Ground-based intercomparison of two isoprene measurement techniques

International audienceAn informal intercomparison of two isoprene (C5H8) measurement techniques was carried out during Fall of 1998 at a field site located approximately 3 km west of Boulder, Colorado, USA. A new chemical ionization mass spectrometric technique (CIMS) was compared to a well-established gas chromatographic technique (GC). The CIMS technique utilized benzene cation chemistry to ionize isoprene. The isoprene levels measured by the CIMS were often larger than those obtained with the GC. The results indicate that the CIMS technique suffered from an anthropogenic interference associated with air masses from the Denver, CO metropolitan area as well as an additional interference occurring in clean conditions. However, the CIMS technique is also demonstrated to be sensitive and fast. Especially after introduction of a tandem mass spectrometric technique, it is therefore a candidate for isoprene measurements in remote environments near isoprene sources

Status of the emittance transfer experiment emtex

In order to improve the injection efficiency of the round UNILAC heavy ion beam into the asymmetric acceptance of the SIS18 it would be of great advantage to decreasethe horizontal emittance by a so called emittance transferto the vertical plane. In this contribution the present statusof the emittance transfer experiment EMTEX at GSI will be reported. A short introduction about the theoretical background of the technique will be given, while the mainpart is dedicated to the practical solutions setting up a testbeam line at GSI. Finally, the results of a first commissioning beam time will be presented. The scheduled beam time to apply the emittance transfer technique foreseen in spring 2014 had to be shifted to calendar week 26 in 2014, just after this conference as some components have not been delivered in time by the contractor. The results and comparison to the theoretical predictions you may find in later publications

CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity.

Intratumoral regulatory T cell (Treg) abundance associates with diminished anti-tumor immunity and poor prognosis in human cancers. Recent work demonstrates that CD25, the high affinity receptor subunit for IL-2, is a selective target for Treg depletion in mouse and human malignancies; however, anti-human CD25 antibodies have failed to deliver clinical responses against solid tumors due to bystander IL-2 receptor signaling blockade on effector T cells, which limits their anti-tumor activity. Here we demonstrate potent single-agent activity of anti-CD25 antibodies optimized to deplete Tregs whilst preserving IL-2-STAT5 signaling on effector T cells, and demonstrate synergy with immune checkpoint blockade in vivo. Pre-clinical evaluation of an anti-human CD25 (RG6292) antibody with equivalent features demonstrates, in both non-human primates and humanized mouse models, efficient Treg depletion with no overt immune-related toxicities. Our data supports the clinical development of RG6292 and evaluation of novel combination therapies incorporating non-IL-2 blocking anti-CD25 antibodies in clinical studies

High Pressure Effects on Superconductivity

The review is devoted to a discussion of the effects of high pressure imposed on superconducting materials. Low-temperature superconductors, high-temperature superconducting cuprates, and some unconventional superconducting compounds are investigated. Experimental as well as theoretical results regarding the pressure effects on Tc and other interesting properties are summarized.Comment: To be published in: "Frontiers in Superconducting Materials", Edt. A. Narlikar, Springer Verla

Arachnoid clearance of red blood cells

Labelled red blood cells were instilled intraventricularly in groups of dogs and monkeys for evaluation of transfer to the vascular compartment. Blood levels were minimal (5% of the original material) with low-pressure infusions. A large movement (above 25%) of the type originally described by Simmonds occurred with high-pressure intraventricular infusions, cisternal injections, or after the induction of intracranial hypertension. Large amounts of the label were released after cell lysis and accumulated in various tissues. Five to ten per cent of the instilled material was absorbed by the nasal lymphatic route in the dog and a significant local loss of red cells occured after posterior cisternal punctures. Simulated whole blood was useful in demonstrating arachnoid retention. Ventriculospinal washouts aided in the elimination of tagged cells only in the first 24 hours. Thereafter, the yield was small and the fluid requirement was unusually high