Investigación aplicada en personas de la tercera edad en la ZMG

Trabajo de obtención de grado en el que se presenta el modelo de negocio para una plataforma web interactiva que sirva para que las personas de la tercera edad tengan en un solo sitio a los oferentes de productos, servicios y actividades que sean de su interés. El desarrollo de esta plataforma fue el resultado de una investigación aplicada a personas de la tercera edad en la zona metropolitana de Guadalajara

Gonadal Hormones Rapidly Enhance Spatial Memory and Increase Hippocampal Spine Density in Male Rats

17β-estradiol (E(2)) rapidly, within minutes, activates behaviors and cognition by binding to membrane estrogen receptors, activating cell signaling cascades and increasing dendritic spines. In female rodents, E(2) enhances spatial memory within 2–4 hours, and spine density is increased in the CA1 area of the hippocampus within 30–60 minutes. Although chronic gonadal hormone treatments in male rats alter cognition and spines/spine synapses and acute hormone effects occur in hippocampal slices, effects of acute, in vivo hormone administration in males are unknown. Therefore, we assessed rapid effects of E(2) (20 μg/kg) and testosterone (T) (750 μg/kg) on spatial memory using the object placement task and on hippocampal spine density using Golgi impregnation. Orchidectomized rats received hormones immediately after the training trial and were tested for retention 2 hours later. Vehicle-injected orchidectomized males spent equal time exploring objects in the old and new locations, but E(2-) or T-treated subjects spent more time exploring objects at the new location, suggesting enhanced memory. Both hormones also increased spine density in CA1, but not the dentate gyrus, by 20%–40% at 30 minutes and 2 hours after injections. This report is the first, to our knowledge, to show E(2) and T enhancements of memory and spine density within such a short time frame in male rats

Reference Model for Improving the Process of Enterprise Software Product in the Ecuasis Company

This research work arose to improve the process of enterprise software products for the creation of software companies, through the development of a reference model based on lean startup proposed methodologies to the effect of selective and comparative study of the main methodologies of the entrepreneurship, the methodology to identify that best suits our purpose to generate the proposed model. Finally, generates and implements the proposed model and check the validity by applying a practical case study

Development of a Model for Quality Process Stage Development Software Applied Unit Systems UTMACH

In the present investigation discloses some models or standards focused on system development process. Pretending to give a solution to the user dissatisfaction that causes no profiling to develop quality system. And with reference to the systems unit of the Technical University of Machala and under the investigative process that took place it was detected that there is no order of development in the Unit, the various schedules that are performed many times outside the scope of work team. Due to this circumstance and aims these preliminary detected based on a comparative analysis of the various models or standards applied quality system to create a working environment that allows Systems Unit improve the system development process. Forming itself the quality model system that will engage the Systems Unit

2/3D imaging based on photonics-enabled multi-band MIMO radar system

Photonics-enabled coherent MIMO radars have been numerically investigated to evaluate the benefits of coherence and multi-band operation in 2/3D imaging

Estudo morfoanatômico comparativo entre a poaia (Psychotria ipecacuanha (Brot.) Stokes - Rubiaceae) obtida da região Amazônica (habitat original) e proveniente de processo biotecnológico submetida a diferentes tratamentos de interceptação da radiação solar.

A poaia ou ipeca (Psychotria ipecacuanha (Brot.) Stokes.-Rubiaceae) apesar de seu valor farmacológico e sócio-econômico é cada vez menos freqüente no seu habitat. O objetivo deste trabalho foi realizar o estudo comparativo dos aspectos morfoanatômicos entre a espécie originária da Amazônia Brasileira e a obtida in vitro submetidas a diferentes tratamentos de interceptação de radiação solar, visando, desta forma, dar suporte a estudos com fins de preservação, cultivo, validação farmacognóstica/farmacopéica e ampliar o conhecimento biotecnológico desta espécie. A espécie nativa foi obtida de fragmento de mata (fase vegetativa) e empregada para micropropagação através do cultivo in vitro de fragmentos de segmentos internodais sobre meio de cultivo Murashige & Skoog com o regulador de crescimento BAP (2,0 mg/l de meio). Obtiveram-se plântulas que foram transferidas para casa de vegetação por 2 anos sob dois tipos de ambiente e três diferentes tratamentos de interceptação da radiação solar. Foi feito o estudo morfoanatômico, analisado estatisticamente. Verifica-se que as plantas originadas por processo biotecnológico e submetidas aos diferentes tratamentos apresentam morfologia semelhante à planta nativa, no entanto constatou-se um maior número de raízes secundárias, não há diferença significativa entre larguras e comprimentos de folhas, comprimento de raízes, estípulas, peso de raízes e rizomas. Mas, observou-se diferença estatística no comprimento do caule em relação à nativa

