The roles of HOXD10 in the development and progression of head and neck squamous cell carcinoma (HNSCC).

Background: HOX gene expression is altered in many cancers; previous microarray revealed changes in HOX gene expression in head and neck squamous cell carcinoma (HNSCC), particularly HOXD10. Methods: HOXD10 expression was assessed by qPCR and immunoblotting in vitro and by immunohistochemistry (IHC) in tissues. Low-expressing cells were stably transfected with HOXD10 and the phenotype assessed with MTS, migration and adhesion assays and compared with the effects of siRNA knockdown in high-HOXD10-expressing cells. Novel HOXD10 targets were identified using expression microarrays, confirmed by reporter assay, and validated in tissues using IHC. Results: HOXD10 expression was low in NOKs, high in most primary tumour cells, and low in lymph node metastasis cells, a pattern confirmed using IHC in tissues. Overexpression of HOXD10 decreased cell invasion but increased proliferation, adhesion and migration, with knockdown causing reciprocal effects. There was no consistent effect on apoptosis. Microarray analysis identified several putative HOXD10-responsive genes, including angiomotin (AMOT-p80) and miR-146a. These were confirmed as HOXD10 targets by reporter assay. Manipulation of AMOT-p80 expression resulted in phenotypic changes similar to those on manipulation of HOXD10 expression. Conclusions: HOXD10 expression varies by stage of disease and produces differential effects: high expression giving cancer cells a proliferative and migratory advantage, and low expression may support invasion/metastasis, in part, by modulating AMOT-p80 levels

Анализ структурных изменений внутреннего потребления ТЭР г. Москвы

Purpose of the study. The fuel and energy complex is one of the important components of the mechanism of functioning of the national economy in general and municipal economy in particular, since the main tasks of the complex include: provision of hot water supply all year round and heat during the winter period, meeting the needs of the population and municipal economy in gas, supply of gasoline and diesel fuel to satisfy consumers, as well as the supply of coal, peat, fuel oil and other fuels for the urban economy. An important role is played by enterprises of the fuel and energy complex in terms of providing jobs to the population. The fuel and energy complex of Moscow is one of the largest in Russia. A feature of its functioning is the concentrated consumption of gas, fuel, electricity, heat energy and other energy resources. The formation and development of the fuel and energy complex in Moscow is largely due to the rapidly developing economy of the megapolis – large-scale construction of housing and infrastructure, sustainable population growth entails a constant increase in consumption of fuel and energy resources. Monitoring the efficiency of the use of fuel and energy resources makes it possible to identify ways to reduce the volume of consumption to a level that allows, within the approved limit, to implement the planned rate of social and economic development of the city. Materials and methods. Information base of the research was made by statistical data characterizing the volume of consumption of certain types of fuel and energy resources in the market of the Moscow region. The methodological basis of the study is made up of statistical methods of analysis of structure and structural shifts, dynamics. Their use made it possible to conduct a thorough analysis of the differentiation of consumption of various types of fuel and energy resources, as well as structural changes in the differentiations in question. It made it possible to identify existing trends in the development of the fuel and energy complex in the capital region Results. The analysis allowed to identify the current trends in consumption of the main types of fuel and energy resources in Moscow, to assess the structure and structural changes in consumption of fuel and energy resources in Moscow, in order to assess the energy efficiency of the fuel and energy complex of the capital. Conclusion. The main goal of Moscow’s energy policy is to create an economically efficient, dynamically developing and financially sustainable fuel and energy complex equipped with advanced technologies and highly qualified personnel and meeting the requirements of the time and status of Moscow. Increasing the efficiency of the use of fuel and energy resources, for Moscow as one of the coldest capitals of the world, is becoming one of the priority tasks. Consequently, another task of developing the fuel and energy complex of the city is to expand the scale of the introduction of secondary energy resources and bring the indicator of their use to 50%. That is why, a comprehensive analysis of the dynamics and structure of consumption of fuel and energy resources will allow not only to assess the existing patterns of distribution and trends, but also as a consequence to form a highly effective energy strategy for the megacity. Цель исследования. Топливно-энергетический комплекс является одним из важных составляющих механизма функционирования национальной экономики в целом и городского хозяйства в частности, поскольку к основным решаемым задачам комплекса можно отнести: обеспечение горячего водоснабжения круглый год и теплом в зимний период, удовлетворение потребностей населения и городского хозяйства в газе, поставка бензина и дизельного топлива для удовлетворения потребителей, а так- же поставка угля, торфа, мазута и прочих видов топлива для городского хозяйства. Немаловажную роль играют предприятия топливно-энергетического комплекса с точки зрения обеспечения рабочими местами населения. Топливно-энергетический комплекс Москвы – один из крупнейших в России. Особенностью его функционирования является концентрированное потребление газа, топлива, электроэнергии, тепловой энергии и прочих энергетических ресурсов. Формирование и развитие топливно-энергетического комплекса Москвы во многом обусловлено стремительно развивающейся экономикой мегаполиса – масштабное строительство жилья и инфраструктуры, устойчивый прирост численности населения влечет постоянный рост потребления топливно-энергетических ресурсов. Мониторинг эффективности использования топливно-энергетических ресурсов дает возможность выявить пути снижения объема потребления до уровня, позволяющего в рамках утвержденного лимита, реализовать запланированный темп социально-экономического развития города. Материалы и методы. Информационную базу исследования составили статистические данные характеризующие объем потребления отдельных видов топливно-энергетических ресурсов на рынке московского региона. Методологическую основу исследования составляют статистические методы анализа структуры и структурных сдвигов, динамики. Их использование позволило провести глубокий анализ дифференциации потребления различных видов топливно-энергетических ресурсов, а также структурных изменений в рассматриваемых дифференциациях. Дало возможность выявить существующие тенденции в развитии топливно-энергетического комплекса столичного региона Результаты. Проведенный анализ позволил выявить сложившиеся тенденции объемов потребления основных видов топливно-энергетических ресурсов г. Москвы, оценить структуру и структурные изменения потребления топливно-энергетических ресурсов в г. Москва, с целью оценки энергоэффективности топливно-энергетического комплекса столицы. Заключение. Главная цель энергетической политики Москвы состоит в формировании экономически эффективного, динамично развивающегося и финансово устойчивого топливно-энергетического комплекса, оснащенного передовыми технологиями и высококвалифицированными кадрами и соответствующего требованиям времени и статусу Москвы. Повышение эффективности использования топливно-энергетических ресурсов, для Москвы как для одной из самых холодных столиц мира, становится одной из приоритетных задач. В следствии этого, еще одной задачей развития топливно-энергетического комплекса города выступает расширение масштабов внедрения вторичных энергетических ресурсов и доведение показателя их использования до 50%. Именно поэтому, всесторонний анализ динамики и структуры потребления топливно-энергетических ресурсов позволит не только оценить существующие закономерности распределения и тенденции, но и как следствие сформировать высоко эффективную энергетическую стратегию мегаполиса.

