Comparative Evaluation of Hepatoprotective Activity of Xymedon Preparation Derivatives with Ascorbic Acid and Methionine

© 2017, Springer Science+Business Media, LLC. The main objective of this work was a comparative evaluation of hepatoprotective activity of pyrimidine derivative of the active compound of Xymedon (1-(ß-oxyethyl)-4.6-dimethyl-1.2-dihydro-2-oxopirimidon) and its derivatives with methionine and ascorbic acid. The experiment was conducted on nonlinear white rats of both sexes based on the model of toxic damage inflicted on liver by CCl 4 with prophylactic scheme. The compounds were injected at doses of 1/500 LD 50 (13 mg/kg for Xymedon and 11 mg/kg for its derivatives with ascorbic acid and methionine). The study showed that, out of the three compounds considered, the Xymedon derivative with ascorbic acid had the most prominent hepatoprotective properties, as, given the CCl 4 poisoning, it caused the greatest decrease of liver damage area (by a factor of 3.25 over control) and change of the largest number of biochemical markers towards normalization. The Xymedon derivative with methionine had less prominent hepatoprotective properties than both the derivative with ascorbic acid and Xymedon itself

Minería metálica a cielo abierto

[No abstract available

Angiotensin-receptor neprilysin inhibitor LCZ696; A novel therapy for heart failure

[No abstract available

Comparative Evaluation of Hepatoprotective Activity of Xymedon Preparation Derivatives with Ascorbic Acid and Methionine

© 2017, Springer Science+Business Media, LLC. The main objective of this work was a comparative evaluation of hepatoprotective activity of pyrimidine derivative of the active compound of Xymedon (1-(ß-oxyethyl)-4.6-dimethyl-1.2-dihydro-2-oxopirimidon) and its derivatives with methionine and ascorbic acid. The experiment was conducted on nonlinear white rats of both sexes based on the model of toxic damage inflicted on liver by CCl 4 with prophylactic scheme. The compounds were injected at doses of 1/500 LD 50 (13 mg/kg for Xymedon and 11 mg/kg for its derivatives with ascorbic acid and methionine). The study showed that, out of the three compounds considered, the Xymedon derivative with ascorbic acid had the most prominent hepatoprotective properties, as, given the CCl 4 poisoning, it caused the greatest decrease of liver damage area (by a factor of 3.25 over control) and change of the largest number of biochemical markers towards normalization. The Xymedon derivative with methionine had less prominent hepatoprotective properties than both the derivative with ascorbic acid and Xymedon itself

Hepatoprotective Effect of Inonotus obliquus Melanins: In Vitro and In Vivo Studies

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. The purpose of this study is to identify hepatoprotective properties of melanins from aqueous extracts of Inonotus obliquus distinguished by microwave modes used in extraction in both in vitro and in vivo studies. In vitro tests were used in studies of the effect of Chaga mushroom melanins on the vitality of cells of a normal human hepatocyte line Chang Liver, as well as their hepatoprotective effect and influence on the cell cycle. The hepatoprotective effect was studied in the context of the influence of the toxicant d-galactosamine, at a concentration of 150 mM. The results show that the melanin of the aqueous extract of Chaga, obtained in the process of microwave-assisted extraction at 180 W, at concentrations of 10−5 and 10−3 g/l, displays a hepatoprotective effect, as it increases the vitality of cells under the toxic influence of d-galactosamine by 2–2.5 times. In vivo tests were used in studies of the hepatoprotective properties of the melanin of the aqueous extract of Chaga obtained in the process of microwave-assisted extraction at 180 W on white male Sprague Dawley rats. The melanin was administered to rats for 14 days at a dose of 100 mg/kg. Toxic damage was inflicted on the liver using carbon tetrachloride on days 5 to 12 of administering the melanin; the liver was studied and the blood biochemical parameters were determined on day 15. It was shown that melanin produces a hepatoprotective effect which is expressed in the minimization of liver injury signs such as steatosis, necrosis, fat accumulation, and normalization of the total and unconjugated bilirubin, total protein, serum cholinesterase, and gamma-glutamyl transpeptidase levels

Angiotensin-receptor neprilysin inhibitor LCZ696; a novel therapy for heart failure

[No abstract available