Mycosphaerella leaf spot diseases of bananas: present status and outlook: Proceedings of the 2nd international workshop on Mycosphaerella leaf spot diseases held in San José, Costa Rica, 20-23 may 2002

Thriteen years after the 1st international workshop on Sigatoka diseases of Banana held in San José, Costa Rica, in March 1989, the present proceedings offer an overview of the current situation regarding Mycosphaerella leaf spot diseases at the global level

Engineering rotating apical-out airway organoid for assessing respiratory cilia motility

Motile cilia project from the airway apical surface and directly interface with inhaled external environment. Owing to cilia\u27s nanoscale dimension and high beating frequency, quantitative assessment of their motility remains a sophisticated task. Here we described a robust approach for reproducible engineering of apical-out airway organoid (AOAO) from a defined number of cells. Propelled by exterior-facing cilia beating, the mature AOAO exhibited stable rotational motion when surrounded by Matrigel. We developed a computational framework leveraging computer vision algorithms to quantify AOAO rotation and correlated it with the direct measurement of cilia motility. We further established the feasibility of using AOAO rotation to recapitulate and measure defective cilia motility caused by chemotherapy-induced toxicity and by CCDC39 mutations in cells from patients with primary ciliary dyskinesia. We expect our rotating AOAO model and the associated computational pipeline to offer a generalizable framework to expedite the modeling of and therapeutic development for genetic and environmental ciliopathies

Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females

Most studies on ketosis have focused on short-term effects, male athletes, or weight loss. Hereby, we studied the effects of short-term ketosis suppression in healthy women on long-standing ketosis. Ten lean (BMI 20.5 ± 1.4), metabolically healthy, pre-menopausal women (age 32.3 ± 8.9) maintaining nutritional ketosis (NK) for > 1 year (3.9 years ± 2.3) underwent three 21-day phases: nutritional ketosis (NK; P1), suppressed ketosis (SuK; P2), and returned to NK (P3). Adherence to each phase was confirmed with daily capillary D-beta-hydroxybutyrate (BHB) tests (P1 = 1.9 ± 0.7; P2 = 0.1 ± 0.1; and P3 = 1.9 ± 0.6 mmol/L). Ageing biomarkers and anthropometrics were evaluated at the end of each phase. Ketosis suppression significantly increased: insulin, 1.78-fold from 33.60 (± 8.63) to 59.80 (± 14.69) mmol/L (p = 0.0002); IGF1, 1.83-fold from 149.30 (± 32.96) to 273.40 (± 85.66) µg/L (p = 0.0045); glucose, 1.17-fold from 78.6 (± 9.5) to 92.2 (± 10.6) mg/dL (p = 0.0088); respiratory quotient (RQ), 1.09-fold 0.66 (± 0.05) to 0.72 (± 0.06; p = 0.0427); and PAI-1, 13.34 (± 6.85) to 16.69 (± 6.26) ng/mL (p = 0.0428). VEGF, EGF, and monocyte chemotactic protein also significantly increased, indicating a pro-inflammatory shift. Sustained ketosis showed no adverse health effects, and may mitigate hyperinsulinemia without impairing metabolic flexibility in metabolically healthy women

Central Bank Independence: Monetary Policies in Selected Jurisdictions (III)

A sufficient and appropriate degree of central bank independence is widely acknowledged to be necessary for the goal of achieving price stability. However, despite the levels of independence claimed to be enjoyed by several central banks, recent events indicate shifts in focus of monetary policy objectives by various prominent central banks. The impact of political and government influences on central banks' monetary policies has been evidenced from the recent financial crisis – and in several jurisdictions. Many central banks have adjusted monetary policies having been influenced by political pressures which have built up as a result of the recent crises. However such lack of absolute independence (from political spheres) could prove symbiotic in the sense that, despite the need for a certain degree of independence from political interference, certain events which are capable of devastating consequences, namely, a drastic disruption of the system's financial stability, need to be responded to as quickly and promptly as possible. Is it possible for a central bank with absolute independence to operate effectively – particularly given the close links between many central banks and their Treasury in several countries? It may be inferred that central banks' crucial roles in establishing a macro prudential framework provide the key to bridging the gap between macro economic policy and the regulation of individual financial institutions. This however, on its own, is insufficient – close collaboration and effective information sharing between central banks and regulatory authorities is paramount