990 research outputs found
The Stability of Isotropic or Orthotopic Cylinders or Flat or Curved Panels, Between and Across Stiffeners, with Any Edge Conditions Between Hinged and Fixed, Under Any Combination of Compression and Shear
Stability of Thin-Walled Tubes Under Torsion
In this report a theoretical solution is developed for the torsion on a round thin-walled tube for which the walls become unstable. The results of this theory are given by a few simple formulas and curves which cover all cases. The differential equations of equilibrium are derived in a simpler form than previously found, it being shown that many items can be neglected
HP3 THE ROLE OF GENERAL PRACTITIONERS IN THE INITIAL MANAGEMENT OF WOMEN WITH URINARY INCONTINENCE IN FRANCE, GERMANY, SPAIN AND THE UK
Persistence of a pinch in a pipe
The response of low-dimensional solid objects combines geometry and physics
in unusual ways, exemplified in structures of great utility such as a
thin-walled tube that is ubiquitous in nature and technology. Here we provide a
particularly surprising consequence of this confluence of geometry and physics
in tubular structures: the anomalously large persistence of a localized pinch
in an elastic pipe whose effect decays very slowly as an oscillatory
exponential with a persistence length that diverges as the thickness of the
tube vanishes, which we confirm experimentally. The result is more a
consequence of geometry than material properties, and is thus equally
applicable to carbon nanotubes as it is to oil pipelines.Comment: 6 pages, 3 figure
Assisting paretic ankle motion with a soft exosuit can reduce whole-body compensatory gait patterns and improve walking efficiency for patients after stroke
Rural-urban population change and migration in Missouri, 1940-1950
Cover title.Includes bibliographical references
Bacterial Adaptation through Loss of Function
The metabolic capabilities and regulatory networks of bacteria have been optimized by evolution in response to selective pressures present in each species' native ecological niche. In a new environment, however, the same bacteria may grow poorly due to regulatory constraints or biochemical deficiencies. Adaptation to such conditions can proceed through the acquisition of new cellular functionality due to gain of function mutations or via modulation of cellular networks. Using selection experiments on transposon-mutagenized libraries of bacteria, we illustrate that even under conditions of extreme nutrient limitation, substantial adaptation can be achieved solely through loss of function mutations, which rewire the metabolism of the cell without gain of enzymatic or sensory function. A systematic analysis of similar experiments under more than 100 conditions reveals that adaptive loss of function mutations exist for many environmental challenges. Drawing on a wealth of examples from published articles, we detail the range of mechanisms through which loss-of-function mutations can generate such beneficial regulatory changes, without the need for rare, specific mutations to fine-tune enzymatic activities or network connections. The high rate at which loss-of-function mutations occur suggests that null mutations play an underappreciated role in the early stages of adaption of bacterial populations to new environments
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