VLT/NACO infrared adaptive optics images of small scale structures in OMC1

International audienceNear-infrared observations of line emission from excited H 2 and in the continuum are reported in the direction of the Orion molecular cloud OMC1 , using the European Southern Observatory Very Large Telescope UT4 , equipped with the NAOS adaptive optics system on the CONICA infrared array camera. Spatial resolution has been achieved at close to the diffraction limit of the telescope (0. 08 −0. 12) and images show a wealth of morphological detail. Structure is not fractal but shows two preferred scale sizes of 2. (1100 AU) and 1. 2 (540 AU) , where the larger scale may be associated with star formation. Key words. ISM : individual objects : OMC1 – ISM : circumstellar matter – ISM : kinematics and dynamics – ISM : molecules – infrared : IS

The Focused Ultrasound Myoma Outcome Study (FUMOS); a retrospective cohort study on long-term outcomes of MR-HIFU therapy

Objectives: Since 2004, uterine fibroids have been treated with MR-HIFU, but there are persevering doubts on long-term efficacy to date. In the Focused Ultrasound Myoma Outcome Study (FUMOS), we evaluated long-term outcomes after MR-HIFU therapy, primarily to assess the reintervention rate. Methods: Data was retrospectively collected from 123 patients treated with MR-HIFU at our hospital from 2010 to 2017. Follow-up duration and baseline (MRI) characteristics were retrieved from medical records. Treatment failures, adverse events, and the nonperfused volume percentage (NPV%) were determined. Patients received a questionnaire about reinterventions, recovery time, satisfaction, and pregnancy outcomes. Restrictive treatment protocols were compared with unrestrictive (aiming for complete ablation) treatments. Subgroups were analyzed based on the achieved NPV < 50 or ≥ 50%. Results: Treatment failures occurred in 12.1% and the number of adverse events was 13.7%. Implementation of an unrestrictive treatment protocol significantly (p = 0.006) increased the mean NPV% from 37.4% [24.3–53.0] to 57.4% [33.5–76.5]. At 63.5 ± 29.0 months follow-up, the overall reintervention rate was 33.3% (n = 87). All reinterventions were performed within 34 months follow-up, but within 21 months in the unrestrictive group. The reintervention rate significantly (p = 0.002) decreased from 48.8% in the restrictive group (n = 43; follow-up 87.5 ± 7.3 months) to 18.2% in the unrestrictive group (n = 44; follow-up 40.0 ± 22.1 months). The median recovery time was 2.0 [1.0–7.0] days. Treatment satisfaction rate was 72.4% and 4/11 women completed family planning after MR-HIFU. Conclusions: The unrestrictive treatment protocol significantly increased the NPV%. Unrestrictive MR-HIFU treatments led to acceptable reintervention rates comparable to other reimbursed uterine-sparing treatments, and no reinterventions were reported beyond 21 months follow-up. Key Points: • All reinterventions were performe

ZFP36 family members regulate the pro-inflammatory features of psoriatic dermal fibroblasts

Dermal fibroblasts are strategically positioned underneath the basal epidermis layer to support keratinocyte proliferation and extracellular matrix production. In inflammatory conditions, these fibroblasts produce cytokines and chemokines that promote the chemoattraction of immune cells into the dermis and the hyperplasia of the epidermis, two characteristic hallmarks of psoriasis. However, how dermal fibroblasts specifically contribute to psoriasis development remains largely uncharacterized. In this study, we investigated through which cytokines and signaling pathways dermal fibroblasts contribute to the inflammatory features of psoriatic skin. We show that dermal fibroblasts from lesional psoriatic skin are important producers of inflammatory mediators, including IL-6, CXCL8, and CXCL2. This increased cytokine production was found to be regulated by ZFP36 family members ZFP36, ZFP36L1, and ZFP36L2, RNA-binding proteins with mRNA-degrading properties. In addition, the expression of ZFP36 family proteins was found to be reduced in chronic inflammatory conditions that mimic psoriatic lesional skin. Collectively, these results indicate that dermal fibroblasts are important producers of cytokines in psoriatic skin and that reduced expression of ZFP36 members in psoriasis dermal fibroblasts contributes to their inflammatory phenotype

