Neuropsychological profile of patients with normal pressure hydrocephalus and Alzheimer's disease

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Neuropsychological profile of patients with normal pressure hydrocephalus and Alzheimer's disease

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

A three-dimensional model of primary bovine endometrium using an electrospun scaffold

Endometrial stromal and epithelial cell function is typically studied in vitro using standard two-dimensional monocultures, but these cultures fail to reflect the complex three-dimensional (3D) architecture of tissue. A 3D model of bovine endometrium that reflects the architectural arrangement of in vivo tissue would beneficially assist the study of tissue function. An electrospun polyglycolide (PGA) scaffold was selected to grow a 3D model of primary bovine endometrial epithelial and stromal cells, that reflects the architecture of the endometrium for the study of pathophysiology. Electrospun scaffolds were seeded with stromal and epithelial cells, and growth was assessed using histological techniques. Prostaglandin E2 and prostaglandin F2α responsiveness of endometrial scaffold constructs was tested using oxytocin plus arachidonic acid (OT + AA) or lipopolysaccharide (LPS). Stromal and epithelial cells growing on the electrospun scaffold had an architectural arrangement that mimicked whole tissue, deposited fibronectin, had appropriate expression of vimentin and cytokeratin and were responsive to OT + AA and LPS, as measured by prostaglandin accumulation. In conclusion, a functional 3D model of stromal and epithelial cells was developed using a PGA electrospun scaffold which may be used to study endometrial pathophysiology

Measurement and rapid assessment of indoor air quality at mass gathering events to assess ventilation performance and reduce aerosol transmission of SARS-CoV-2

To assess risk factors for COVID-19 transmission and address the closure of mass gathering events since March 2020, the UK Government ran the Events Research Programme (ERP), following which it reopened live events in sports, music, and culture in July 2021. We report the rapid post-occupancy evaluation of Indoor Air Quality (IAQ) and associated long-range airborne transmission risk conducted in the Environmental Study of the ERP. Ten large venues around the UK were monitored with CO2 sensors at a high spatial and temporal resolution during 90 events. An IAQ Index based on CO2 concentration was developed, and all monitored spaces were classified in bands from A to G based on their average and maximum CO2 concentrations from all events. High resolution monitoring and the IAQ Index depicted the overall state of ventilation at live events, and allowed identification of issues with ventilation effectiveness and distribution, and of spaces with poor ventilation and the settings in which long-range airborne transmission risk may be increased. In numerous settings, CO2 concentrations were found to follow patterns relating to event management and specific occupancy of spaces around the venues. Good ventilation was observed in 90% of spaces monitored for given occupancies. Practical applications: High-resolution monitoring of indoor CO2 concentrations is necessary to detect the spatial variation of indoor air quality (IAQ) in large mass gathering event venues. The paper summarises COVID-19 ventilation guidance for buildings and defines a methodology for measurement and rapid assessment of IAQ during occupancy at live events that can be implemented by venue managers. Comparisons of the CO2 concentrations measured during the events identified the spaces at high risk of long-range transmission of airborne pathogens. Building operators should be mindful of the ventilation strategies used relative to the total occupancy in different spaces and the occupant’s activities

Environmental performance of miscanthus-lime lightweight concrete using life cycle assessment:Application in external wall assemblies

This is the final version. Available from Elsevier via the DOI in this record. In the UK context, miscanthus is a potential alternative perennial crop for the development of bio-based building materials. This paper presents the environmental benefits of using miscanthus shives in lightweight blocks and their potential application in wall assemblies. A systemic life cycle assessment (LCA) is carried out for miscanthus-lime blocks, and the effects of binder type and binder content are discussed. The environmental performance-based analysis reveals that miscanthus blocks can capture 135 kg CO eq/m for an assumed 100-years life period. The impact analysis using the University of Leiden, institute of environmental science (CML) baseline (v4.4) method shows that 75% of the greenhouse gas emissions are attributable to the production of mineral binders. A reduction of binder to aggregate ratio from 2.0 to 1.5 reduces greenhouse gas emissions by 32.9%. The use of 10 wt% mineral additions can potentially stabilise blocks while having little effect on their overall environmental impacts. The environmental profiles of wall systems incorporating miscanthus-lime blocks have been evaluated in this this study. Combining miscanthus blocks with fired clay bricks enables a potential low carbon retrofitting technique for the current stock of residential buildings in the UK. Timber-framed system filled with miscanthus blocks enables a carbon storage of ~97.3 kg CO eq/m , which presents a potential carbon offsetting strategy in new-build dwellings. Consideration should be given to the potential negative impacts related to agricultural activities for the production of miscanthus shives. The largest negative environmental impact was ozone layer depletion, where a relative difference of 12.8% was recorded between miscanthus timber-framed wall and a typical solid wall insulated with mineral wool. It appears that miscanthus-lime composites can substantially improve the environmental profile of wall assemblies and sustainability be applied in existing uninsulated masonry walls or incorporated in timber- framed new-build houses.Engineering and Physical Sciences Research Council (EPSRC)Natural Environment Research Council (NERC)NERC GW4+ Doctoral Training Partnership studentshi

Deliberate termination of life of newborns with spina bifida, a critical reappraisal

