862 research outputs found
Montana\u27s Constitutional Environmental Quality Provisions: Self-Execution or Self-Delusion?
Montana\u27s Constitutional Environmental Quality Provisions: Self-Execution or Self-Delusion
MEIC v. DEQ: An Inadequate Effort to Address the Meaning of Montana\u27s Constitutional Environmental Provisions
MEIC v. DE
Montana Supreme Court Unnecessarily Misconstrues Takings Law
Montana Supreme Court Unnecessarily Misconstrues Takings La
Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria
A nuclear encoded mitochondrial heat-shock protein hsp60 is required for the assembly into oligomeric complexes of proteins imported into the mitochondrial matrix. hsp60 is a member of the 'chaperonin' class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplast
Metastatic seminoma treated with either single agent carboplatin or cisplatin-based combination chemotherapy: a pooled analysis of two randomised trials
Does a Computer have an Arrow of Time?
In [Sch05a], it is argued that Boltzmann's intuition, that the psychological
arrow of time is necessarily aligned with the thermodynamic arrow, is correct.
Schulman gives an explicit physical mechanism for this connection, based on the
brain being representable as a computer, together with certain thermodynamic
properties of computational processes. [Haw94] presents similar, if briefer,
arguments. The purpose of this paper is to critically examine the support for
the link between thermodynamics and an arrow of time for computers. The
principal arguments put forward by Schulman and Hawking will be shown to fail.
It will be shown that any computational process that can take place in an
entropy increasing universe, can equally take place in an entropy decreasing
universe. This conclusion does not automatically imply a psychological arrow
can run counter to the thermodynamic arrow. Some alternative possible explana-
tions for the alignment of the two arrows will be briefly discussed.Comment: 31 pages, no figures, publication versio
Stochastic Modelling Approach to the Incubation Time of Prionic Diseases
Transmissible spongiform encephalopathies like the bovine spongiform
encephalopathy (BSE) and the Creutzfeldt-Jakob disease (CJD) in humans are
neurodegenerative diseases for which prions are the attributed pathogenic
agents. A widely accepted theory assumes that prion replication is due to a
direct interaction between the pathologic (PrPsc) form and the host encoded
(PrPc) conformation, in a kind of an autocatalytic process. Here we show that
the overall features of the incubation time of prion diseases are readily
obtained if the prion reaction is described by a simple mean-field model. An
analytical expression for the incubation time distribution then follows by
associating the rate constant to a stochastic variable log normally
distributed. The incubation time distribution is then also shown to be log
normal and fits the observed BSE data very well. The basic ideas of the
theoretical model are then incorporated in a cellular automata model. The
computer simulation results yield the correct BSE incubation time distribution
at low densities of the host encoded protein
Intensive induction chemotherapy with C-BOP/BEP for intermediate- and poor-risk metastatic germ cell tumours (EORTC trial 30948)
New chemotherapy regimens are continuously explored in patients with high-risk malignant germ cell tumours (MGCTs). This multicentre phase II trial assessed the efficacy and toxicity of C-BOP/BEP chemotherapy in intermediate and poor prognosis MGCT (IGCCCG criteria). C-BOP/BEP treatment consisted of cycles of cisplatin, vincristine, bleomycin and carboplatin, followed by one cycle of vincristine and bleomycin and three cycles of BEP (bleomycon, etoposide, cisplatin). The trial was designed to demonstrate a 1-year progression-free survival rate of 80%, that is, to exclude a 1-year rate of 70% or less, with a one-sided significance level of 5%. Secondary end points included toxicity, overall survival and the postchemotherapy complete response rate. In total, 16 European hospitals entered 66 eligible patients (intermediate prognosis group: 37; poor prognosis group: 29). A total of 45 patients (68.2%, 95% confidence interval (95% CI): 56.9–79.4%) achieved a complete response (intermediate prognosis: 30; poor prognosis: 15). After a median observation time of 40.4 months (range: 13.7–66.3), the 1-year progression-free survival rate was 81.8% 95% CI: 72.5–91.1%). The 2-year overall survival was 84.5% (95% CI: 75.6–93.3%). In all, 51 patients experienced at least one episode of WHO grade 3/4 leucopenia, and at least one event of grade 3/4 thrombocytopenia occurred in 30 patients. There was no toxic death. With an 82% 1-year progression-free survival and a lower limit of the 95% CI above 70%, the efficacy of C-BOP/BEP is comparable to that of published alternative chemotherapy schedules in high-risk MGCT patients. The treatment's toxicity is manageable in a multicentre setting. In poor prognosis patients, C-BOP/BEP should be compared to standard chemotherapy of four cycles of BEP
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