STM Studies of Synthetic Peptide Monolayers

We have used scanning probe microscopy to investigate self-assembled monolayers of chemically synthesized peptides. We find that the peptides form a dense uniform monolayer, above which is found a sparse additional layer. Using scanning tunneling microscopy, submolecular resolution can be obtained, revealing the alpha helices which constitute the peptide. The nature of the images is not significantly affected by the incorporation of redox cofactors (hemes) in the peptides.Comment: 4 pages, 3 figures (4 gifs); to appear in the Proceedings of the XIIth Int. Winterschool on Electronic Properties of Novel Materials "Molecular Nanostructures", Kirchberg/Tyrol, Febr. 199

Nurse telephone triage for same day appointments in general practice: multiple interrupted time series trial of effect on workload and costs

OBJECTIVE: To compare the workloads of general practitioners and nurses and costs of patient care for nurse telephone triage and standard management of requests for same day appointments in routine primary care. DESIGN: Multiple interrupted time series using sequential introduction of experimental triage system in different sites with repeated measures taken one week in every month for 12 months. SETTING: Three primary care sites in York. Participants: 4685 patients: 1233 in standard management, 3452 in the triage system. All patients requesting same day appointments during study weeks were included in the trial. MAIN OUTCOME MEASURES: Type of consultation (telephone, appointment, or visit), time taken for consultation, presenting complaints, use of services during the month after same day contact, and costs of drugs and same day, follow up, and emergency care. RESULTS: The triage system reduced appointments with general practitioner by 29-44%. Compared with standard management, the triage system had a relative risk (95% confidence interval) of 0.85 (0.72 to 1.00) for home visits, 2.41 (2.08 to 2.80) for telephone care, and 3.79 (3.21 to 4.48) for nurse care. Mean overall time in the triage system was 1.70 minutes longer, but mean general practitioner time was reduced by 2.45 minutes. Routine appointments and nursing time increased, as did out of hours and accident and emergency attendance. Costs did not differ significantly between standard management and triage: mean difference £1.48 more per patient for triage (95% confidence interval -0.19 to 3.15). CONCLUSIONS: Triage reduced the number of same day appointments with general practitioners but resulted in busier routine surgeries, increased nursing time, and a small but significant increase in out of hours and accident and emergency attendance. Consequently, triage does not reduce overall costs per patient for managing same day appointments

NIHAO XX: The impact of the star formation threshold on the cusp-core transformation of cold dark matter haloes

We use cosmological hydrodynamical galaxy formation simulations from the NIHAO project to investigate the impact of the threshold for star formation on the response of the dark matter (DM) halo to baryonic processes. The fiducial NIHAO threshold, $n=10\, {\rm cm}^{-3}$, results in strong expansion of the DM halo in galaxies with stellar masses in the range $10^{7.5} < M_{star} < 10^{9.5} M_{\odot}$. We find that lower thresholds such as $n=0.1$ (as employed by the EAGLE/APOSTLE and Illustris/AURIGA projects) do not result in significant halo expansion at any mass scale. Halo expansion driven by supernova feedback requires significant fluctuations in the local gas fraction on sub-dynamical times (i.e., < 50 Myr at galaxy half-light radii), which are themselves caused by variability in the star formation rate. At one per cent of the virial radius, simulations with $n=10$ have gas fractions of $\simeq 0.2$ and variations of $\simeq 0.1$, while $n=0.1$ simulations have order of magnitude lower gas fractions and hence do not expand the halo. The observed DM circular velocities of nearby dwarf galaxies are inconsistent with CDM simulations with $n=0.1$ and $n=1$, but in reasonable agreement with $n=10$. Star formation rates are more variable for higher $n$, lower galaxy masses, and when star formation is measured on shorter time scales. For example, simulations with $n=10$ have up to 0.4 dex higher scatter in specific star formation rates than simulations with $n=0.1$. Thus observationally constraining the sub-grid model for star formation, and hence the nature of DM, should be possible in the near future.Comment: 18 pages, 13 figures, accepted to MNRA

The edge of galaxy formation III: The effects of warm dark matter on Milky Way satellites and field dwarfs

In this third paper of the series, we investigate the effects of warm dark matter with a particle mass of $m_\mathrm{WDM}=3\,\mathrm{keV}$ on the smallest galaxies in our Universe. We present a sample of 21 hydrodynamical cosmological simulations of dwarf galaxies and 20 simulations of satellite-host galaxy interaction that we performed both in a Cold Dark Matter (CDM) and Warm Dark Matter (WDM) scenario. In the WDM simulations, we observe a higher critical mass for the onset of star formation. Structure growth is delayed in WDM, as a result WDM haloes have a stellar population on average two Gyrs younger than their CDM counterparts. Nevertheless, despite this delayed star formation, CDM and WDM galaxies are both able to reproduce the observed scaling relations for velocity dispersion, stellar mass, size, and metallicity at $z=0$. WDM satellite haloes in a Milky Way mass host are more susceptible to tidal stripping due to their lower concentrations, but their galaxies can even survive longer than the CDM counterparts if they live in a dark matter halo with a steeper central slope. In agreement with our previous CDM satellite study we observe a steepening of the WDM satellites' central dark matter density slope due to stripping. The difference in the average stellar age for satellite galaxies, between CDM and WDM, could be used in the future for disentangling these two models.Comment: 10 pages, 11 figures, accepted for publication on MNRA

Magnetically-controlled velocity selection in a cold atom sample using stimulated Raman transitions

We observe velocity-selective two-photon resonances in a cold atom cloud in the presence of a magnetic field. We use these resonances to demonstrate a simple magnetometer with sub-mG resolution. The technique is particularly useful for zeroing the magnetic field and does not require any additional laser frequencies than are already used for standard magneto-optical traps. We verify the effects using Faraday rotation spectroscopy.Comment: 5 pages, 6 figure