The role of icIL-1RA in keratinocyte senescence and development of the senescence-associated secretory phenotype

There is compelling evidence that senescent cells, through the senescence-associated secretory phenotype (SASP), can promote malignant transformation and invasion. Interleukin-1 (IL-1) is a key mediator of this cytokine network, but the control of its activity in the senescence programme has not been elucidated. IL-1 signalling is regulated by IL-1RA, which has four variants. Here, we show that expression of intracellular IL-1RA type 1 (icIL-1RA1), which competitively inhibits binding of IL-1 to its receptor, is progressively lost during oral carcinogenesis ex vivo and that the pattern of expression is associated with keratinocyte replicative fate in vitro. We demonstrate that icIL-1RA1 is an important regulator of the SASP in mortal cells, as CRISPR/Cas9-mediated icIL-1RA1 knockdown in normal and mortal dysplastic oral keratinocytes is followed by increased IL-6 and IL-8 secretion, and rapid senescence following release from RhoA-activated kinase inhibition. Thus, we suggest that downregulation of icIL-1RA1 in early stages of the carcinogenesis process can enable the development of a premature and deregulated SASP, creating a pro-inflammatory state in which cancer is more likely to arise.A scholarship from Becas Chile, Comisión Nacional de Investigación Cientı́fica y Tecnológicahttps://journals.biologists.com/jcsam2022Oral Pathology and Oral Biolog

Data from an International Multi-Centre Study of Statistics and Mathematics Anxieties and Related Variables in University Students (the SMARVUS Dataset)

This large, international dataset contains survey responses from N = 12,570 students from 100 universities in 35 countries, collected in 21 languages. We measured anxieties (statistics, mathematics, test, trait, social interaction, performance, creativity, intolerance of uncertainty, and fear of negative evaluation), self-efficacy, persistence, and the cognitive reflection test, and collected demographics, previous mathematics grades, self-reported and official statistics grades, and statistics module details. Data reuse potential is broad, including testing links between anxieties and statistics/mathematics education factors, and examining instruments’ psychometric properties across different languages and contexts. Data and metadata are stored on the Open Science Framework website [https://osf.io/mhg94/]

Data from an International Multi-Centre Study of Statistics and Mathematics Anxieties and Related Variables in University Students (the SMARVUS Dataset)

