Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1

Massive research efforts are now underway to develop a cure for HIV infection, allowing patients to discontinue lifelong combination antiretroviral therapy (ART). New latency-reversing agents (LRAs) may be able to purge the persistent reservoir of latent virus in resting memory CD4+ T cells, but the degree of reservoir reduction needed for cure remains unknown. Here we use a stochastic model of infection dynamics to estimate the efficacy of LRA needed to prevent viral rebound after ART interruption. We incorporate clinical data to estimate population-level parameter distributions and outcomes. Our findings suggest that approximately 2,000-fold reductions are required to permit a majority of patients to interrupt ART for one year without rebound and that rebound may occur suddenly after multiple years. Greater than 10,000-fold reductions may be required to prevent rebound altogether. Our results predict large variation in rebound times following LRA therapy, which will complicate clinical management. This model provides benchmarks for moving LRAs from the lab to the clinic and can aid in the design and interpretation of clinical trials. These results also apply to other interventions to reduce the latent reservoir and can explain the observed return of viremia after months of apparent cure in recent bone marrow transplant recipients and an immediately-treated neonate.Comment: 8 pages main text (4 figures). In PNAS Early Edition http://www.pnas.org/content/early/2014/08/05/1406663111. Ancillary files: SI, 24 pages SI (7 figures). File .htm opens a browser-based application to calculate rebound times (see SI). Or, the .cdf file can be run with Mathematica. The most up-to-date version of the code is available at http://www.danielrosenbloom.com/reboundtimes

First cosmic shear results from the Canada-France-Hawaii Telescope Wide Synoptic Legacy Survey

We present the first measurements of the weak gravitational lensing signal induced by the large scale mass distribution from data obtained as part of the ongoing Canada-France-Hawaii Telescope Legacy Survey (CFHTLS). The data used in this analysis are from the Wide Synoptic Survey, which aims to image ~170 square degree in five filters. We have analysed ~22 deg2 (31 pointings) of i' data spread over two of the three survey fields. These data are of excellent quality and the results bode well for the remainder of the survey: we do not detect a significant `B'-mode, suggesting that residual systematics are negligible at the current level of accuracy. Assuming a Cold Dark Matter model and marginalising over the Hubble parameter h=[0.6,0.8], the source redshift distribution and systematics, we constrain sigma_8, the amplitude of the matter power spectrum. At a fiducial matter density Omega_m=0.3 we find sigma_8=0.85+-0.06. This estimate is in excellent agreement with previous studies. Combination of our results with those from the Deep component of the CFHTLS enables us to place a constraint on a constant equation of state for the dark energy, based on cosmic shear data alone. We find that w_0<-0.8 at 68% confidence.Comment: Submitted to Ap

States interpolating between number and coherent states and their interaction with atomic systems

Using the eigenvalue definition of binomial states we construct new intermediate number-coherent states which reduce to number and coherent states in two different limits. We reveal the connection of these intermediate states with photon-added coherent states and investigate their non-classical properties and quasi-probability distributions in detail. It is of interest to note that these new states, which interpolate between coherent states and number states, neither of which exhibit squeezing, are nevertheless squeezed states. A scheme to produce these states is proposed. We also study the interaction of these states with atomic systems in the framework of the two-photon Jaynes-Cummings model, and describe the response of the atomic system as it varies between the pure Rabi oscillation and the collapse-revival mode and investigate field observables such as photon number distribution, entropy and the Q-function.Comment: 26 pages, 29 EPS figures, Latex, Accepted for publication in J.Phys.

