Comparison of auctions and alternative policy options for RES-E support

This is the final version of the report. Available from AURES via the DOI in this record.This report summarises the findings of Task 6.2 of the AURES project. It intends to compare auctions with alternative policy instruments and examines under which circumstances auctions may be superior and inferior to achieve intended policy targets. Among an abundant list of potential policy drivers, which may affect an instrument’s effectiveness, its efficiency or further success criteria, the basis for the present analysis is the factor risk. It is demonstrated that risk constitutes an important factor as it may have decisive effects on societal welfare and thus may affect the decision-making of policy makers. Given a degree of uncertainty regarding the marginal costs and the marginal benefits of renewable support, particularly the choice between price and quantity-based instruments may yield different welfare effects. Both instruments expose policy makers to a risk of setting inefficient investment incentives. However, while price instruments may reduce the risk of welfare losses given a relatively steep marginal cost and a comparably flat marginal benefit curve, a quantity scheme may be superior if the relation between the two curves is vice versa. Building on this insight, our analysis reveals that the incentives for the use of policy instruments to support the deployment of RES are both country and technology specific. In general, it appears that the incentive to employ a quantity-based mean such as an auction is larger when the natural resources of the technology that is to be supported are abundant and if that technology is rather well developed. Moreover, since within a country the market and natural conditions of the different RES technologies and hence their supply costs may vary considerably, our findings provide an argument against a technology-neutral support.EU Horizon 2020 program, grant number 64617

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

The large chromosomal deletions frequently observed in cancer genomes are often thought to arise as a "two-hit" mechanismin the process of tumor-suppressor gene (TSG) inactivation. Using a murine model system of hepatocellular carcinoma (HCC) and in vivo RNAi, we test an alternative hypothesis, that such deletions can arise from selective pressure to attenuate the activity of multiple genes. By targeting the mouse orthologs of genes frequently deleted on human 8p22 and adjacent regions, which are lost in approximately half of several other major epithelial cancers, we provide evidence suggesting that multiple genes on chromosome 8p can cooperatively inhibit tumorigenesis in mice, and that their cosuppression can synergistically promote tumor growth. In addition, in human HCC patients, the combined down-regulation of functionally validated 8p TSGs is associated with poor survival, in contrast to the down-regulation of any individual gene. Our data imply that large cancer-associated deletions can produce phenotypes distinct from those arising through loss of a single TSG, and as such should be considered and studied as distinct mutational events

An evolving risk perspective for policy instrument choice in sustainability transitions

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.We develop the concept of evolving risk to demonstrate that the optimal policy choice between price and quantity instruments may change over time. Drawing from system innovation, evolutionary concepts and modern financial and transaction cost economics, we analyze dynamic cost and welfare impacts of instrument choice under uncertainty. In early market deployment of niche technologies, economic and system-innovation arguments suggest price instruments can stabilize revenues and decrease market risks for investors. This accelerates deployment without necessarily compromising economic efficiency. Protective policies that work well for niche technologies should, however, be used cautiously during market upscaling and diffusion, due to the changing nature of risks. We use theoretic arguments and a case to demonstrate that a gradual shift towards quantity control may become preferable for welfare maximization under certain circumstances. Solar photovoltaics in Germany serves as illustrative case, where auctions (a form of quantity control) succeeded feed-in tariffs (a price instrument).Danish Council for Strategic ResearchEU Horizon 202

Scintigraphic features of Morquio's syndrome: a case report

<p>Abstract</p> <p>Introduction</p> <p>To the best of our knowledge, we present for the first time the bone scintigraphy findings of a patient with Morquio's syndrome.</p> <p>Case presentation</p> <p>A 46-year-old Caucasian man with Morquio's syndrome presented with lower back pain six weeks after a left total hip replacement. A whole body bone scan demonstrated an anthropomorphic skeletal pattern consistent with a mucopolysaccharide storage disease, thereby showing the cause of the patient's pain.</p> <p>Conclusions</p> <p>To the best of our knowledge, the bone scintigraphy findings of a case of Morquio's syndrome have never before been published. We present our case report to add to the knowledge we have of this rare disease.</p

Comparison of Feed-In Tariffs and Tenders to Remunerate Solar Power Generation

This paper analyzes the trade-offs for using feed-in tariffs or tenders to remunerate different scales of solar photovoltaics (PV) projects. In recent years, European countries increasingly combined feed-in tariffs for small renewables systems with tenders for large installations. This study develops an analytic framework to quantify deployment effectiveness of responsive feed-in tariff adjustment mechanisms across project scales and to compare specific cost effectiveness factors of feed-in tariffs and tenders for PV plants with their dynamic cost trends. To assess deployment effectiveness, an analytic model is used to simulate installations and feed-in tariffs for different project sizes. Then semi-structured interviews with German and French project developers are conducted to identify additional factors to be considered for a comparison of feed-in tariffs and tenders, and to explore how different remuneration schemes impact cost of capital and transaction costs. The paper finally discusses the relative merits of feed-in tariffs and tenders

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

One-year survival rates for newly diagnosed hepatocellular carcinoma (HCC) are <50%, and unresectable HCC carries a dismal prognosis owing to its aggressiveness and the undruggable nature of its main genetic drivers. By screening a custom library of shRNAs directed toward known drug targets in a genetically defined Myc-driven HCC model, we identified cyclin-dependent kinase 9 (Cdk9) as required for disease maintenance. Pharmacological or shRNA-mediated CDK9 inhibition led to robust anti-tumor effects that correlated with MYC expression levels and depended on the role that both CDK9 and MYC exert in transcription elongation. Our results establish CDK9 inhibition as a therapeutic strategy for MYC-overexpressing liver tumors and highlight the relevance of transcription elongation in the addiction of cancer cells to MYC. © 2014 Huang et al