This large, international dataset contains survey responses from N = 12,570 students from 100 universities in 35 countries, collected in 21 languages. We measured anxieties (statistics, mathematics, test, trait, social interaction, performance, creativity, intolerance of uncertainty, and fear of negative evaluation), self-efficacy, persistence, and the cognitive reflection test, and collected demographics, previous mathematics grades, self-reported and official statistics grades, and statistics module details. Data reuse potential is broad, including testing links between anxieties and statistics/mathematics education factors, and examining instruments’ psychometric properties across different languages and contexts. Data and metadata are stored on the Open Science Framework website (https://osf.io/mhg94/).</p&gt

Data from an International Multi-Centre Study of Statistics and Mathematics Anxieties and Related Variables in University Students (the SMARVUS Dataset)

This large, international dataset contains survey responses from N = 12,570 students from 100 universities in 35 countries, collected in 21 languages. We measured anxieties (statistics, mathematics, test, trait, social interaction, performance, creativity, intolerance of uncertainty, and fear of negative evaluation), self-efficacy, persistence, and the cognitive reflection test, and collected demographics, previous mathematics grades, self-reported and official statistics grades, and statistics module details. Data reuse potential is broad, including testing links between anxieties and statistics/mathematics education factors, and examining instruments’ psychometric properties across different languages and contexts

Undang-undang ketenagakerjaan dan aplikasinya/ Rukiyah

vi, 286 hal.; 23 cm

Analysis of the structural changes in domestic consumption of FUEL and energetic resources of Moscow

Purpose of the study. The fuel and energy complex is one of the important components of the mechanism of functioning of the national economy in general and municipal economy in particular, since the main tasks of the complex include: provision of hot water supply all year round and heat during the winter period, meeting the needs of the population and municipal economy in gas, supply of gasoline and diesel fuel to satisfy consumers, as well as the supply of coal, peat, fuel oil and other fuels for the urban economy. An important role is played by enterprises of the fuel and energy complex in terms of providing jobs to the population. The fuel and energy complex of Moscow is one of the largest in Russia. A feature of its functioning is the concentrated consumption of gas, fuel, electricity, heat energy and other energy resources. The formation and development of the fuel and energy complex in Moscow is largely due to the rapidly developing economy of the megapolis – large-scale construction of housing and infrastructure, sustainable population growth entails a constant increase in consumption of fuel and energy resources. Monitoring the efficiency of the use of fuel and energy resources makes it possible to identify ways to reduce the volume of consumption to a level that allows, within the approved limit, to implement the planned rate of social and economic development of the city. Materials and methods. Information base of the research was made by statistical data characterizing the volume of consumption of certain types of fuel and energy resources in the market of the Moscow region. The methodological basis of the study is made up of statistical methods of analysis of structure and structural shifts, dynamics. Their use made it possible to conduct a thorough analysis of the differentiation of consumption of various types of fuel and energy resources, as well as structural changes in the differentiations in question. It made it possible to identify existing trends in the development of the fuel and energy complex in the capital region Results. The analysis allowed to identify the current trends in consumption of the main types of fuel and energy resources in Moscow, to assess the structure and structural changes in consumption of fuel and energy resources in Moscow, in order to assess the energy efficiency of the fuel and energy complex of the capital. Conclusion. The main goal of Moscow’s energy policy is to create an economically efficient, dynamically developing and financially sustainable fuel and energy complex equipped with advanced technologies and highly qualified personnel and meeting the requirements of the time and status of Moscow. Increasing the efficiency of the use of fuel and energy resources, for Moscow as one of the coldest capitals of the world, is becoming one of the priority tasks. Consequently, another task of developing the fuel and energy complex of the city is to expand the scale of the introduction of secondary energy resources and bring the indicator of their use to 50%. That is why, a comprehensive analysis of the dynamics and structure of consumption of fuel and energy resources will allow not only to assess the existing patterns of distribution and trends, but also as a consequence to form a highly effective energy strategy for the megacity

Simulation and animation of Panama Canal operations

This paper involves Simulation and Animation of the greatest sea-to sea lock canal of ail time, and the epitome of engineering ingenuity and perseverance: Panama Canal. The emphasis is on application of simulation far transportation based operational problems. The project involves simulation of Panama Canal operations and then animating the results obtained from simulation. A GUI based software is developed. Coding far the simulation program is done in VC++, while coding far animation program is done in Java. The Java program takes output of simulation program as its input and produces animation. The software is user friendly and helps the user in understanding the results obtained in simulation by animating them

Undang-undang ketenagakerjaan dan aplikasinya/ Rukiyah

vi, 286 hal.; 23 c