Metamaterial with polarization and direction insensitive resonant transmission response mimicking electromagnetically induced transparency

We report on a planar metamaterial, the resonant transmission frequency of which does not depend on the polarization and angle of incidence of electromagnetic waves. The resonance results from the excitation of high-Q antisymmetric trapped current mode and shows sharp phase dispersion characteristic to Fano-type resonances of the electromagnetically induced transparency phenomenon

Determining the strange and antistrange quark distributions of the nucleon

The difference between the strange and antistrange quark distributions, \delta s(x)=s(x)-\sbar(x), and the combination of light quark sea and strange quark sea, \Delta (x)=\dbar(x)+\ubar(x)-s(x)-\sbar(x), are originated from non-perturbative processes, and can be calculated using non-perturbative models of the nucleon. We report calculations of $\delta s(x)$ and $\Delta(x)$ using the meson cloud model. Combining our calculations of $\Delta(x)$ with relatively well known light antiquark distributions obtained from global analysis of available experimental data, we estimate the total strange sea distributions of the nucleon.Comment: 4 pages, 3 figures; talk given by F.-G. at QNP0

Spin orbit coupling in bulk ZnO and GaN

Using group theory and Kane-like $\mathbf{k\cdot p}$ model together with the L\"owdining partition method, we derive the expressions of spin-orbit coupling of electrons and holes, including the linear-$k$ Rashba term due to the intrinsic structure inversion asymmetry and the cubic-$k$ Dresselhaus term due to the bulk inversion asymmetry in wurtzite semiconductors. The coefficients of the electron and hole Dresselhaus terms of ZnO and GaN in wurtzite structure and GaN in zinc-blende structure are calculated using the nearest-neighbor $sp^3$ and $sp^3s^\ast$ tight-binding models separately.Comment: 9 pages, 6 figures, to be published in J. Appl. Phy

Reverberation measurement of the inner radius of the dust torus in NGC 4151 during 2008-2013

We investigate the correlation between infrared (JHKL) and optical (B) fluxes of the variable nucleus of the Seyfert galaxy NGC 4151 using partially published data for the last 6 years (2008-2013.). Here we are using the same data as in Oknyansky et al. (2014), but include also optical (B) data from Guo et al. We find that the lag of flux in all the infrared bands is the same, 40 +- 6 days, to within the measurement accuracy. Variability in the J and K bands is not quite simultaneous, perhaps due to the differing contributions of the accretion disk in these bands. The lag found for the K band compared with the B band is not significantly different from earlier values obtained for the period 2000-2007. However, finding approximately the same lags in all IR bands for 2008-2013 differs from previous results at earlier epochs when the lag increased with increasing wavelength. Examples of almost the same lag in different IR bands are known for some other active nuclei. In the case of NGC 4151 it appears that the relative lags between the IR bands may be different in different years. The available data, unfortunately, do not allow us to investigate a possible change in the lags during the test interval. We discuss our results in the framework of the standard model where the variable infrared radiation is mainly due to thermal re-emission from the part of the dusty torus closest to the central source. There is also a contribution of some IR emission from the accretion disk, and this contribution increases with decreasing wavelength. Some cosmological applications of obtained results are discussed.Comment: 3 pages, 2 figures, 14-th Odessa International Astronomical Gamow Conference-School Astronomy and beyond: Astrophysics, Cosmology and Gravitation, Cosmomicrophysics, Radio-astronomy and Astrobiolog

Topological Insulators with Inversion Symmetry

Topological insulators are materials with a bulk excitation gap generated by the spin orbit interaction, and which are different from conventional insulators. This distinction is characterized by Z_2 topological invariants, which characterize the groundstate. In two dimensions there is a single Z_2 invariant which distinguishes the ordinary insulator from the quantum spin Hall phase. In three dimensions there are four Z_2 invariants, which distinguish the ordinary insulator from "weak" and "strong" topological insulators. These phases are characterized by the presence of gapless surface (or edge) states. In the 2D quantum spin Hall phase and the 3D strong topological insulator these states are robust and are insensitive to weak disorder and interactions. In this paper we show that the presence of inversion symmetry greatly simplifies the problem of evaluating the Z_2 invariants. We show that the invariants can be determined from the knowledge of the parity of the occupied Bloch wavefunctions at the time reversal invariant points in the Brillouin zone. Using this approach, we predict a number of specific materials are strong topological insulators, including the semiconducting alloy Bi_{1-x} Sb_x as well as \alpha-Sn and HgTe under uniaxial strain. This paper also includes an expanded discussion of our formulation of the topological insulators in both two and three dimensions, as well as implications for experiments.Comment: 16 pages, 7 figures; published versio