CHERNOBYL EXCLUSION ZONE - A WORLD FAMOUS TOURIST BRAND OF UKRAINE

Annotation. The article identifies the main principles of of functioning and development of the tourism in the Chornobyl radiation and ecological biosphere reserveaffected by the technogenic disaster. The paper provides a rationale fortourismdevelopmentto the Chernobyl exclusion zone as anew direction of the international tourism service market.It defines the main principles of planning and development of thebrand of “Chornobyl radiation and ecological biosphere reserve” (Chernobyl exclusion zone) and providesproposals for itspromotion astheworld-famous tourist brand of Ukraineon the international tourism service market through popularisation of the safe tours to Chernobyl exclusion zone.This article examines the important role of the state in the optimization and arrangementof the market participants activity in this region and tourist offers.The study has confirmedthe safety of the proposed tours with the assistance of specialists of the State Agency of Ukraine on the Exclusion Zone Management, the Chornobyl radiation and ecological biosphere reserve, and State specialised enterprise "Ecocentre". This paper proposes a number ofpractical measures in the context of the formation of the renewed Strategy of the Chernobyl exclusion zone development for optimization of the international tourism service marketthat will ensure the highest level of the travel market consumer's interest in purchasing tours to this region of Ukraine.Annotation. The article identifies the main principles of of functioning and development of the tourism in the Chornobyl radiation and ecological biosphere reserveaffected by the technogenic disaster. The paper provides a rationale fortourismdevelopmentto the Chernobyl exclusion zone as anew direction of the international tourism service market.It defines the main principles of planning and development of thebrand of “Chornobyl radiation and ecological biosphere reserve” (Chernobyl exclusion zone) and providesproposals for itspromotion astheworld-famous tourist brand of Ukraineon the international tourism service market through popularisation of the safe tours to Chernobyl exclusion zone.This article examines the important role of the state in the optimization and arrangementof the market participants activity in this region and tourist offers.The study has confirmedthe safety of the proposed tours with the assistance of specialists of the State Agency of Ukraine on the Exclusion Zone Management, the Chornobyl radiation and ecological biosphere reserve, and State specialised enterprise "Ecocentre". This paper proposes a number ofpractical measures in the context of the formation of the renewed Strategy of the Chernobyl exclusion zone development for optimization of the international tourism service marketthat will ensure the highest level of the travel market consumer's interest in purchasing tours to this region of Ukraine

Correlation investigation of the brightness of GDE-grams using the methods of computer graphics and direct measurements

There are two methods of measuring the glow of a liquid under the conditions of gas-discharge imaging. This is a investigation of the brightness of GD-grams - a digital image of streamers created under these conditions, and a direct measurement of brightness using a luminometer, which is carried out during the formation of a streamer during a gas discharge. In the first case, the digital image is analyzed using computer graphics methods and certain software. In the second, the results of direct measurement are analyzed. We have analyzed these two methods using the example of the glow of water under the conditions of gas-discharge visualization. It is shown that with direct measurements the brightness values ​​are higher than when investigating the brightness of a digital image of the same streamer obtained in the same time period. Namely 1.5 cd/m2 and 1.7 cd/m2. The difference is 13% and significantly exceeds the measurement error of the brightness meter (± 7%). According to the results of our research, we suggest that, at the very least, when calibrating the devices that create the GDV-grams, use direct measurements of the glow of the liquid in photometric units. For example, in brightness units

Совершенствование методов определения частотно-инерционных и кинематических свойств систем с распределенными параметрами путем анализа их собственных колебаний

Досліджено коливання (вільні) тонкого диску. Визначено співвідношення для товстих дисків, які враховують інерцію обертання та зсув. Побудовано залежності резонансної частоти коливань диску з вузловими колами.Free vibrations of the thin disc are studied. The equation for thick discs which include the inertia of rotation and the slide is determined. The dependencies of the resonant frequency of oscillation with knotty circles are made.Исследованы колебания (свободные) тонкого диска. Определены соотношения для толстых дисков, которые учитывают инерцию вращения и смещение. Построены зависимости резонансной частоты колебаний диска с узловыми кругами

ОСНОВНІ ВИМОГИ ДО СТРУКТУРИ ТИПОВИХ МЕДИЧНИХ ІНФОРМАЦІЙНИХ СИСТЕМ В УПРАВЛІННІ ОХОРОНОЮ ЗДОРОВ'Я

In modern development of health care for providing proper quality of medicare there is a necessity in accumulation and analysis of data during the long period, application of electronic and consulting models. The presented work determines basic principles of construction of the informative systems for optimization of management of health care establishments, first of all, at making decisions. Basic tasks and requirements to the informative systems on regional and local levels are considered. It is proven that typical structures of the medical informative systems must have possibilities of risks monitoring for patients and decisions as to danger identification for managers.В сучасних умовах розвитку охорони здоров’я для забезпечення належної якості медичної допомоги існує потреба в накопиченні й аналізі даних впродовж тривалого періоду, застосуванні електронних експертних систем. Представлена робота визначає основні принципи побудови інформаційних систем для оптимізації управління закладами охорони здоров’я, насамперед, при прийнятті рішень. Розглянуті основні завдання та вимоги до інформаційних систем на регіональному і локальному рівнях. Доведено, що типові структури медичних інформаційних систем повинні мати можливості моніторингу ризиків для пацієнтів і рішення щодо ідентифікації небезпеки для  управлінців

