powerful than two marker QTL analysis

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    BACKGROUND: It has been reported in the quantitative trait locus (QTL) literature that when testing for QTL location and effect, the statistical power supporting methodologies based on two markers and their estimated genetic map is higher than for the genetic map independent methodologies known as single marker analyses. Close examination of these reports reveals that the two marker approaches are more powerful than single marker analyses only in certain cases. Simulation studies are a commonly used tool to determine the behavior of test statistics under known conditions. We conducted a simulation study to assess the general behavior of an intersection test and a two marker test under a variety of conditions. The study was designed to reveal whether two marker tests are always more powerful than intersection tests, or whether there are cases when an intersection test may outperform the two marker approach. We present a reanalysis of a data set from a QTL study of ovariole number in Drosophila melanogaster. RESULTS: Our simulation study results show that there are situations where the single marker intersection test equals or outperforms the two marker test. The intersection test and the two marker test identify overlapping regions in the reanalysis of the Drosophila melanogaster data. The region identified is consistent with a regression based interval mapping analysis. CONCLUSION: We find that the intersection test is appropriate for analysis of QTL data. This approach has the advantage of simplicity and for certain situations supplies equivalent or more powerful results than a comparable two marker test
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