Ionic behavior assessment of surface-active compounds from corn steep liquor by exchange resins

Depending on their ionic nature, biosurfactants can be classified as nonionic, anionic, cationic, or amphoteric. The ionic behavior of biosurfactants is an important characteristic that dictates their use in industrial applications. In this work, a biosurfactant extract obtained from corn steep liquor was subjected to anionic or cationic resins, in order to study the ionic behavior under different operational conditions using response surface methodology. The independent variables included in the study are the dilution of biosurfactant solution, the amount of cationic or anionic resin, and the extraction time, whereas the dependent variables studied consisted of the surface tension of biosurfactant aqueous solution, after contacting with anionic or cationic resin. The results showed that biosurfactant extracted from corn steep liquor is amphoteric, since both resins were able to entrap this biosurfactant, making it particularly suited for use in personal care preparations for sensitive skin.Peer ReviewedPostprint (author's final draft

Analytical results for a Bessel function times Legendre polynomials class integrals

When treating problems of vector diffraction in electromagnetic theory, the evaluation of the integral involving Bessel and associated Legendre functions is necessary. Here we present the analytical result for this integral that will make unnecessary numerical quadrature techniques or localized approximations. The solution is presented using the properties of the Bessel and associated Legendre functions.Comment: 4 page

Dissecting bombs and bursts: non-LTE inversions of low-atmosphere reconnection in SST and IRIS observations

Ellerman bombs and UV bursts are transient brightenings that are ubiquitously observed in the lower atmospheres of active and emerging flux regions. Here we present inversion results of SST/CRISP and CHROMIS, as well as IRIS data of such transient events. Combining information from the Mg II h & k, Si IV and Ca II 8542A and Ca II H & K lines, we aim to characterise their temperature and velocity stratification, as well as their magnetic field configuration. We find average temperature enhancements of a few thousand kelvin close to the classical temperature minimum, but localised peak temperatures of up to 10,000-15,000 K from Ca II inversions. Including Mg II generally dampens these temperature enhancements to below 8000 K, while Si IV requires temperatures in excess of 10,000 K at low heights, but may also be reproduced with secondary temperature enhancements of 35,000-60,000 K higher up. However, reproducing Si IV comes at the expense of overestimating the Mg II emission. The line-of-sight velocity maps show clear bi-directional jet signatures and strong correlation with substructure in the intensity images, with slightly larger velocities towards the observer than away. The magnetic field parameters show an enhancement of the horizontal field co-located with the brightenings at similar heights as the temperature increase. We are thus able to largely reproduce the observational properties of Ellerman bombs with UV burst signature with temperature stratifications peaking close to the classical temperature minimum. Correctly modelling the Si IV emission in agreement with all other diagnostics is, however, an outstanding issue. Accounting for resolution differences, fitting localised temperature enhancements and/or performing spatially-coupled inversions is likely necessary to obtain better agreement between all considered diagnostics.Comment: Accepted for publication in Astronomy & Astrophysics. 24 pages, 17 figure

Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43

Glioblastoma Multiforme (GBM) is an aggressive adult primary brain tumor with poor prognosis. GBM patients develop resistance to the frontline chemotherapy, temozolomide (TMZ). As the connexins (Cx) have been shown to have a complex role in GBM, we investigated the role of Cx43 in TMZ resistance. Cx43 was increased in the TMZ-resistant low passage and cell lines. This correlated with the data in The Cancer Genome Atlas. Cx43 knockdown, reporter gene assays, chromatin immunoprecipitation assay, real-time PCR and western blots verified a role for Cx43 in TMZ resistance. This occurred by TMZ-resistant GBM cells being able to activate epidermal growth factor receptor (EGFR). In turn, EGFR activated the JNK-ERK1/2-AP-1 axis to induce Cx43. The increased Cx43 was functional as indicated by gap junctional intercellular communication among the resistant GBM cells. Cell therapy could be a potential method to deliver drugs, such as anti-EGF to tumor cells. Similar strategies could be used to reverse the expression of Cx43 to sensitize GBM cells to TMZ. The studies showed the potential for targeting EGF in immune therapy. These agents can be used in conjunction with stem cell therapy to treat GBM