ДОСВІД ВИЗНАЧЕННЯ ІНТРАТЕКАЛЬНОГО СИНТЕЗУ АНТИТІЛ У ПАЦІЄНТІВ З УРАЖЕННЯМИ ЦЕНТРАЛЬНОЇ НЕРВОВОЇ СИСТЕМИ

The aim of the work – to study the frequency of intrathecal synthesis of specific antibodies at patients with inflammatory lesions of the central nervous system.Patients and methods. In this work the data of the determination of intrathecal synthesis of specific antibodies (ITSA) in 90 patients are given who were treated at the Lev Hromashevskyi Institute of Epidemiology and Infectious Diseases. The research included quantitative definition of antibodies of the class IgG in serum (S) and cerebrospinal fluid (CSF) to neurotropic pathogens: herpes simplex virus 1/2, cytomegalovirus, Epstein-Barr virus, varicella zoster virus, rubella virus, Borrelies. Calculations of ITSA indicators were carried out according to the method of Reiber H. The condition of a hematoencephalic barrier (HEB) was estimated by means of coefficient of albumine (Qalb) taking into account age norms.Results. ITSA was established in (25.6±4.6) % of the examined patients with damages of the central nervous system. In patients with ITSA most often (in 52.2 %) simultaneously present antibodies to several neurotropic pathogens. Detection of ITSA at the examined patients didn’t depend on concentration of specific antibodies in S and CSF and wasn’t followed by malfunction of HEB. The incidence of HEB dysfunction at patients with ITSA and without ITSA appeared with an identical frequency (13,0 % and 13,6 % respectively).Мета роботи. Вивчити частоту інтратекального синтезу специфічних антитіл у пацієнтів зі запальними ураженнями центральної нервової системи.Пацієнти і методи. В роботі наведені дані визначення інтратекального синтезу специфічних антитіл (ІТСА) у 90 пацієнтів, які проходили лікування в клініці ДУ «Інститут епідеміології та інфекційних хвороб ім. Л.В. Громашевського». Дослідження включало кількісне визначення антитіл класу Ig G в сироватці крові (СК) та спинномозковій рідині (СМР) до нейротропних збудників: вірусу простого герпесу 1/2 типу, цитомегаловірусу, вірусу Епштейна-Барр, вірусу оперізувального лишаю, вірусу кору, вірусу краснухи, бореліям. Розрахунки показників ІТСА проведені за методикою Reiber H. Стан гематоенцефалічного бар’єру (ГЕБ) оцінювали за допомогою коефіцієнту альбуміну (Qalb) з урахуванням вікових норм.Результати. ІТСА встановлений у (25,6±4,6) % обстежених пацієнтів з ураженнями ЦНС. У пацієнтів з ІТСА найчастіше (у 52,2 %) одночасно були присутні антитіла до декількох нейротропних збудників. Виявлення ІТСА в обстежених пацієнтів не залежало від концентрації специфічних антитіл у СК і СМР і не супроводжувалося порушенням функції ГЕБ. Випадки дисфункції ГЕБ у пацієнтів з ІТСА та без ІТСА виявлялися з однаковою частотою (13,0 та 13,6 % відповідно)

First results from the JWST Early Release Science Program Q3D: Benchmark Comparison of Optical and Mid-IR Tracers of a Dusty, Ionized Red Quasar Wind at z=0.435

The [OIII] 5007 A emission line is the most common tracer of warm, ionized outflows in active galactic nuclei across cosmic time. JWST newly allows us to use mid-infrared spectral features at both high spatial and spectral resolution to probe these same winds. Here we present a comparison of ground-based, seeing-limited [OIII] and space-based, diffraction-limited [SIV] 10.51 micron maps of the powerful, kpc-scale outflow in the Type 1 red quasar SDSS J110648.32+480712.3. The JWST data are from the Mid-InfraRed Instrument (MIRI). There is a close match in resolution between the datasets (0."4--0."6), in ionization potential of the O+2 and S+3 ions (35 eV), and in line sensitivity (1e-17 to 2e-17 erg/s/cm2/arcsec2). The [OIII] and [SIV] line shapes match in velocity and linewidth over much of the 20 kpc outflowing nebula, and [SIV] is the brightest line in the rest-frame 3.5--19.5 micron range, demonstrating its usefulness as a mid-IR probe of quasar outflows. [OIII] is nevertheless intriniscally brighter and provides better contrast with the point-source continuum, which is strong in the mid-IR. There is a strong anticorrelation of [OIII]/[SIV] with average velocity, which is consistent with a scenario of differential obscuration between the approaching (blueshifted) and receding (redshifted) sides of the flow. The dust in the wind may also obscure the central quasar, consistent with models that attribute red quasar extinction to dusty winds.Comment: Submitted to ApJ