Projet 'Test NDM' : Rapport de synthèse et perspectives

Ce dossier a pour objet de dresser le bilan et les perspectives offertes par le test du logiciel Natural Document Management, dans le cadre des besoins de l'INIST dans le domaine de la Recherche Documentaire . Rappelons que le test, auquel ont participé principalement S. GRESILLAUD et L.MARLOT pour le groupe Utilisateurs , M.VIARD et C.MATOS pour le groupe Réalisateurs, s'est déroulé selon un protocole précis et détaillé dans les différents comptes-rendus d'avancement du 25 Septembre au 9 Novembre 1990. Cette synthèse finale a pour but de dresser un bilan exhaustif sur les capacités fonctionnelles de NDM à répondre aux objectifs définis; elle se propose également de détailler et de quantifier les coûts en charge de développement et en ressources matérielles nécessaires à l'implantation réelle des applications. Dans la plupart de nos analyses, nous distinguerons 2 aspects du Projet, à savoir 'La Base en Ligne' et 'La Revue de Sommaires', pour des raisons tenant non seulement à leur nature qu'aux moyens utilisés pour leur réalisation

De vertaling en implementatie van een evidence-based interventie Success for All voor de Nederlandse situatie

De taalproblematiek van de autochtone achterstands leerling blijft een hardnekkig fenomeen. De achterstand van dit type leerling is sinds 1994 niet kleiner geworden. Vanaf 2002 is er zelfs een daling in het prestatieniveau van dit type leerling te ontdekken (Ledoux, Roeleveld, Driessen, Cuppen, & Meijer, 2011). In de wens hier verandering in te brengen, is gekeken naar internationale effectieve programma’s die positieve effecten sorteren bij (zowel allochtone als autochtone) achterstandsleerlingen. Success for All (SfA), een van oorsprong Amerikaans schoolbreed programma dat is ontwikkeld om achterstandsproblematiek te bestrijden, heeft middels een Randomized Controlled Trial aangetoond dat leerlingen in de SfA-scholen ongeveer een half jaar hoger presteerden op verschillende leestoetsen dan vergelijkbare leerlingen in de controlegroep (Borman et al., 2007). Binnen SfA is er veel aandacht voor de interactie tussen ouders, leerkrachten en school. In deze studie zullen de onderdelen en werkwijzen uit het SfA-programma worden besproken. De ervaringen van ouders in een kleinschalige pilot zullen worden gebruikt om de implementatie en bijbehorende knelpunten in de vertaling naar de Nederlandse situatie te illustreren

Pulse plating of Ni-W alloys from model electrolytes

Pulse plating of nickel-tungsten alloys has been studied from two citrate ammonia based model electrolytes containing either an excess of nickel or an excess of tungsten. The alloy composition and current efficiency were determined for pulse periods ranging from 1 ms to 50 s at a constant duty cycle of 0.4. Deposits were analysed by X-ray fluorescence and by gravimetry. In the nickel rich electrolyte the rate of co-deposition of tungsten was found to be controlled by mass transport as previously observed with Ni-Mo alloys. In the tungsten rich electrolyte the tungsten concentration in the deposited alloys was the highest at short pulse periods. This suggests that the deposition rate of tungsten was affected by the rate of transport of nickel which is the highest at short times. As the pulse on time exceeded the transition time for nickel the current efficiency for alloy deposition dropped owing to hydrogen formation

Profiles of plasma gonadotropin and 17β-estradiol in the common carp, Cyprinus carpio L., as related to spawning induced by hypophysation or LH-RH treatment

International audiencePlasma gonadotropin (GTH) and 17β-estradiol (17β-E2 ) levels and oocyte stage were studied in C. carpio after classical hypophysation (two intraperitoneal pituitary injections of 0.3 mg/kg and 2.7 mg/kg at a 12-h interval) or LH-RH treatment (two intracardiac injections of 3μg/kg at a 3-h interval). After the first pituitary injection of LH-RH treatment, GTH increase was followed by a significant increase of 17β-E2 7 h after the injection. The higher GTH levels after the second pituitary injection did not increase that secretion. After classical hypophysation, 50% of the females ovulated. There was no difference between spawning and non-spawning fishes in relation to hormonal parameters. LH-RH treatment only induced a shifting of the nucleus