Objects: Deliberate termination of life of newborns (involuntary euthanasia) with meningomyelocele (MMC) is practiced openly only in the Netherlands. 'Unbearable and hopeless suffering' is the single most cited criterion for this termination, together with the notion that 'there are no other proper medical means to alleviate this suffering'. In this paper, both (and other) statements are questioned, also by putting them in a broader perspective. Methods: First, a historical overview of the treatment of newborns with MMC is presented, concentrating on the question of selection for treatment. Second, a thorough analysis is made of the criteria used for life termination. Third, a case of a newborn with a very severe MMC is presented as a 'reference case'. Conclusion: 'Unbearable and hopeless suffering' cannot be applied to newborns with MMC. They are not 'terminally ill' and do have 'prospects of a future'. In these end-of-life decisions, 'quality of life judgments' should not be applied. When such a newborn is not treated, modern palliative care always will suffice in eliminating possible discomfort. There is no reason whatsoever for active life-termination of these newborns

Energy dependence and fluctuations of anisotropic flow in Pb-Pb collisions at √sNN=5.02 and 2.76 TeV

Measurements of anisotropic flow coefficients with two- and multi-particle cumulants for inclusive charged particles in Pb-Pb collisions at sNN=5.02 and 2.76 TeV are reported in the pseudorapidity range |η| < 0.8 and transverse momentum 0.2 < pT < 50 GeV/c. The full data sample collected by the ALICE detector in 2015 (2010), corresponding to an integrated luminosity of 12.7 (2.0) μb−1 in the centrality range 0-80%, is analysed. Flow coefficients up to the sixth flow harmonic (v6) are reported and a detailed comparison among results at the two energies is carried out. The pT dependence of anisotropic flow coefficients and its evolution with respect to centrality and harmonic number n are investigated. An approximate power-law scaling of the form vn(pT) ∼ pTn/3 is observed for all flow harmonics at low pT (0.2 < pT < 3 GeV/c). At the same time, the ratios vn/vmn/ m are observed to be essentially independent of pT for most centralities up to about pT = 10 GeV/c. Analysing the differences among higher-order cumulants of elliptic flow (v2), which have different sensitivities to flow fluctuations, a measurement of the standardised skewness of the event-by-event v2 distribution P(v2) is reported and constraints on its higher moments are provided. The Elliptic Power distribution is used to parametrise P(v2), extracting its parameters from fits to cumulants. The measurements are compared to different model predictions in order to discriminate among initial-state models and to constrain the temperature dependence of the shear viscosity to entropy-density ratio.[Figure not available: see fulltext.]

Anisotropic flow of identified particles in Pb-Pb collisions at √sNN=5.02 TeV

The elliptic (v2), triangular (v3), and quadrangular (v4) flow coefficients of π±, K±, p+p ̄,Λ+Λ ̄,KS0, and the φ-meson are measured in Pb-Pb collisions at sNN=5.02 TeV. Results obtained with the scalar product method are reported for the rapidity range |y| < 0.5 as a function of transverse momentum, pT, at different collision centrality intervals between 0–70%, including ultra-central (0–1%) collisions for π±, K±, and p + p ̄. For pT< 3 GeV/c, the flow coefficients exhibit a particle mass dependence. At intermediate transverse momenta (3 < pT < 8–10 GeV/c), particles show an approximate grouping according to their type (i.e., mesons and baryons). The φ-meson v2, which tests both particle mass dependence and type scaling, follows p + p ̄ v2 at low pT and π±v2 at intermediate pT. The evolution of the shape of vn(pT) as a function of centrality and harmonic number n is studied for the various particle species. Flow coefficients of π±, K±, and p + p ̄ for pT < 3 GeV/c are compared to iEBE-VISHNU and MUSIC hydrodynamical calculations coupled to a hadronic cascade model (UrQMD). The iEBE-VISHNU calculations describe the results fairly well for pT < 2.5 GeV/c, while MUSIC calculations reproduce the measurements for pT < 1 GeV/c. A comparison to vn coefficients measured in Pb-Pb collisions at sNN=2.76 TeV is also provided.[Figure not available: see fulltext.]

First polarisation measurement of coherently photoproduced J/ψ in ultra-peripheral Pb–Pb collisions at sNN=5.02 TeV

The first measurement of the polarisation of coherently photoproduced J/ψ mesons in ultra-peripheral Pb–Pb collisions, using data at sNN=5.02 TeV, is presented. The J/ψ meson is measured via its dimuon decay channel in the forward rapidity interval −4.0<−2.5 using the ALICE detector at the CERN LHC. An event sample corresponding to an integrated luminosity of 750 μb−1 ± 5% (syst) is analysed. Hadronic activity is highly suppressed since the interaction is mediated by a photon. The polar and azimuthal angle distributions of the decay muons are measured, and the polarisation parameters λθ, λφ, λθφ are extracted. The analysis is carried out in the helicity frame. The results are found to be consistent with a transversely polarised J/ψ. These values are compared with previous measurements by the H1 and ZEUS experiments. The polarisation parameters of coherent J/ψ photoproduction in Pb–Pb collisions are found to be consistent with the s-channel helicity conservation hypothesis