First results from the JWST Early Release Science Program Q3D: Ionization cone, clumpy star formation and shocks in a z=3z=3 extremely red quasar host

Massive galaxies formed most actively at redshifts $z=1-3$ during the period known as `cosmic noon.' Here we present an emission-line study of an extremely red quasar SDSSJ165202.64+172852.3 host galaxy at $z=2.94$, based on observations with the Near Infrared Spectrograph (NIRSpec) integral field unit (IFU) on board JWST. We use standard emission-line diagnostic ratios to map the sources of gas ionization across the host and a swarm of companion galaxies. The quasar dominates the photoionization, but we also discover shock-excited regions orthogonal to the ionization cone and the quasar-driven outflow. These shocks could be merger-induced or -- more likely, given the presence of a powerful galactic-scale quasar outflow -- these are signatures of wide-angle outflows that can reach parts of the galaxy that are not directly illuminated by the quasar. Finally, the kinematically narrow emission associated with the host galaxy presents as a collection of 1 kpc-scale clumps forming stars at a rate of at least 200 $M_{\odot}$ yr$^{-1}$. The ISM within these clumps shows high electron densities, reaching up to 3,000 cm$^{-3}$ with metallicities ranging from half to a third solar with a positive metallicity gradient and V band extinctions up to 3 magnitudes. The star formation conditions are far more extreme in these regions than in local star-forming galaxies but consistent with that of massive galaxies at cosmic noon. JWST observations reveal an archetypical rapidly forming massive galaxy undergoing a merger, a clumpy starburst, an episode of obscured near-Eddington quasar activity, and an extremely powerful quasar outflow simultaneously.Comment: 19 pages, 8 figures. Accepted for publication in Ap

First results from the JWST Early Release Science Program Q3D: The Warm Ionized Gas Outflow in z ~ 1.6 Quasar XID 2028 and its Impact on the Host Galaxy

Quasar feedback may regulate the growth of supermassive black holes, quench coeval star formation, and impact galaxy morphology and the circumgalactic medium. However, direct evidence for quasar feedback in action at the epoch of peak black hole accretion at z ~ 2 remains elusive. A good case in point is the z = 1.6 quasar WISEA J100211.29+013706.7 (XID 2028) where past analyses of the same ground-based data have come to different conclusions. Here we revisit this object with the integral field unit of the Near Infrared Spectrograph (NIRSpec) on board the James Webb Space Telescope (JWST) as part of Early Release Science program Q3D. The excellent angular resolution and sensitivity of the JWST data reveal new morphological and kinematic sub-structures in the outflowing gas plume. An analysis of the emission line ratios indicates that photoionization by the central quasar dominates the ionization state of the gas with no obvious sign for a major contribution from hot young stars anywhere in the host galaxy. Rest-frame near-ultraviolet emission aligned along the wide-angle cone of outflowing gas is interpreted as a scattering cone. The outflow has cleared a channel in the dusty host galaxy through which some of the quasar ionizing radiation is able to escape and heat the surrounding interstellar and circumgalactic media. The warm ionized outflow is not powerful enough to impact the host galaxy via mechanical feedback, but radiative feedback by the AGN, aided by the outflow, may help explain the unusually small molecular gas mass fraction in the galaxy host.Comment: 17 pages, 9 figures, accepted for publication in The Astrophysical Journa

Airborne Signals from a Wounded Leaf Facilitate Viral Spreading and Induce Antibacterial Resistance in Neighboring Plants

Many plants release airborne volatile compounds in response to wounding due to pathogenic assault. These compounds serve as plant defenses and are involved in plant signaling. Here, we study the effects of pectin methylesterase (PME)-generated methanol release from wounded plants (“emitters”) on the defensive reactions of neighboring “receiver” plants. Plant leaf wounding resulted in the synthesis of PME and a spike in methanol released into the air. Gaseous methanol or vapors from wounded PME-transgenic plants induced resistance to the bacterial pathogen Ralstonia solanacearum in the leaves of non-wounded neighboring “receiver” plants. In experiments with different volatile organic compounds, gaseous methanol was the only airborne factor that could induce antibacterial resistance in neighboring plants. In an effort to understand the mechanisms by which methanol stimulates the antibacterial resistance of “receiver” plants, we constructed forward and reverse suppression subtractive hybridization cDNA libraries from Nicotiana benthamiana plants exposed to methanol. We identified multiple methanol-inducible genes (MIGs), most of which are involved in defense or cell-to-cell trafficking. We then isolated the most affected genes for further analysis: β-1,3-glucanase (BG), a previously unidentified gene (MIG-21), and non-cell-autonomous pathway protein (NCAPP). Experiments with Tobacco mosaic virus (TMV) and a vector encoding two tandem copies of green fluorescent protein as a tracer of cell-to-cell movement showed the increased gating capacity of plasmodesmata in the presence of BG, MIG-21, and NCAPP. The increased gating capacity is accompanied by enhanced TMV reproduction in the “receivers”. Overall, our data indicate that methanol emitted by a wounded plant acts as a signal that enhances antibacterial resistance and facilitates viral spread in neighboring plants

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised